Detailed information for compound 216080

Basic information

Technical information
  • TDR Targets ID: 216080
  • Name: (2R)-2-[[6-(cyclohexylmethoxy)-7H-purin-2-yl] amino]butan-1-ol
  • MW: 319.402 | Formula: C16H25N5O2
  • H donors: 3 H acceptors: 4 LogP: 3.37 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[C@@H](Nc1nc(OCC2CCCCC2)c2c(n1)nc[nH]2)CO
  • InChi: 1S/C16H25N5O2/c1-2-12(8-22)19-16-20-14-13(17-10-18-14)15(21-16)23-9-11-6-4-3-5-7-11/h10-12,22H,2-9H2,1H3,(H2,17,18,19,20,21)/t12-/m1/s1
  • InChiKey: ATCWGIMKCXRHFT-GFCCVEGCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R)-2-[[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino]-1-butanol
  • O6-Cyclohexylmethylguanine deriv. 11

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi G protein-coupled receptor 0.0551 0.213 0.213
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0551 0.213 0.2289
Onchocerca volvulus 0.0551 0.213 1
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Echinococcus granulosus g-protein coupled receptor 0.0551 0.213 0.4666
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0551 0.213 0.2289
Echinococcus multilocularis dual specificity 0.0089 0.019 0.0204
Echinococcus multilocularis fmrfamide receptor 0.0551 0.213 0.2289
Loa Loa (eye worm) hypothetical protein 0.0088 0.0187 0.0187
Onchocerca volvulus 0.0551 0.213 1
Brugia malayi neuropeptide F receptor 0.0551 0.213 0.213
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Trypanosoma brucei beta lactamase 0.0154 0.0465 0.4483
Schistosoma mansoni neuropeptide F-like receptor 0.0551 0.213 0.2289
Onchocerca volvulus 0.0551 0.213 1
Echinococcus granulosus serotonin receptor 0.0551 0.213 0.4666
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0551 0.213 0.2289
Echinococcus granulosus tm gpcr rhodopsin 0.0551 0.213 0.4666
Leishmania major histone deacetylase, putative 0.0075 0.0132 0.1268
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Echinococcus granulosus neuropeptide receptor 0.0551 0.213 0.4666
Brugia malayi Melatonin receptor type 1A 0.0551 0.213 0.213
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Brugia malayi hypothetical protein 0.0551 0.213 0.213
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0551 0.213 0.2289
Echinococcus granulosus rhodopsin orphan GPCR 0.0551 0.213 0.4666
Brugia malayi hypothetical protein 0.0551 0.213 0.213
Brugia malayi hypothetical protein 0.0551 0.213 0.213
Trypanosoma brucei histone deacetylase 4 0.0075 0.0132 0.1268
Echinococcus multilocularis allatostatin A receptor 0.0551 0.213 0.2289
Brugia malayi hypothetical protein 0.0551 0.213 0.213
Echinococcus multilocularis neuropeptides capa receptor 0.0551 0.213 0.2289
Echinococcus multilocularis histone deacetylase 0.0075 0.0132 0.0141
Echinococcus multilocularis rhodopsin orphan GPCR 0.0551 0.213 0.2289
Echinococcus multilocularis integrin alpha 3 0.0495 0.1896 0.2037
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Echinococcus granulosus histone deacetylase 0.0075 0.0132 0.0288
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0551 0.213 0.213
Schistosoma mansoni biogenic amine receptor 0.0551 0.213 0.2289
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0059 0.0065 0.007
Echinococcus multilocularis g protein coupled receptor 0.0551 0.213 0.2289
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0551 0.213 0.2289
Entamoeba histolytica DNA repair and recombination protein, putative 0.0291 0.1038 1
Echinococcus multilocularis neuropeptide s receptor 0.0551 0.213 0.2289
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Onchocerca volvulus 0.0551 0.213 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0551 0.213 0.213
Schistosoma mansoni biogenic amine (5HT) receptor 0.1131 0.4565 0.4906
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0551 0.213 0.2289
Echinococcus granulosus neuropeptide s receptor 0.0551 0.213 0.4666
Echinococcus multilocularis dro:myosuppressin receptor 0.0551 0.213 0.2289
Onchocerca volvulus 0.0551 0.213 1
Schistosoma mansoni neuropeptide receptor 0.0551 0.213 0.2289
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0551 0.213 0.2289
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Schistosoma mansoni biogenic amine receptor 0.0551 0.213 0.2289
Echinococcus multilocularis fmrfamide receptor 0.0551 0.213 0.2289
Echinococcus multilocularis integrin beta 2 0.098 0.3932 0.4226
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0201 0.0661 0.0661
Brugia malayi Serotonin receptor 0.0551 0.213 0.213
Trypanosoma brucei histone deacetylase, putative 0.0075 0.0132 0.1268
Onchocerca volvulus 0.0551 0.213 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0059 0.0065 0.007
Schistosoma mansoni histone deacetylase hda2 0.0086 0.018 0.0193
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0322 0.1168 1
Echinococcus granulosus neuropeptide Y receptor 0.0551 0.213 0.4666
Schistosoma mansoni hypothetical protein 0.0551 0.213 0.2289
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0089 0.019 0.1829
Loa Loa (eye worm) hypothetical protein 0.0088 0.0187 0.0187
Brugia malayi Serotonin receptor 0.0551 0.213 0.213
Schistosoma mansoni hypothetical protein 0.0551 0.213 0.2289
Loa Loa (eye worm) integrin alpha pat-2 0.0996 0.3997 0.3997
Echinococcus granulosus integrin beta 2 0.098 0.3932 0.8612
Echinococcus multilocularis rhodopsin orphan GPCR 0.0551 0.213 0.2289
Echinococcus multilocularis integrin alpha ps 0.029 0.1033 0.111
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0551 0.213 0.2289
Loa Loa (eye worm) hypothetical protein 0.0151 0.045 0.045
Onchocerca volvulus 0.0551 0.213 1
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Schistosoma mansoni biogenic amine receptor 0.0551 0.213 0.2289
Brugia malayi hypothetical protein 0.0551 0.213 0.213
Brugia malayi putative neuropeptide receptor NPR1 0.0551 0.213 0.213
Echinococcus granulosus neuropeptide FF receptor 2 0.0551 0.213 0.4666
Echinococcus multilocularis integrin alpha ps 0.029 0.1033 0.111
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0291 0.1038 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0551 0.213 0.2289
Trichomonas vaginalis conserved hypothetical protein 0.0291 0.1038 0.5494
Echinococcus granulosus histone deacetylase 6 0.0075 0.0132 0.0288
Onchocerca volvulus 0.0551 0.213 1
Echinococcus multilocularis fibrillin 1 0.0053 0.0039 0.0042
Schistosoma mansoni neuropeptide F-like receptor 0.0551 0.213 0.2289
Echinococcus multilocularis rhodopsin orphan GPCR 0.0551 0.213 0.2289
Trypanosoma cruzi histone deacetylase, putative 0.0075 0.0132 0.1268
Schistosoma mansoni amine GPCR 0.0551 0.213 0.2289
Echinococcus granulosus allatostatin A receptor 0.0551 0.213 0.4666
Schistosoma mansoni growth hormone secretagogue receptor 0.0551 0.213 0.2289
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0059 0.0065 0.0143
Echinococcus granulosus rhodopsin orphan GPCR 0.0551 0.213 0.4666
Schistosoma mansoni hypothetical protein 0.0551 0.213 0.2289
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0551 0.213 0.2289
Loa Loa (eye worm) calpain family protein 1 0.0057 0.0054 0.0054
Echinococcus granulosus orexin receptor type 2 0.0551 0.213 0.4666
Echinococcus granulosus calpain A 0.0059 0.0065 0.0143
Loa Loa (eye worm) histone deacetylase 0.0075 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0489 0.1868 0.1868
Brugia malayi Tachykinin-like peptides receptor 99D 0.0551 0.213 0.213
Brugia malayi Histone deacetylase family protein 0.0075 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0356 0.1313 0.1313
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0059 0.0065 0.007
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0291 0.1038 1
Onchocerca volvulus 0.0551 0.213 1
Onchocerca volvulus 0.0551 0.213 1
Echinococcus multilocularis neuropeptide receptor 0.0551 0.213 0.2289
Plasmodium falciparum histone deacetylase 2 0.0075 0.0132 0.5
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0291 0.1038 1
Schistosoma mansoni neuropeptide receptor 0.0551 0.213 0.2289
Brugia malayi G-protein coupled receptor 0.0551 0.213 0.213
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0154 0.0465 1
Schistosoma mansoni neuropeptide receptor 0.0551 0.213 0.2289
Brugia malayi G protein-coupled receptor F59B2.13 0.0551 0.213 0.213
Brugia malayi AKH receptor 0.0551 0.213 0.213
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0489 0.1868 0.1868
Echinococcus multilocularis sex peptide receptor 0.0551 0.213 0.2289
Trypanosoma brucei histone deacetylase 3 0.0075 0.0132 0.1268
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0551 0.213 0.213
Echinococcus granulosus g protein coupled receptor 0.0551 0.213 0.4666
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0551 0.213 0.2289
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0551 0.213 0.2289
Echinococcus granulosus histone deacetylase 6 0.0086 0.018 0.0394
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0551 0.213 0.2289
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Loa Loa (eye worm) hypothetical protein 0.0598 0.2326 0.2326
Loa Loa (eye worm) G-protein coupled receptor 0.0551 0.213 0.213
Brugia malayi putative neuropeptide receptor 0.0551 0.213 0.213
Echinococcus granulosus biogenic amine 5HT receptor 0.1131 0.4565 1
Echinococcus granulosus g protein coupled receptor 0.0551 0.213 0.4666
Loa Loa (eye worm) melatonin receptor type 1A 0.0551 0.213 0.213
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Brugia malayi Protein kinase domain containing protein 0.0089 0.019 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0493 0.1888 1
Brugia malayi NNMT/PNMT/TEMT family protein 0.0598 0.2326 0.2326
Echinococcus multilocularis histone deacetylase 6 0.0086 0.018 0.0193
Brugia malayi Dopamine receptor protein 2 0.0551 0.213 0.213
Loa Loa (eye worm) hypothetical protein 0.0507 0.1946 0.1946
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Echinococcus multilocularis integrin alpha ps 0.0139 0.04 0.0429
Echinococcus granulosus neuropeptides capa receptor 0.0551 0.213 0.4666
Echinococcus multilocularis somatostatin receptor 0.0551 0.213 0.2289
Loa Loa (eye worm) hypothetical protein 0.2425 1 1
Echinococcus multilocularis histone deacetylase 7 0.0075 0.0132 0.0141
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Echinococcus granulosus hypothetical protein 0.0551 0.213 0.4666
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Brugia malayi sulfakinin receptor protein 0.0551 0.213 0.213
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0316 0.1142 0.9785
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0551 0.213 0.213
Schistosoma mansoni integrin alpha-ps 0.0151 0.045 0.0483
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0551 0.213 0.4666
Echinococcus multilocularis neuropeptide Y receptor 0.0551 0.213 0.2289
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0291 0.1038 0.1115
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0551 0.213 0.2289
Entamoeba histolytica hypothetical protein, conserved 0.0291 0.1038 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0551 0.213 0.213
Echinococcus multilocularis rhodopsin orphan GPCR 0.0551 0.213 0.2289
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0294 0.1049 0.8985
Onchocerca volvulus 0.0551 0.213 1
Brugia malayi hypothetical protein 0.0551 0.213 0.213
Echinococcus multilocularis G-protein coupled receptor, putative 0.0551 0.213 0.2289
Brugia malayi Probable ATP-dependent helicase DHX35 0.0065 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0551 0.213 0.2289
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0551 0.213 0.213
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0551 0.213 0.4666
Onchocerca volvulus 0.0551 0.213 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0551 0.213 0.2289
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Schistosoma mansoni integrin alpha-ps 0.029 0.1033 0.111
Schistosoma mansoni alpha-1 adrenergic receptor 0.0551 0.213 0.2289
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0089 0.019 0.1829
Giardia lamblia Rrm3p helicase 0.0291 0.1038 0.5
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0551 0.213 0.213
Onchocerca volvulus 0.0551 0.213 1
Echinococcus granulosus neuropeptide Y receptor 0.0551 0.213 0.4666
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0551 0.213 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0551 0.213 0.213
Loa Loa (eye worm) hypothetical protein 0.0065 0.0089 0.0089
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0551 0.213 0.2289
Loa Loa (eye worm) hypothetical protein 0.005 0.0027 0.0027
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0551 0.213 0.2289
Echinococcus multilocularis neuropeptide receptor A26 0.0551 0.213 0.2289
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Loa Loa (eye worm) neuropeptide F receptor 0.0551 0.213 0.213
Trypanosoma cruzi histone deacetylase, putative 0.0075 0.0132 0.1268
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Echinococcus multilocularis orexin receptor type 2 0.0551 0.213 0.2289
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0551 0.213 0.2289
Schistosoma mansoni histone deacetylase 4 5 0.0075 0.0132 0.0141
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0316 0.1142 0.9785
Loa Loa (eye worm) hypothetical protein 0.0064 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Schistosoma mansoni integrin beta subunit 0.0779 0.3088 0.3318
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0089 0.019 0.1829
Echinococcus multilocularis rhodopsin orphan GPCR 0.0551 0.213 0.2289
Echinococcus granulosus neuropeptides capa receptor 0.0551 0.213 0.4666
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Echinococcus granulosus integrin alpha ps 0.0139 0.04 0.0875
Schistosoma mansoni amine GPCR 0.0551 0.213 0.2289
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0551 0.213 0.4666
Schistosoma mansoni opsin-like receptor 0.0551 0.213 0.2289
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Onchocerca volvulus 0.0551 0.213 1
Brugia malayi hypothetical protein 0.0551 0.213 0.213
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0551 0.213 0.2289
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0551 0.213 0.4666
Brugia malayi neuropeptide F receptor 0.0551 0.213 0.213
Brugia malayi Integrin alpha pat-2 precursor 0.0646 0.2529 0.2529
Brugia malayi RE15519p 0.0551 0.213 0.213
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0057 0.0054 0.0058
Brugia malayi ORL1-like opioid receptor 0.0551 0.213 0.213
Echinococcus multilocularis serotonin receptor 0.1131 0.4565 0.4906
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0551 0.213 0.2289
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0154 0.0465 0.3984
Echinococcus granulosus G protein coupled receptor 139 0.0551 0.213 0.4666
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0551 0.213 0.2289
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0551 0.213 0.2289
Plasmodium vivax histone deacetylase, putative 0.0075 0.0132 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0054 0.0054
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0291 0.1038 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0551 0.213 0.4666
Trypanosoma cruzi histone deacetylase, putative 0.0075 0.0132 0.1268
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Plasmodium vivax histone deacetylase 2, putative 0.0075 0.0132 1
Brugia malayi G-protein coupled receptor 0.0551 0.213 0.213
Echinococcus granulosus tm gpcr rhodopsin 0.0551 0.213 0.4666
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0551 0.213 0.4666
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Echinococcus multilocularis g protein coupled receptor 0.0551 0.213 0.2289
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Brugia malayi hypothetical protein 0.0201 0.0661 0.0661
Toxoplasma gondii histone deacetylase HDAC1 0.0075 0.0132 1
Echinococcus multilocularis neuropeptide receptor 0.0551 0.213 0.2289
Onchocerca volvulus 0.0551 0.213 1
Echinococcus granulosus histone deacetylase 6 0.0075 0.0132 0.0288
Plasmodium falciparum histone deacetylase, putative 0.0075 0.0132 0.5
Brugia malayi hypothetical protein 0.0551 0.213 0.213
Loa Loa (eye worm) histone deacetylase 7A 0.0075 0.0132 0.0132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0551 0.213 0.2289
Schistosoma mansoni biogenic amine (5HT) receptor 0.0551 0.213 0.2289
Brugia malayi calpain family protein 1 0.0057 0.0054 0.0054
Echinococcus granulosus neuropeptide receptor A26 0.0551 0.213 0.4666
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.018 0.0194
Echinococcus granulosus alpha 1A adrenergic receptor 0.0551 0.213 0.4666
Mycobacterium ulcerans lipoprotein LpqF 0.0154 0.0465 0.3984
Echinococcus granulosus neuropeptide receptor 0.0551 0.213 0.4666
Echinococcus multilocularis neuropeptide FF receptor 2 0.0551 0.213 0.2289
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0551 0.213 0.2289
Echinococcus multilocularis G protein coupled receptor 139 0.0551 0.213 0.2289
Brugia malayi Histone deacetylase family protein 0.0075 0.0132 0.0132
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0551 0.213 0.213
Echinococcus multilocularis rhodopsin orphan GPCR 0.0551 0.213 0.2289
Loa Loa (eye worm) DEAH box polypeptide 35 0.0065 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0201 0.0661 0.0661
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Echinococcus granulosus tachykinin peptides receptor 99D 0.0551 0.213 0.4666
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0551 0.213 0.2289
Schistosoma mansoni amine GPCR 0.0551 0.213 0.2289
Loa Loa (eye worm) hypothetical protein 0.0139 0.04 0.04
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0551 0.213 0.2289
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0551 0.213 0.213
Brugia malayi calpain family protein 1 0.0057 0.0054 0.0054
Echinococcus multilocularis Zinc finger, DBF type 0.226 0.9305 1
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Brugia malayi Protein kinase domain containing protein 0.0087 0.018 0.018
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0551 0.213 0.2289
Echinococcus multilocularis calpain A 0.0059 0.0065 0.007
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Schistosoma mansoni amine GPCR 0.0551 0.213 0.2289
Leishmania major histone deacetylase, putative 0.0075 0.0132 0.1268
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Brugia malayi Integrin beta pat-3 precursor 0.1323 0.5372 0.5372
Onchocerca volvulus Neuropeptide F receptor homolog 0.0551 0.213 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0551 0.213 0.2289
Schistosoma mansoni integrin alpha 0.0646 0.2529 0.2718
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0291 0.1038 0.2273
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0279 0.0987 0.8457
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Echinococcus granulosus 7TM GPCR rhodopsin 0.0551 0.213 0.4666
Echinococcus granulosus 7tm_1 domain containing protein 0.0551 0.213 0.4666
Echinococcus multilocularis histone deacetylase 6 0.0075 0.0132 0.0141
Loa Loa (eye worm) hypothetical protein 0.1131 0.4565 0.4565
Echinococcus multilocularis g protein coupled receptor 0.0551 0.213 0.2289
Brugia malayi hypothetical protein 0.0551 0.213 0.213
Loa Loa (eye worm) hypothetical protein 0.0052 0.0037 0.0037
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.019 0.0204
Echinococcus granulosus Zinc finger DBF type 0.0493 0.1888 0.4136
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0551 0.213 0.2289
Loa Loa (eye worm) hypothetical protein 0.1131 0.4565 0.4565
Schistosoma mansoni hypothetical protein 0.226 0.9305 1
Loa Loa (eye worm) integrin beta-2 0.1323 0.5372 0.5372
Echinococcus granulosus biogenic amine 5HT receptor 0.0551 0.213 0.4666
Schistosoma mansoni neuropeptide receptor 0.0551 0.213 0.2289
Schistosoma mansoni opsin-like receptor 0.0551 0.213 0.2289
Onchocerca volvulus 0.0551 0.213 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0551 0.213 0.2289
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0291 0.1038 1
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0089 0.019 0.1829
Brugia malayi GnHR receptor homolog 0.0551 0.213 0.213
Echinococcus granulosus integrin alpha ps 0.029 0.1033 0.2262
Echinococcus granulosus g protein coupled receptor 0.0551 0.213 0.4666
Trichomonas vaginalis conserved hypothetical protein 0.0493 0.1888 1
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0291 0.1038 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0551 0.213 0.2289
Schistosoma mansoni neuropeptide f receptor 76f 0.0551 0.213 0.2289
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0551 0.213 0.2289
Brugia malayi follicle stimulating hormone receptor 0.0551 0.213 0.213
Schistosoma mansoni histone deacetylase 4 5 0.0075 0.0132 0.0141
Echinococcus granulosus rhodopsin orphan GPCR 0.0551 0.213 0.4666
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0089 0.019 0.019
Echinococcus granulosus sex peptide receptor 0.0551 0.213 0.4666
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0551 0.213 0.2289
Echinococcus granulosus dual specificity 0.0089 0.019 0.0416
Schistosoma mansoni hypothetical protein 0.0551 0.213 0.2289
Echinococcus multilocularis histone deacetylase 6 0.0075 0.0132 0.0141
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Schistosoma mansoni adenoreceptor 0.0551 0.213 0.2289
Echinococcus granulosus rhodopsin orphan GPCR 0.0551 0.213 0.4666
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0551 0.213 0.2289
Echinococcus multilocularis neuropeptide Y receptor 0.0551 0.213 0.2289
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Echinococcus granulosus rhodopsin orphan GPCR 0.0551 0.213 0.4666
Brugia malayi Kelch motif family protein 0.0201 0.0661 0.0661
Loa Loa (eye worm) G-protein coupled receptor 0.0551 0.213 0.213
Schistosoma mansoni myosin xvIII 0.0551 0.213 0.2289
Loa Loa (eye worm) TYRA-2 protein 0.0551 0.213 0.213
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein 0.0598 0.2326 0.2326
Echinococcus granulosus rhodopsin orphan GPCR 0.0551 0.213 0.4666
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0322 0.1168 1
Echinococcus granulosus integrin alpha 3 0.0495 0.1896 0.4152
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0551 0.213 0.2289
Brugia malayi Dopamine receptor 0.0551 0.213 0.213
Echinococcus multilocularis neuropeptides capa receptor 0.0551 0.213 0.2289
Loa Loa (eye worm) hypothetical protein 0.0598 0.2326 0.2326
Echinococcus granulosus peptide allatostatin:somatostatin 0.0551 0.213 0.4666
Echinococcus granulosus dro:myosuppressin receptor 0.0551 0.213 0.4666
Echinococcus granulosus tm gpcr rhodopsin 0.0551 0.213 0.4666
Echinococcus granulosus somatostatin receptor 0.0551 0.213 0.4666
Onchocerca volvulus 0.0551 0.213 1
Schistosoma mansoni opsin-like receptor 0.0551 0.213 0.2289
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0087 0.018 0.018
Schistosoma mansoni hypothetical protein 0.0291 0.1038 0.1115
Echinococcus granulosus fmrfamide receptor 0.0551 0.213 0.4666
Echinococcus multilocularis serotonin receptor 0.1131 0.4565 0.4906
Loa Loa (eye worm) hypothetical protein 0.0551 0.213 0.213
Schistosoma mansoni histamine h1 receptor 0.0551 0.213 0.2289
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0551 0.213 0.2289
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0291 0.1038 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0551 0.213 0.4666
Brugia malayi larval opioid receptor 0.0551 0.213 0.213
Echinococcus multilocularis g-protein coupled receptor 0.0551 0.213 0.2289
Echinococcus granulosus histone deacetylase 7 0.0075 0.0132 0.0288
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0551 0.213 0.2289
Schistosoma mansoni amine GPCR 0.0551 0.213 0.2289
Loa Loa (eye worm) neuropeptide F receptor 0.0551 0.213 0.213
Schistosoma mansoni hypothetical protein 0.0139 0.04 0.0429
Brugia malayi hypothetical protein 0.0551 0.213 0.213

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 43 % Inhibition of Cyclin-dependent kinase 1-cyclin B at 10 uM ChEMBL. 15239650
Inhibition (binding) = 43 % Inhibition of Cyclin-dependent kinase 1-cyclin B at 10 uM ChEMBL. 15239650
Inhibition (binding) = 62 % Inhibition of Cyclin-dependent kinase 2-Cyclin A3 at 10 uM ChEMBL. 15239650
Inhibition (binding) = 62 % Inhibition of Cyclin-dependent kinase 2-Cyclin A3 at 10 uM ChEMBL. 15239650

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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