Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | serine/threonine-protein kinase 3, putative | 0.0063 | 0.2255 | 0.4991 |
Giardia lamblia | Kinase, STE STE20 | 0.0063 | 0.2255 | 0.5 |
Loa Loa (eye worm) | STE/STE20/YSK protein kinase | 0.0124 | 0.4517 | 0.4517 |
Onchocerca volvulus | Mitochondrial Rho GTPase homolog | 0.0003 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0124 | 0.4517 | 1 |
Echinococcus granulosus | serine:threonine protein kinase 3 | 0.027 | 1 | 1 |
Leishmania major | protein kinase, putative | 0.0063 | 0.2255 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0124 | 0.4517 | 1 |
Echinococcus granulosus | leucine rich repeat serine:threonine protein | 0.0072 | 0.2573 | 0.2573 |
Trypanosoma brucei | STE20-like serine/threonine-protein kinase 1, putative | 0.0063 | 0.2255 | 1 |
Onchocerca volvulus | 0.0003 | 0 | 0.5 | |
Echinococcus multilocularis | myosin iiia | 0.0063 | 0.2255 | 0.2255 |
Echinococcus multilocularis | leucine rich repeat serine:threonine protein | 0.0071 | 0.2555 | 0.2555 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0124 | 0.4517 | 0.4517 |
Echinococcus granulosus | serine threonine protein kinase | 0.0124 | 0.4517 | 0.4517 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0124 | 0.4517 | 0.5886 |
Trichomonas vaginalis | STE family protein kinase | 0.0063 | 0.2255 | 0.4991 |
Loa Loa (eye worm) | STE/STE20/MST protein kinase | 0.027 | 1 | 1 |
Entamoeba histolytica | serine/threonine protein kinase STE20, putative | 0.0063 | 0.2255 | 0.4991 |
Plasmodium falciparum | protein kinase, putative | 0.0124 | 0.4517 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0071 | 0.2555 | 0.2555 |
Loa Loa (eye worm) | TKL/LRRK protein kinase | 0.0071 | 0.2555 | 0.2555 |
Schistosoma mansoni | ste20-related kinase | 0.0208 | 0.7674 | 1 |
Trypanosoma cruzi | STE/STE20 serine/threonine-protein kinase, putative | 0.0063 | 0.2255 | 1 |
Trypanosoma cruzi | STE/STE20 serine/threonine-protein kinase, putative | 0.0063 | 0.2255 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0124 | 0.4517 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 3 | 0.027 | 1 | 1 |
Plasmodium vivax | serine/threonine-specific protein kinase, putative | 0.0124 | 0.4517 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.