Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific demethylase 1A | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0133 | 0.1738 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0067 | 0.083 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0067 | 0.083 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0067 | 0.083 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0067 | 0.083 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0133 | 0.1738 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0067 | 0.083 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0067 | 0.083 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1834 | 0.6698 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0067 | 0.083 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0067 | 0.083 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.083 | 0.303 |
Leishmania major | UDP-galactopyranose mutase | 0.0067 | 0.083 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0926 | 0.3382 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.1738 | 0.6346 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0074 | 0.0926 | 0.3485 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0133 | 0.1738 | 1 |
Brugia malayi | hypothetical protein | 0.0067 | 0.083 | 0.3122 |
Echinococcus multilocularis | 0.0067 | 0.083 | 0.4775 | |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.2658 | 0.9706 |
Onchocerca volvulus | CoRest homolog | 0.0206 | 0.2738 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0667 | 0.9074 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.014 | 0.1834 | 0.6901 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0734 | 1 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0067 | 0.083 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0067 | 0.083 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.083 | 0.303 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0067 | 0.083 | 0.4775 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0067 | 0.083 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0067 | 0.083 | 0.4775 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0067 | 0.083 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.2738 | 1 |
Schistosoma mansoni | amine oxidase | 0.0067 | 0.083 | 0.4775 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.02 | 0.2658 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0067 | 0.083 | 0.4775 |
Schistosoma mansoni | amine oxidase | 0.0067 | 0.083 | 0.4775 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.1738 | 0.6346 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0067 | 0.083 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 17 nM | Biological Assay | BINDINGDB. | No reference |
IC50 (binding) | = 33 nM | Biological Assay | BINDINGDB. | No reference |
IC50 (binding) | = 44170 nM | Fluorescence-Based (Inhibitor)-Screening Assay | BINDINGDB. | No reference |
IC50 (binding) | > 100000 nM | Fluorescence-Based (Inhibitor)-Screening Assay | BINDINGDB. | No reference |
IC50 (binding) | > 100000 nM | Fluorescence-Based (Inhibitor)-Screening Assay | BINDINGDB. | No reference |
IC50 (binding) | > 100000 nM | Fluorescence-Based (Inhibitor)-Screening Assay | BINDINGDB. | No reference |
Ki (binding) | = 50 nM | Biological Assay | BINDINGDB. | No reference |
Ki (binding) | = 50 nM | Biological Assay | BINDINGDB. | No reference |
Ki (binding) | > 40000 nM | Fluorescence-Based (Inhibitor)-Screening Assay | BINDINGDB. | No reference |
Ki (binding) | > 40000 nM | Fluorescence-Based (Inhibitor)-Screening Assay | BINDINGDB. | No reference |
Ki (binding) | > 40000 nM | Fluorescence-Based (Inhibitor)-Screening Assay | BINDINGDB. | No reference |
Ki (binding) | > 40000 nM | Fluorescence-Based (Inhibitor)-Screening Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.