Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific demethylase 1A | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | 0.0067 | 0.083 | 0.4775 | |
Brugia malayi | hypothetical protein | 0.0067 | 0.083 | 0.3122 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0133 | 0.1738 | 1 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0074 | 0.0926 | 0.3485 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.1738 | 0.6346 |
Brugia malayi | SWIRM domain containing protein | 0.014 | 0.1834 | 0.6901 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0667 | 0.9074 | 1 |
Onchocerca volvulus | CoRest homolog | 0.0206 | 0.2738 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.2658 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.2738 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0067 | 0.083 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0067 | 0.083 | 0.4775 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0067 | 0.083 | 0.4775 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.083 | 0.303 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0067 | 0.083 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0067 | 0.083 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0067 | 0.083 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0734 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.1738 | 0.6346 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0067 | 0.083 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0067 | 0.083 | 0.4775 |
Schistosoma mansoni | amine oxidase | 0.0067 | 0.083 | 0.4775 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.02 | 0.2658 | 1 |
Schistosoma mansoni | amine oxidase | 0.0067 | 0.083 | 0.4775 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0067 | 0.083 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0067 | 0.083 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0133 | 0.1738 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0067 | 0.083 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0067 | 0.083 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0067 | 0.083 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0067 | 0.083 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0133 | 0.1738 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0926 | 0.3382 |
Leishmania major | UDP-galactopyranose mutase | 0.0067 | 0.083 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.083 | 0.303 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0067 | 0.083 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0067 | 0.083 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1834 | 0.6698 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 135 nM | Biological Assay | BINDINGDB. | No reference |
IC50 (binding) | = 292 nM | Biological Assay | BINDINGDB. | No reference |
IC50 (binding) | > 100000 nM | Fluorescence-Based (Inhibitor)-Screening Assay | BINDINGDB. | No reference |
IC50 (binding) | > 100000 nM | Fluorescence-Based (Inhibitor)-Screening Assay | BINDINGDB. | No reference |
IC50 (binding) | > 100000 nM | Fluorescence-Based (Inhibitor)-Screening Assay | BINDINGDB. | No reference |
IC50 (binding) | > 100000 nM | Fluorescence-Based (Inhibitor)-Screening Assay | BINDINGDB. | No reference |
Ki (binding) | = 550 nM | Biological Assay | BINDINGDB. | No reference |
Ki (binding) | = 550 nM | Biological Assay | BINDINGDB. | No reference |
Ki (binding) | > 40000 nM | Fluorescence-Based (Inhibitor)-Screening Assay | BINDINGDB. | No reference |
Ki (binding) | > 40000 nM | Fluorescence-Based (Inhibitor)-Screening Assay | BINDINGDB. | No reference |
Ki (binding) | > 40000 nM | Fluorescence-Based (Inhibitor)-Screening Assay | BINDINGDB. | No reference |
Ki (binding) | > 40000 nM | Fluorescence-Based (Inhibitor)-Screening Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.