Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Fructose-1,6-bisphosphatase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Neospora caninum | fructose-1,6-bisphosphatase, putative | Fructose-1,6-bisphosphatase | 363 aa | 298 aa | 32.5 % |
Onchocerca volvulus | CES-1 homolog | Fructose-1,6-bisphosphatase | 363 aa | 319 aa | 60.5 % |
Toxoplasma gondii | fructose-bisphospatase I | Fructose-1,6-bisphosphatase | 363 aa | 326 aa | 31.3 % |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.34 uM | Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat double mutant (Gln50Lys Gln55His) enzyme using malachite green assay | ChEMBL. | 12190310 |
IC50 (binding) | = 0.34 uM | Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat double mutant (Gln50Lys Gln55His) enzyme using malachite green assay | ChEMBL. | 12190310 |
IC50 (binding) | = 0.83 uM | Inhibition of human recombinant wild type fructose-1,6-bisphosphatase (F16BP) | ChEMBL. | 12190310 |
IC50 (binding) | = 2.9 uM | Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat single mutant (Gln55His) enzyme using malachite green assay | ChEMBL. | 12190310 |
IC50 (binding) | = 2.9 uM | Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat single mutant (Gln55His) enzyme using malachite green assay | ChEMBL. | 12190310 |
IC50 (binding) | > 10 uM | Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat single mutant (Gln50Lys) enzyme using malachite green assay | ChEMBL. | 12190310 |
IC50 (binding) | > 10 uM | Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat wild type enzyme using malachite green assay | ChEMBL. | 12190310 |
IC50 (binding) | > 10 uM | Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat single mutant (Gln50Lys) enzyme using malachite green assay | ChEMBL. | 12190310 |
IC50 (binding) | > 10 uM | Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat wild type enzyme using malachite green assay | ChEMBL. | 12190310 |
Inhibition (binding) | = 96 % | In vitro inhibition against epidermal growth factor receptor (EGFR) tyrosine kinase. | ChEMBL. | 12190310 |
Inhibition (binding) | = 96 % | In vitro inhibition against epidermal growth factor receptor (EGFR) tyrosine kinase. | ChEMBL. | 12190310 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.