Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 protease | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | Get druggable targets OG5_131408 | All targets in OG5_131408 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | PAN domain-containing protein | 0.139 | 0.495 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.1071 | 0.3383 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.1071 | 0.3383 | 0.3397 |
Brugia malayi | Protein kinase domain containing protein | 0.1071 | 0.3383 | 0.3397 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.1071 | 0.3383 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1071 | 0.3383 | 0.5 |
Onchocerca volvulus | 0.2026 | 0.8077 | 0.811 | |
Brugia malayi | Trypsin family protein | 0.2409 | 0.996 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.1071 | 0.3383 | 1 |
Onchocerca volvulus | 0.1071 | 0.3383 | 0.3397 | |
Onchocerca volvulus | 0.2409 | 0.996 | 1 | |
Mycobacterium ulcerans | hypothetical protein | 0.0383 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2409 | 0.996 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0387 | 0.002 | 0.002 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.2409 | 0.996 | 0.996 |
Toxoplasma gondii | PAN domain-containing protein | 0.139 | 0.495 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2409 | 0.996 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1071 | 0.3383 | 0.3397 |
Schistosoma mansoni | hypothetical protein | 0.1071 | 0.3383 | 0.3383 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.1071 | 0.3383 | 1 |
Brugia malayi | Kringle domain containing protein | 0.1071 | 0.3383 | 0.3397 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.1528 | 0.5627 | 0.5627 |
Leishmania major | hypothetical protein, conserved | 0.1071 | 0.3383 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | uM | inhibitory activity against purified HIV-1 protease in a standardized spectrophotometric assay expressed in E. coli; ni=no inhibition | ChEMBL. | 9748353 |
IC50 (binding) | 0 uM | inhibitory activity against purified HIV-1 protease in a standardized spectrophotometric assay expressed in E. coli; ni=no inhibition | ChEMBL. | 9748353 |
Kd (binding) | = 27.4 nM | Equilibrium constant for the interaction between inhibitor and HIV-1 Protease | ChEMBL. | 12459011 |
Kd (binding) | = 27.4 nM | Equilibrium constant for the interaction between inhibitor and HIV-1 Protease | ChEMBL. | 12459011 |
Ki (binding) | = 2.3 nM | Inhibition constant against HIV-1 Protease | ChEMBL. | 12459011 |
Ki (binding) | = 2.3 nM | Inhibitory activity against purified HIV-1 protease expressed in E. coli in sensitive fluorometric assay | ChEMBL. | 9748353 |
Ki (binding) | = 2.3 nM | Inhibition constant against HIV-1 Protease | ChEMBL. | 12459011 |
Ki (binding) | = 2.3 nM | Inhibitory activity against purified HIV-1 protease expressed in E. coli in sensitive fluorometric assay | ChEMBL. | 9748353 |
koff (binding) | = 13.7 s-1 | Dissociation rate constant for the interaction between inhibitor and HIV-1 protease | ChEMBL. | 12459011 |
kon (binding) | = 205000000 M-1 s-1 | Association rate constant for the interaction between inhibitor and HIV-1 protease | ChEMBL. | 12459011 |
k_off (binding) | = 13.7 s-1 | Dissociation rate constant for the interaction between inhibitor and HIV-1 protease | ChEMBL. | 12459011 |
k_on (binding) | = 205000000 M-1 s-1 | Association rate constant for the interaction between inhibitor and HIV-1 protease | ChEMBL. | 12459011 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.