Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | fibroblast activation protein | No references | |
Homo sapiens | prolyl endopeptidase | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | oligopeptidase b | prolyl endopeptidase | 710 aa | 630 aa | 27.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0175 | 0.6507 | 0.632 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0087 | 0.051 | 0.0784 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0226 | 1 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0087 | 0.051 | 0.0784 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0175 | 0.6507 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0175 | 0.6507 | 0.632 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0175 | 0.6507 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0226 | 1 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0079 | 0 | 0.5 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0079 | 0 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0226 | 1 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0226 | 1 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0175 | 0.6507 | 0.632 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0175 | 0.6507 | 0.632 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0087 | 0.051 | 0.0784 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0226 | 1 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.0175 | 0.6507 | 1 |
Trypanosoma brucei | prolyl endopeptidase | 0.0175 | 0.6507 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0175 | 0.6507 | 0.632 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0142 | 0.4241 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0087 | 0.051 | 0.0784 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0087 | 0.051 | 0.0784 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3600 nM | Enzymatic Assay | BINDINGDB. | No reference |
IC50 (binding) | = 13200 nM | Enzymatic Assay | BINDINGDB. | No reference |
IC50 (binding) | > 25000 nM | Enzymatic Assay | BINDINGDB. | No reference |
IC50 (binding) | > 100000 nM | Enzymatic Assay | BINDINGDB. | No reference |
IC50 (binding) | > 100000 nM | Enzymatic Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.