Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | receptor (TNFRSF)-interacting serine-threonine kinase 1 | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Echinococcus multilocularis | netrin receptor unc 5 | 0.0052 | 0.5 | 0.5 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0052 | 0.5 | 0.5 |
Echinococcus granulosus | Ankyrin | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | Netrin receptor homolog | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0052 | 0.5 | 0.5 |
Echinococcus granulosus | death domain containing protein | 0.0052 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Schistosoma mansoni | netrin receptor unc5 | 0.0052 | 0.5 | 0.5 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0052 | 0.5 | 0.5 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0052 | 0.5 | 0.5 |
Echinococcus granulosus | netrin receptor unc 5 | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0052 | 0.5 | 0.5 |
Echinococcus multilocularis | Ankyrin | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Death domain containing protein | 0.0052 | 0.5 | 0.5 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0052 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 16 nM | Inhibition of human RIP1 (1 to 375 residues) after 4 hrs by ADP-Glo reagent based assay | ChEMBL. | 26854747 |
IC50 (binding) | = 32 nM | Binding affinity to human RIP1 (1 to 375 residues) preincubated for 10 mins measured after 20 mins by fluorescence polarization assay | ChEMBL. | 26854747 |
IC50 (binding) | = 200 nM | Inhibition of human RIP1 in human U937 cells assessed as inhibition of TNF/zVAD.fmk induced necroptosis after 24 hrs by Cell titer-Glo luminescence assay | ChEMBL. | 26854747 |
K (binding) | = 1.1 /uM/s | Binding affinity to human RIP1 (1 to 375 residues) by stopped flow kinetic study | ChEMBL. | 26854747 |
T1/2 (binding) | < 5 min | Binding affinity to human RIP1 (1 to 375 residues) assessed as half life preincubated for 10 mins measured after 20 mins by fluorescence polarization assay | ChEMBL. | 26854747 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.