TDR Targets

Basic information

Technical information

TDR Targets ID: 21854
Name: N-[(6-amino-2-methylpyridin-3-yl)methyl]-2-[6 -methyl-2-oxo-3-(phenethylamino)pyrazin-1-yl] acetamide
MW: 406.481 | Formula: C22H26N6O2
H donors: 3 H acceptors: 3 LogP: 1.44 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Cn1c(C)cnc(c1=O)NCCc1ccccc1)NCc1ccc(nc1C)N
InChi: 1S/C22H26N6O2/c1-15-12-26-21(24-11-10-17-6-4-3-5-7-17)22(30)28(15)14-20(29)25-13-18-8-9-19(23)27-16(18)2/h3-9,12H,10-11,13-14H2,1-2H3,(H2,23,27)(H,24,26)(H,25,29)
InChiKey: PVDHYBJORRALSQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[(6-amino-2-methyl-3-pyridyl)methyl]-2-[6-methyl-2-oxo-3-(phenethylamino)pyrazin-1-yl]acetamide
N-[(6-amino-2-methyl-3-pyridyl)methyl]-2-[6-methyl-2-oxo-3-(phenethylamino)-1-pyrazinyl]acetamide
N-[(6-azanyl-2-methyl-pyridin-3-yl)methyl]-2-[6-methyl-2-oxo-3-(phenethylamino)pyrazin-1-yl]ethanamide
N-[(6-amino-2-methyl-3-pyridyl)methyl]-2-[2-keto-6-methyl-3-(phenethylamino)pyrazin-1-yl]acetamide
N-[(6-amino-2-methylpyridin-3-yl)methyl]-2-[6-methyl-2-oxo-3-(2-phenylethylamino)pyrazin-1-yl]acetamide
N-[(6-amino-2-methyl-3-pyridyl)methyl]-2-[6-methyl-2-oxo-3-(2-phenylethylamino)pyrazin-1-yl]acetamide
N-[(6-amino-2-methyl-3-pyridyl)methyl]-2-[6-methyl-2-oxo-3-(2-phenylethylamino)-1-pyrazinyl]acetamide
N-[(6-amino-2-methyl-3-pyridyl)methyl]-2-[2-keto-6-methyl-3-(2-phenylethylamino)pyrazin-1-yl]acetamide
N-[(6-amino-2-methyl-pyridin-3-yl)methyl]-2-[6-methyl-2-oxo-3-(2-phenylethylamino)pyrazin-1-yl]ethanamide
3-(2-Phenethylamino)-6-methyl-1-(2-amino-6-methyl-5-methylene-carboxamidomethyl-pyridinyl)pyrazinone

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	coagulation factor II (thrombin)	Starlite/ChEMBL	References
Homo sapiens	protease, serine, 3	Starlite/ChEMBL	References
Homo sapiens	protease, serine, 2 (trypsin 2)		References
Homo sapiens	protease, serine, 1 (trypsin 1)		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus		Get druggable targets OG5_126639	All targets in OG5_126639
Onchocerca volvulus		Get druggable targets OG5_126639	All targets in OG5_126639
Schistosoma japonicum	ko:K09639 transmembrane protease, serine 8, putative	Get druggable targets OG5_126639	All targets in OG5_126639
Schistosoma japonicum	ko:K09639 transmembrane protease, serine 8, putative	Get druggable targets OG5_126639	All targets in OG5_126639
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	Get druggable targets OG5_126639	All targets in OG5_126639
Brugia malayi	Trypsin family protein	Get druggable targets OG5_126639	All targets in OG5_126639
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	Get druggable targets OG5_126639	All targets in OG5_126639
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126639	All targets in OG5_126639
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126639	All targets in OG5_126639

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	cercarial elastase (S01 family)	protease, serine, 2 (trypsin 2)	247 aa	240 aa	25.8 %
Schistosoma mansoni	cercarial elastase (S01 family)	protease, serine, 3	261 aa	234 aa	25.2 %
Brugia malayi	Trypsin family protein	protease, serine, 1 (trypsin 1)	247 aa	287 aa	21.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0152	0.0135	0.4037
Mycobacterium ulcerans	carbon monoxide dehydrogenase	0.0126	0.0108	0.0104
Echinococcus granulosus	glycoprotein Antigen 5	0.0025	0.0004	0.0059
Onchocerca volvulus		0.0177	0.0161	0.4823
Schistosoma mansoni	cercarial elastase (S01 family)	0.0025	0.0004	0.0059
Loa Loa (eye worm)	trypsin family protein	0.0025	0.0004	0.0122
Leishmania major	hypothetical protein, conserved	0.0021	0	0.5
Treponema pallidum	quinoline 2-oxidoreductase	0.003	0.0009	0.8682
Schistosoma mansoni	cercarial elastase (S01 family)	0.0025	0.0004	0.0059
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0025	0.0004	0.0059
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0021	0	0.5
Brugia malayi	Trypsin family protein	0.0344	0.0334	1
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0025	0.0004	0.0122
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0025	0.0004	0.0059
Onchocerca volvulus		0.0025	0.0004	0.0122
Schistosoma mansoni	hypothetical protein	0.0025	0.0004	0.0059
Toxoplasma gondii	transporter, solute:sodium symporter (SSS) family protein	0.0177	0.0161	1
Echinococcus granulosus	high affinity choline transporter 1	0.0177	0.0161	0.2316
Echinococcus multilocularis	enteropeptidase	0.0025	0.0004	0.0059
Mycobacterium ulcerans	aerobic-type carbon monoxide dehydrogenase subunit CoxM_2	0.0064	0.0044	0.004
Loa Loa (eye worm)	hypothetical protein	0.0344	0.0334	1
Echinococcus multilocularis	solute carrier family 5	0.0694	0.0697	1
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0025	0.0004	0.0059
Mycobacterium ulcerans	carbon monoxyde dehydrogenase small chain CoxS	0.0036	0.0015	0.0011
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0025	0.0004	0.0059
Schistosoma mansoni	hypothetical protein	0.0025	0.0004	0.0059
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0344	0.0334	0.4802
Trichomonas vaginalis	xanthine dehydrogenase, putative	0.019	0.0174	0.5
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0025	0.0004	0.0059
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0025	0.0004	0.0059
Mycobacterium ulcerans	carbon monoxyde dehydrogenase small chain CoxS	0.0036	0.0015	0.0011
Schistosoma mansoni	cercarial elastase (S01 family)	0.0025	0.0004	0.0059
Mycobacterium tuberculosis	Probable carbon monoxyde dehydrogenase (large chain)	0.009	0.0071	0.0055
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0025	0.0004	0.0059
Trichomonas vaginalis	xanthine dehydrogenase, putative	0.019	0.0174	0.5
Echinococcus granulosus	enteropeptidase	0.0025	0.0004	0.0059
Plasmodium falciparum	cysteine repeat modular protein 1	0.0021	0	0.5
Mycobacterium tuberculosis	Probable carbon monoxyde dehydrogenase (medium chain)	0.0064	0.0044	0.0029
Schistosoma mansoni	cercarial elastase (S01 family)	0.0025	0.0004	0.0059
Schistosoma mansoni	inositol transporter	0.0694	0.0697	1
Echinococcus multilocularis	high affinity choline transporter 1	0.0177	0.0161	0.2316
Schistosoma mansoni	cercarial elastase (S01 family)	0.0025	0.0004	0.0059
Echinococcus granulosus	sodium:myo inositol cotransporter	0.0694	0.0697	1
Brugia malayi	Trypsin-like protease protein 5	0.0025	0.0004	0.0122
Schistosoma mansoni	cercarial elastase (S01 family)	0.0025	0.0004	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0004	0.0122
Schistosoma mansoni	cercarial elastase (S01 family)	0.0025	0.0004	0.0059
Echinococcus granulosus	solute carrier family 5	0.0694	0.0697	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0025	0.0004	0.0059
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.0177	0.0161	0.2316
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.0177	0.0161	0.2316
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0025	0.0004	0.0059
Mycobacterium ulcerans	histidinol dehydrogenase	0.9681	1	1
Echinococcus multilocularis	transmembrane protease serine 3	0.0025	0.0004	0.0059
Mycobacterium ulcerans	carbon monoxyde dehydrogenase medium chain CoxM	0.0064	0.0044	0.004
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0344	0.0334	0.4802
Onchocerca volvulus		0.0025	0.0004	0.0122
Onchocerca volvulus		0.0025	0.0004	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0004	0.0122
Brugia malayi	Trypsin family protein	0.0025	0.0004	0.0122
Brugia malayi	GH02984p	0.0177	0.0161	0.4823
Treponema pallidum	hypothetical protein	0.0031	0.001	1
Loa Loa (eye worm)	hypothetical protein	0.0344	0.0334	1
Schistosoma mansoni	sodium/solute symporter	0.0177	0.0161	0.2316
Schistosoma mansoni	cercarial elastase (S01 family)	0.0025	0.0004	0.0059
Trichomonas vaginalis	aldehyde oxidase, putative	0.019	0.0174	0.5
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0161	0.4823
Onchocerca volvulus		0.0025	0.0004	0.0122
Echinococcus granulosus	Mastin	0.0025	0.0004	0.0059
Brugia malayi	Trypsin family protein	0.0025	0.0004	0.0122
Schistosoma mansoni	cercarial elastase (S01 family)	0.0025	0.0004	0.0059
Onchocerca volvulus		0.0025	0.0004	0.0122
Schistosoma mansoni	cercarial elastase (S01 family)	0.0025	0.0004	0.0059
Mycobacterium ulcerans	hypothetical protein	0.0031	0.001	0.0006
Mycobacterium ulcerans	aerobic-type carbon monoxide dehydrogenase subunit CoxL_2	0.009	0.0071	0.0067
Echinococcus granulosus	sodium:glucose cotransporter	0.0694	0.0697	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0004	0.0122
Brugia malayi	hypothetical protein	0.0025	0.0004	0.0122
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0025	0.0004	0.0059
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0025	0.0004	0.0059
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.0694	0.0697	1
Onchocerca volvulus		0.0319	0.0308	0.9219
Echinococcus granulosus	sodium:glucose cotransporter 2	0.0694	0.0697	1
Schistosoma mansoni	inositol transporter	0.0694	0.0697	1
Echinococcus granulosus	transmembrane protease serine 3	0.0025	0.0004	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0161	0.4823
Brugia malayi	Sodium:solute symporter family protein	0.0177	0.0161	0.4823
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0004	0.0122
Mycobacterium tuberculosis	Probable histidinol dehydrogenase HisD (HDH)	0.9681	1	1
Mycobacterium ulcerans	carbon monoxyde dehydrogenase large chain CoxL	0.0056	0.0036	0.0032
Echinococcus multilocularis	Mastin	0.0025	0.0004	0.0059
Echinococcus multilocularis	glycoprotein Antigen 5	0.0025	0.0004	0.0059
Brugia malayi	hypothetical protein	0.0152	0.0135	0.4037
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0	0.5
Onchocerca volvulus		0.0344	0.0334	1
Onchocerca volvulus		0.0152	0.0135	0.4037
Mycobacterium ulcerans	carbon monoxyde dehydrogenase large chain CoxL	0.009	0.0071	0.0067
Brugia malayi	Trypsin family protein	0.0025	0.0004	0.0122
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.0694	0.0697	1
Schistosoma mansoni	high-affinity choline transporter	0.0177	0.0161	0.2316
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0004	0.0122

Activities

Activity type	Activity value	Assay description	Source	Reference
2x APTT (functional)	= 380 nM	in vitro anticoagulant potency (2x APTT) against rat plasma.	ChEMBL.	9804686
2x APTT (functional)	= 410 nM	in vitro anticoagulant potency (2x APTT) against Human plasma.	ChEMBL.	9804686
2x APTT (functional)	= 410 nM	in vitro anticoagulant potency (2x APTT) against Human plasma.	ChEMBL.	9804686
2x aPTT (functional)	= 0.41 uM	Concentration required to double the activated partial thromboplastin time (2x APTT) in human plasma	ChEMBL.	12570369
2x APTT (functional)	= 0.41 uM	Concentration needed to double the activated partial thromboplastin time in human plasma	ChEMBL.	14505652
2x APTT (functional)	= 0.41 uM	Concentration needed to double the activated partial thromboplastin time in human plasma	ChEMBL.	14505652
AUC (ADMET)	= 275 ug min ml-1	In vivo area under curve was calculated by peroral administration at 1 mg/kg in fasted dog	ChEMBL.	11934589
AUC (ADMET)	= 23.1 uM h	Area under curve was determined in dog after oral administration at 1 mg/kg	ChEMBL.	12617893
AUC (ADMET)	= 11.2 uM hr	Area under curve(AUC) value of the compoundin dogs at 0.5 mg/kg dose upon oral administration	ChEMBL.	9804686
Cmax (ADMET)	= 0.9 ug ml-1	In vivo maximal concentration was calculated at 1 mg/kg in dog	ChEMBL.	11934589
Cmax (ADMET)	= 1.96 uM	Maximum plasma concentration of the compound in dogs at 0.5 mg/kg dose upon oral administration	ChEMBL.	9804686
Cmax (ADMET)	= 5.37 uM	Cmax of the compound was determined in dog after oral administration at 1 mg/kg	ChEMBL.	12617893
Concentration (functional)	= 0.41 uM	In vitro concentration of the compound required to double the human activated partial thromboplastin time (2x APTT)	ChEMBL.	12617893
Concentration (functional)	= 0.41 uM	Concentration required to double the human activated partial thromboplastin time in human plasma	ChEMBL.	12482415
Concentration (functional)	= 0.41 uM	Concentration required to double the human activated partial thromboplastin time in human plasma	ChEMBL.	12482415
F (ADMET)	= 42 %	Oral bioavailability of compound in rat	ChEMBL.	15163182
F (ADMET)	= 60 %	Oral bioavailability of compound in rhesus macaques	ChEMBL.	15163182
F (ADMET)	= 91 %	Oral bioavailability in dog	ChEMBL.	15163182
Final plasma concentration (ADMET)	= 238 nM	Final plasma concentration after intravenous infusion at 5 microgram/Kg/min dose	ChEMBL.	9804686
Final plasma concentration (ADMET)	= 445 nM	Final plasma concentration after intravenous infusion	ChEMBL.	9804686
IC50 (binding)	= 0.8 nM	Inhibition of thrombin (unknown origin)	LITERATURE.	No reference
IC50 (binding)	= 1800 nM	Inhibition of trypsin (unknown origin)	ChEMBL.	No reference
Ki (binding)	= nM	In vitro inhibitory constant against factor Xa (FXa).	ChEMBL.	11934589
Ki (binding)	nM	In vitro inhibitory constant against trypsin; Inactive	ChEMBL.	11934589
Ki (binding)	= 0 nM	In vitro inhibitory constant against factor Xa (FXa).	ChEMBL.	11934589
Ki (binding)	0 nM	In vitro inhibitory constant against trypsin; Inactive	ChEMBL.	11934589
Ki (binding)	= 0.8 nM	Inhibitory activity of the compound against thrombin (IIa) was determined	ChEMBL.	9804686
Ki (binding)	= 0.8 nM	Inhibition of Thrombin	ChEMBL.	12617893
Ki (binding)	= 0.8 nM	Inhibition of thrombin in human plasma	ChEMBL.	12482415
Ki (binding)	= 0.8 nM	Inhibitory constant against thrombin (IIa)	ChEMBL.	12570369
Ki (binding)	= 0.8 nM	Inhibitory potency against human thrombin	ChEMBL.	15163182
Ki (binding)	= 0.8 nM	Inhibitory constant evaluated against thrombin (Factor IIa)	ChEMBL.	14505652
Ki (binding)	= 0.8 nM	Inhibitory activity of the compound against thrombin (IIa) was determined	ChEMBL.	9804686
Ki (binding)	= 0.8 nM	Inhibition of Thrombin	ChEMBL.	12617893
Ki (binding)	= 0.8 nM	Inhibition of thrombin in human plasma	ChEMBL.	12482415
Ki (binding)	= 0.8 nM	Inhibitory constant against thrombin (IIa)	ChEMBL.	12570369
Ki (binding)	= 0.8 nM	Inhibitory potency against human thrombin	ChEMBL.	15163182
Ki (binding)	= 0.8 nM	Inhibitory constant evaluated against thrombin (Factor IIa)	ChEMBL.	14505652
Ki (binding)	= 0.8 nM	Inhibition of Thrombin (unknown origin)	ChEMBL.	26200936
Ki (binding)	= 1 nM	In vitro inhibitory constant against human thrombin (FIIa).	ChEMBL.	11934589
Ki (binding)	= 1 nM	In vitro inhibitory constant against human thrombin (FIIa).	ChEMBL.	11934589
Ki (binding)	= 1800 nM	Inhibitory activity of the compound against trypsin was determined	ChEMBL.	9804686
Ki (binding)	= 1800 nM	Inhibition of Trypsin	ChEMBL.	12617893
Ki (binding)	= 1800 nM	Inhibition of trypsin in human plasma	ChEMBL.	12482415
Ki (binding)	= 1800 nM	Inhibitory constant against human trypsin	ChEMBL.	12570369
Ki (binding)	= 1800 nM	Inhibitory constant evaluated against trypsin	ChEMBL.	14505652
Ki (binding)	= 1800 nM	Inhibitory activity of the compound against trypsin was determined	ChEMBL.	9804686
Ki (binding)	= 1800 nM	Inhibition of Trypsin	ChEMBL.	12617893
Ki (binding)	= 1800 nM	Inhibition of trypsin in human plasma	ChEMBL.	12482415
Ki (binding)	= 1800 nM	Inhibitory constant against human trypsin	ChEMBL.	12570369
Ki (binding)	= 1800 nM	Inhibitory constant evaluated against trypsin	ChEMBL.	14505652
Ki (binding)	= 1 ug nM-1	In vitro inhibitory activity against human Thrombin (FIIa) cleavage of the chromogenic substrate	ChEMBL.	12270176
Occlusions (functional)	= 0	In vivo antithrombotic activity was measured after intravenous infusion (at 10 microgram/Kg/min) of the compound in rat FeCl3 arterial thrombosis model; 0/6	ChEMBL.	9804686
Occlusions (functional)	= 4	In vivo antithrombotic activity was measured after intravenous infusion (at 5 microgram/Kg/min) of the compound in rat FeCl3 arterial thrombosis model; 4/6	ChEMBL.	9804686
Selectivity ratio (binding)	= 1908	Ratio of inhibitory constant evaluated against trypsin to that of thrombin (Factor IIa)	ChEMBL.	14505652
Selectivity ratio (binding)	= 1908	Ratio of inhibitory constant evaluated against trypsin to that of thrombin (Factor IIa)	ChEMBL.	14505652
T max (ADMET)	= 52.5 min	time required for maximum concentration of the compound in dogs at 0.5 mg/kg dose upon oral administration	ChEMBL.	9804686
T1/2 (ADMET)	= 3.18 hr	Half-life of the compound was determined in dog after oral administration at 1 mg/kg	ChEMBL.	12617893
T1/2 (ADMET)	= 199 min	In vivo half life period was calculated at 1 mg/kg in dog	ChEMBL.	11934589
T1/2 (ADMET)	= 231 min	Half-life of the compound in dogs at 0.5 mg/kg dose upon oral administration	ChEMBL.	9804686
Unbound (functional)	= 6 %	Protein binding affinity of the compound was tested in human plasma, expressed as percent unbound (free)	ChEMBL.	12482415
Unbound (functional)	= 6 %	Protein binding affinity of the compound was tested in human plasma, expressed as percent unbound (free)	ChEMBL.	12482415

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL19080
PubChem: 154118

Bibliographic References

9 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 21854