Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Sus scrofa | Aminopeptidase N | References | |
Homo sapiens | alanyl (membrane) aminopeptidase | References | |
Sus scrofa | Cytosol aminopeptidase | References | |
Homo sapiens | endoplasmic reticulum aminopeptidase 2 | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | leucyl aminopeptidase | 0.0204 | 0.0163 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0246 | 0.3516 | 0.5422 |
Plasmodium falciparum | M17 leucyl aminopeptidase | 0.0204 | 0.0163 | 0.5 |
Mycobacterium leprae | Probable cytosol aminopeptidase PepB | 0.0204 | 0.0163 | 0.5 |
Trypanosoma cruzi | cytosolic leucyl aminopeptidase, putative | 0.0204 | 0.0163 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | leucyl aminopeptidase | 0.0204 | 0.0163 | 0.5 |
Onchocerca volvulus | 0.0328 | 1 | 0.5 | |
Echinococcus granulosus | aminopeptidase N | 0.0328 | 1 | 1 |
Mycobacterium tuberculosis | Probable aminopeptidase PepB | 0.0204 | 0.0163 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 0.6484 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.0328 | 1 | 1 |
Chlamydia trachomatis | cytosol aminopeptidase | 0.0204 | 0.0163 | 0.5 |
Leishmania major | cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 | 0.0204 | 0.0163 | 0.5 |
Plasmodium vivax | M17 leucyl aminopeptidase, putative | 0.0204 | 0.0163 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, Clan MF, Family M17, putative | 0.0204 | 0.0163 | 0.5 |
Toxoplasma gondii | leucyl aminopeptidase LAP | 0.0204 | 0.0163 | 0.5 |
Trypanosoma brucei | metallo-peptidase, Clan MF, Family M17 | 0.0204 | 0.0163 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.065 uM | Inhibition of recombinant human alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition measured for 15 mins by spectrofluorimetric analysis | ChEMBL. | 27100031 |
Ki (binding) | = 0.723 uM | Inhibition of pig kidney alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition measured for 15 mins by spectrofluorimetric analysis | ChEMBL. | 27100031 |
Ki (binding) | = 1.68 uM | Inhibition of human ERAP2 preincubated for 30 to 60 mins followed by addition of Arg-AMC as substrate measured for 15 mins by spectrofluorimetric method | ChEMBL. | 27390066 |
Ki (binding) | = 19.5 uM | Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition measured for 15 mins by spectrofluorimetric analysis | ChEMBL. | 27100031 |
Ki (binding) | > 250 uM | Inhibition of human ERAP1 preincubated for 30 to 60 mins followed by addition of Leu-AMC as substrate measured for 15 mins by spectrofluorimetric method | ChEMBL. | 27390066 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.