Detailed information for compound 2146650

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 372.16 | Formula: C19H21FN4O3
  • H donors: 3 H acceptors: 3 LogP: 3.04 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 0
  • SMILES: CNCCOc1cc2ncnc(c2cc1OC)Nc1c(F)ccc(c1C)O
  • InChi: InChI=1S/C19H21FN4O3/c1-11-15(25)5-4-13(20)18(11)24-19-12-8-16(26-3)17(27-7-6-21-2)9-14(12)22-10-23-19/h4-5,8-10,21,25H,6-7H2,1-3H3,(H,22,23,24)
  • InChiKey: LXINGPYRHFOCIB-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ret proto-oncogene References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Onchocerca volvulus 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Entamoeba histolytica protein kinase, putative 0.0002 0.5 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0002 0.5 0.5
Giardia lamblia Kinase, NEK 0.0002 0.5 0.5
Plasmodium vivax tyrosine kinase-like protein, putative 0.0002 0.5 0.5
Trypanosoma brucei Flagellum attachment zone protein 20 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Echinococcus granulosus activin receptor type 0.0002 0.5 0.5
Brugia malayi SRC-1 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0002 0.5 0.5
Entamoeba histolytica protein kinase, putative 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Plasmodium falciparum protein kinase, putative 0.0002 0.5 0.5
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0002 0.5 0.5
Loa Loa (eye worm) TK protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0002 0.5 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Entamoeba histolytica hypothetical protein 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Entamoeba histolytica hypothetical protein 0.0002 0.5 0.5
Echinococcus granulosus ephrin type A receptor 4 A 0.0002 0.5 0.5
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0002 0.5 0.5
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0002 0.5 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0002 0.5 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.0002 0.5 0.5
Brugia malayi integrin-linked kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.5 0.5
Loa Loa (eye worm) TK protein kinase 0.0002 0.5 0.5
Loa Loa (eye worm) TK protein kinase 0.0002 0.5 0.5
Echinococcus multilocularis activated cdc42 kinase 1 0.0002 0.5 0.5
Brugia malayi bone morphogenetic protein type 1 receptor 0.0002 0.5 0.5
Entamoeba histolytica protein kinase, putative 0.0002 0.5 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0002 0.5 0.5
Entamoeba histolytica hypothetical protein 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.0002 0.5 0.5
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0002 0.5 0.5
Schistosoma mansoni hypothetical protein 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Echinococcus granulosus fibroblast growth factor receptor 4 0.0002 0.5 0.5
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0002 0.5 0.5
Loa Loa (eye worm) RGC/RGC protein kinase 0.0002 0.5 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0002 0.5 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0002 0.5 0.5
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0002 0.5 0.5
Echinococcus granulosus integrin linked protein kinase 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0002 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0002 0.5 0.5
Loa Loa (eye worm) TK protein kinase 0.0002 0.5 0.5
Schistosoma mansoni protein kinase 0.0002 0.5 0.5
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0002 0.5 0.5
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0002 0.5 0.5
Entamoeba histolytica hypothetical protein 0.0002 0.5 0.5
Onchocerca volvulus Tyrosine kinase homolog 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0002 0.5 0.5
Entamoeba histolytica receptor protein kinase, putative 0.0002 0.5 0.5
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0002 0.5 0.5
Schistosoma mansoni protein kinase 0.0002 0.5 0.5
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0002 0.5 0.5
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Giardia lamblia Protein 21.1 0.0002 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0002 0.5 0.5
Entamoeba histolytica serine/threonine kinase, putative 0.0002 0.5 0.5
Onchocerca volvulus 0.0002 0.5 0.5
Entamoeba histolytica protein kinase, putative 0.0002 0.5 0.5
Echinococcus multilocularis raf serine:threonine protein kinase 0.0002 0.5 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0002 0.5 0.5
Entamoeba histolytica protein kinase, putative 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase Abl 0.0002 0.5 0.5
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0002 0.5 0.5
Schistosoma mansoni protein kinase 0.0002 0.5 0.5
Giardia lamblia Kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0002 0.5 0.5
Echinococcus granulosus retinal guanylyl cyclase 2 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0002 0.5 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0002 0.5 0.5
Leishmania major protein kinase, putative 0.0002 0.5 0.5
Entamoeba histolytica serine/threonine kinase, putative 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Onchocerca volvulus 0.0002 0.5 0.5
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0002 0.5 0.5
Echinococcus granulosus tyrosine protein kinase csk 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Loa Loa (eye worm) RGC/RGC protein kinase 0.0002 0.5 0.5
Entamoeba histolytica hypothetical protein 0.0002 0.5 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0002 0.5 0.5
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0002 0.5 0.5
Echinococcus granulosus tyrosine protein kinase shark 0.0002 0.5 0.5
Echinococcus granulosus activated cdc42 kinase 1 0.0002 0.5 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0002 0.5 0.5
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0002 0.5 0.5
Entamoeba histolytica protein kinase, putative 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0002 0.5 0.5
Echinococcus granulosus raf serine:threonine protein kinase 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0002 0.5 0.5
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0002 0.5 0.5
Schistosoma mansoni protein kinase 0.0002 0.5 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0002 0.5 0.5
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0002 0.5 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.5 0.5
Loa Loa (eye worm) TK protein kinase 0.0002 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0002 0.5 0.5
Echinococcus multilocularis FL cytokine receptor 0.0002 0.5 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0002 0.5 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0002 0.5 0.5
Echinococcus granulosus retinal guanylyl cyclase 2 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0002 0.5 0.5
Brugia malayi Furin-like cysteine rich region family protein 0.0002 0.5 0.5
Loa Loa (eye worm) TK/ACK protein kinase 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0002 0.5 0.5
Echinococcus granulosus protein tyrosine kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Schistosoma mansoni protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Loa Loa (eye worm) TK/EPH protein kinase 0.0002 0.5 0.5
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0002 0.5 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Entamoeba histolytica protein kinase, putative 0.0002 0.5 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0002 0.5 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase pr2 0.0002 0.5 0.5
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0002 0.5 0.5
Echinococcus granulosus insulin receptor 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Onchocerca volvulus 0.0002 0.5 0.5
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0002 0.5 0.5
Loa Loa (eye worm) RGC/RGC protein kinase 0.0002 0.5 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0002 0.5 0.5
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Onchocerca volvulus 0.0002 0.5 0.5
Echinococcus granulosus tyrosine protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.5 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0002 0.5 0.5
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0002 0.5 0.5
Echinococcus multilocularis protein tyrosine kinase 0.0002 0.5 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.0002 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0002 0.5 0.5
Loa Loa (eye worm) TK/ALK protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0002 0.5 0.5
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0002 0.5 0.5
Entamoeba histolytica tyrosin kinase, putative 0.0002 0.5 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0002 0.5 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0002 0.5 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0002 0.5 0.5
Trichomonas vaginalis AGC family protein kinase 0.0002 0.5 0.5
Loa Loa (eye worm) TK protein kinase 0.0002 0.5 0.5
Loa Loa (eye worm) TK protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Echinococcus granulosus tyrosine kinase 0.0002 0.5 0.5
Loa Loa (eye worm) TK/ABL protein kinase 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Toxoplasma gondii protein kinase 0.0002 0.5 0.5
Trypanosoma cruzi protein kinase, putative 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.5 0.5
Echinococcus granulosus tyrosine protein kinase csk 0.0002 0.5 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0002 0.5 0.5
Entamoeba histolytica serine/threonine kinase, putative 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Plasmodium vivax protein kinase, putative 0.0002 0.5 0.5
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0002 0.5 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0002 0.5 0.5
Trichomonas vaginalis STE family protein kinase 0.0002 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0002 0.5 0.5
Plasmodium falciparum protein kinase, putative 0.0002 0.5 0.5
Onchocerca volvulus 0.0002 0.5 0.5
Loa Loa (eye worm) TK/CSK protein kinase 0.0002 0.5 0.5
Entamoeba histolytica tyrosin kinase, putative 0.0002 0.5 0.5
Schistosoma mansoni protein kinase 0.0002 0.5 0.5
Loa Loa (eye worm) TK/Met protein kinase 0.0002 0.5 0.5
Schistosoma mansoni ephrin receptor 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Loa Loa (eye worm) TK/DDR protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis TK family protein kinase 0.0002 0.5 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0002 0.5 0.5
Entamoeba histolytica protein kinase, putative 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0002 0.5 0.5
Brugia malayi Receptor family ligand binding region containing protein 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Brugia malayi Tyrosine-protein kinase abl-1 0.0002 0.5 0.5
Brugia malayi Guanylyl cyclase protein 23 0.0002 0.5 0.5
Loa Loa (eye worm) TK/RYK protein kinase 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Echinococcus granulosus receptor type guanylyl cyclase 0.0002 0.5 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0002 0.5 0.5
Echinococcus granulosus retinal guanylyl cyclase 2 0.0002 0.5 0.5
Echinococcus granulosus tyrosine kinase 0.0002 0.5 0.5
Echinococcus granulosus tyrosine protein kinase Blk 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Plasmodium falciparum tyrosine kinase-like protein 0.0002 0.5 0.5
Brugia malayi ephrin receptor 1 precursor 0.0002 0.5 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Brugia malayi C-terminal src kinase protein 1 0.0002 0.5 0.5
Echinococcus multilocularis integrin linked protein kinase 0.0002 0.5 0.5
Entamoeba histolytica hypothetical protein 0.0002 0.5 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0002 0.5 0.5
Echinococcus granulosus tyrosine protein kinase ABL1 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Loa Loa (eye worm) TK protein kinase 0.0002 0.5 0.5
Schistosoma mansoni protein kinase 0.0002 0.5 0.5
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0002 0.5 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0002 0.5 0.5
Brugia malayi hypothetical protein 0.0002 0.5 0.5
Schistosoma mansoni protein kinase 0.0002 0.5 0.5
Loa Loa (eye worm) TK/ROR protein kinase 0.0002 0.5 0.5
Brugia malayi protein-tyrosine kinase 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0002 0.5 0.5
Onchocerca volvulus 0.0002 0.5 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0002 0.5 0.5
Entamoeba histolytica hypothetical protein 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0002 0.5 0.5
Trypanosoma cruzi protein kinase, putative 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Brugia malayi hypothetical protein 0.0002 0.5 0.5
Echinococcus multilocularis ephrin type A receptor 4 A 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Entamoeba histolytica protein kinase, putative 0.0002 0.5 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase Srms 0.0002 0.5 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0002 0.5 0.5
Entamoeba histolytica protein kinase, putative 0.0002 0.5 0.5
Brugia malayi SH2 domain containing protein 0.0002 0.5 0.5
Entamoeba histolytica cysteine surface protein, putative 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Echinococcus multilocularis heat shock protein 70 0.0002 0.5 0.5
Brugia malayi SH2 domain containing protein 0.0002 0.5 0.5
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0002 0.5 0.5
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0002 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0002 0.5 0.5
Entamoeba histolytica hypothetical protein 0.0002 0.5 0.5
Schistosoma mansoni tyrosine protein kinase 0.0002 0.5 0.5
Entamoeba histolytica serine/threonine kinase, putative 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0002 0.5 0.5
Loa Loa (eye worm) SRC-1 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0002 0.5 0.5
Trypanosoma brucei protein kinase, putative 0.0002 0.5 0.5
Entamoeba histolytica protein kinase, putative 0.0002 0.5 0.5
Echinococcus multilocularis transfer RNA-Thr 0.0002 0.5 0.5
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0002 0.5 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0002 0.5 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0002 0.5 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0002 0.5 0.5
Echinococcus multilocularis kinase suppressor of Ras 1 0.0002 0.5 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0002 0.5 0.5
Loa Loa (eye worm) TK/EGFR protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0002 0.5 0.5
Echinococcus multilocularis protein kinase 0.0002 0.5 0.5
Plasmodium vivax tyrosine kinase-like protein, putative 0.0002 0.5 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0002 0.5 0.5
Echinococcus granulosus c src tyrosine kinase 0.0002 0.5 0.5
Echinococcus granulosus tyrosine protein kinase csk 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Echinococcus multilocularis natriuretic peptide receptor 1 0.0002 0.5 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0002 0.5 0.5
Entamoeba histolytica protein kinase, putative 0.0002 0.5 0.5
Echinococcus multilocularis activin receptor type 0.0002 0.5 0.5
Entamoeba histolytica hypothetical protein 0.0002 0.5 0.5
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0002 0.5 0.5
Entamoeba histolytica protein kinase, putative 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Onchocerca volvulus 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0002 0.5 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0002 0.5 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0002 0.5 0.5
Entamoeba histolytica serine/threonine kinase, putative 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Entamoeba histolytica protein kinase, putative 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0002 0.5 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0002 0.5 0.5
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0002 0.5 0.5
Toxoplasma gondii protein kinase domain-containing protein 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0002 0.5 0.5
Echinococcus granulosus tyrosine protein kinase Src64B 0.0002 0.5 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0002 0.5 0.5
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0002 0.5 0.5
Trypanosoma brucei Pseudokinase, putative 0.0002 0.5 0.5
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0002 0.5 0.5
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Entamoeba histolytica protein kinase, putative 0.0002 0.5 0.5
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0002 0.5 0.5
Toxoplasma gondii STE kinase 0.0002 0.5 0.5
Onchocerca volvulus 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Entamoeba histolytica protein kinase, putative 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase shark 0.0002 0.5 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0002 0.5 0.5
Entamoeba histolytica protein kinase, putative 0.0002 0.5 0.5
Giardia lamblia Kinase, NEK 0.0002 0.5 0.5
Loa Loa (eye worm) serine/threonine protein kinase 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Onchocerca volvulus 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase HCK 0.0002 0.5 0.5
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0002 0.5 0.5
Echinococcus multilocularis receptor type guanylyl cyclase 0.0002 0.5 0.5
Echinococcus granulosus protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0002 0.5 0.5
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0002 0.5 0.5
Echinococcus multilocularis c src tyrosine kinase 0.0002 0.5 0.5
Loa Loa (eye worm) RGC/RGC protein kinase 0.0002 0.5 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0002 0.5 0.5
Schistosoma mansoni ephrin receptor 0.0002 0.5 0.5
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Echinococcus multilocularis protein KINase family member (kin 25) 0.0002 0.5 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0002 0.5 0.5
Echinococcus granulosus kinase suppressor of Ras 1 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0002 0.5 0.5
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0002 0.5 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Schistosoma mansoni protein tyrosine kinase 0.0002 0.5 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0002 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0002 0.5 0.5
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0002 0.5 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0002 0.5 0.5
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0002 0.5 0.5
Loa Loa (eye worm) TK/FAK protein kinase 0.0002 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0002 0.5 0.5
Schistosoma mansoni protein kinase 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0002 0.5 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.0002 0.5 0.5
Echinococcus granulosus tyrosine protein kinase Lyn 0.0002 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Brugia malayi Tyrosine-protein kinase PR2 0.0002 0.5 0.5
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0002 0.5 0.5
Loa Loa (eye worm) TK protein kinase 0.0002 0.5 0.5
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0002 0.5 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0002 0.5 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0002 0.5 0.5
Onchocerca volvulus 0.0002 0.5 0.5
Entamoeba histolytica protein kinase, putative 0.0002 0.5 0.5
Brugia malayi hypothetical protein 0.0002 0.5 0.5
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0002 0.5 0.5
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Entamoeba histolytica tyrosin kinase, putative 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine kinase 0.0002 0.5 0.5
Onchocerca volvulus 0.0002 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0002 0.5 0.5
Echinococcus granulosus tyrosine protein kinase HCK 0.0002 0.5 0.5
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0002 0.5 0.5
Schistosoma mansoni protein kinase 0.0002 0.5 0.5
Entamoeba histolytica serine/threonine kinase, putative 0.0002 0.5 0.5
Onchocerca volvulus 0.0002 0.5 0.5
Echinococcus granulosus natriuretic peptide receptor 1 0.0002 0.5 0.5
Echinococcus multilocularis insulin receptor 0.0002 0.5 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0002 0.5 0.5
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0002 0.5 0.5
Leishmania major protein kinase, putative 0.0002 0.5 0.5
Trichomonas vaginalis protein tyrosine kinase, putative 0.0002 0.5 0.5
Onchocerca volvulus 0.0002 0.5 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0002 0.5 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0002 0.5 0.5
Plasmodium falciparum protein kinase, putative 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0002 0.5 0.5
Loa Loa (eye worm) protein kinase domain-containing protein 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.0002 0.5 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0002 0.5 0.5
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0002 0.5 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0002 0.5 0.5
Echinococcus multilocularis protein kinase 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase Blk 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.0002 0.5 0.5
Echinococcus granulosus epidermal growth factor receptor 0.0002 0.5 0.5
Entamoeba histolytica ankyrin repeat protein 0.0002 0.5 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0002 0.5 0.5
Echinococcus granulosus tyrosine protein kinase pr2 0.0002 0.5 0.5
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0002 0.5 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0002 0.5 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Onchocerca volvulus 0.0002 0.5 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0002 0.5 0.5
Brugia malayi Raf kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Entamoeba histolytica protein kinase, putative 0.0002 0.5 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0002 0.5 0.5
Entamoeba histolytica tyrosin kinase, putative 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0002 0.5 0.5
Schistosoma mansoni protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Echinococcus granulosus tyrosine protein kinase Srms 0.0002 0.5 0.5
Echinococcus multilocularis tyrosine kinase 0.0002 0.5 0.5
Echinococcus granulosus tyrosine kinase 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0002 0.5 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0002 0.5 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0002 0.5 0.5
Entamoeba histolytica hypothetical protein 0.0002 0.5 0.5
Brugia malayi Protein kinase domain containing protein 0.0002 0.5 0.5
Entamoeba histolytica receptor protein kinase, putative 0.0002 0.5 0.5
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0002 0.5 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0002 0.5 0.5
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0002 0.5 0.5
Plasmodium falciparum tyrosine kinase-like protein 0.0002 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0002 0.5 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0002 0.5 0.5
Entamoeba histolytica ankyrin repeat protein 0.0002 0.5 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0002 0.5 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0002 0.5 0.5
Echinococcus granulosus activated cdc42 kinase 1 0.0002 0.5 0.5
Entamoeba histolytica hypothetical protein 0.0002 0.5 0.5
Echinococcus granulosus epidermal growth factor receptor 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Loa Loa (eye worm) TK protein kinase 0.0002 0.5 0.5
Schistosoma mansoni serine/threonine RGC 0.0002 0.5 0.5
Trichomonas vaginalis protein kinase atn1, putative 0.0002 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Trichomonas vaginalis TKL family protein kinase 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Schistosoma mansoni tyrosine kinase 0.0002 0.5 0.5
Loa Loa (eye worm) TK/INSR protein kinase 0.0002 0.5 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.1 uM Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15 mins followed by substrate addition measured after 20 mins by FRET assay ChEMBL. 27086121
IC50 (binding) > 10 uM Inhibition of recombinant KIF5B/RET (unknown origin) expressed in IL3 deficient BAF3 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay ChEMBL. 27086121

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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