Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0886 | 0.2914 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0209 | 0.0686 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0194 | 0.1091 | 0.3587 |
Echinococcus granulosus | neuroendocrine convertase 2 | 0.0274 | 0.1735 | 0.5135 |
Brugia malayi | hypothetical protein | 0.0085 | 0.0209 | 0.0686 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0194 | 0.1091 | 0.0904 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0085 | 0.0209 | 0.0686 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0194 | 0.1091 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.1091 | 0.3587 |
Echinococcus granulosus | proprotein convertase subtilisin:kexin type 5 | 0.0265 | 0.1662 | 0.4865 |
Brugia malayi | proprotein convertase 2 | 0.0274 | 0.1735 | 0.5705 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0085 | 0.0209 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0905 | 0.2975 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0085 | 0.0209 | 0.0686 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0085 | 0.0209 | 0.0003 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0085 | 0.0209 | 0.0686 |
Loa Loa (eye worm) | hypothetical protein | 0.0435 | 0.3041 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0473 | 0.3342 | 0.3202 |
Plasmodium falciparum | plasmepsin I | 0.0194 | 0.1091 | 1 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0085 | 0.0209 | 0.0686 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0204 | 0.1173 | 0.4075 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0194 | 0.1091 | 0.6076 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0204 | 0.1173 | 0.0988 |
Onchocerca volvulus | CoRest homolog | 0.0168 | 0.0886 | 0.6136 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0103 | 0.0356 | 0.1032 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0085 | 0.0209 | 0.0003 |
Plasmodium falciparum | plasmepsin IV | 0.0194 | 0.1091 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0085 | 0.0209 | 0.0003 |
Onchocerca volvulus | 0.0221 | 0.1313 | 1 | |
Giardia lamblia | High cysteine membrane protein Group 2 | 0.0162 | 0.0832 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0085 | 0.0209 | 0.0003 |
Loa Loa (eye worm) | proprotein convertase 2 | 0.0103 | 0.0356 | 0.1171 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.1173 | 0.3858 |
Brugia malayi | neuroendocrine convertase 1 precursor | 0.0274 | 0.1735 | 0.5705 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0194 | 0.1091 | 0.2736 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.0274 | 0.1735 | 0.6877 |
Brugia malayi | SWIRM domain containing protein | 0.0221 | 0.1313 | 0.4316 |
Schistosoma mansoni | furin-1 (S08 family) | 0.0189 | 0.1055 | 0.0867 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.1313 | 0.4316 |
Schistosoma mansoni | subfamily S8B non-peptidase homologue (S08 family) | 0.0103 | 0.0356 | 0.0153 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0194 | 0.1091 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0103 | 0.0356 | 0.1032 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0209 | 0.0686 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0103 | 0.0356 | 0.1032 |
Brugia malayi | endoprotease bli-4 precursor | 0.0435 | 0.3041 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.1173 | 0.3858 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0103 | 0.0356 | 0.1032 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0265 | 0.1662 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0103 | 0.0356 | 0.1032 |
Echinococcus multilocularis | 0.0351 | 0.2361 | 1 | |
Echinococcus multilocularis | proprotein convertase subtilisin:kexin type 5 | 0.0265 | 0.1662 | 0.6515 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0103 | 0.0356 | 0.1032 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0194 | 0.1091 | 0.3664 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0265 | 0.1662 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0085 | 0.0209 | 0.0003 |
Echinococcus granulosus | furin | 0.0435 | 0.3041 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0473 | 0.3342 | 0.3202 |
Brugia malayi | celfurPC protein | 0.0351 | 0.2361 | 0.7764 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0085 | 0.0209 | 0.0686 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0085 | 0.0209 | 0.0003 |
Plasmodium vivax | plasmepsin IV, putative | 0.0194 | 0.1091 | 1 |
Brugia malayi | Pepsin A precursor | 0.0085 | 0.0209 | 0.0686 |
Brugia malayi | hypothetical protein | 0.0085 | 0.0209 | 0.0686 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.0847 | 0.2787 |
Plasmodium falciparum | plasmepsin VI | 0.0194 | 0.1091 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0204 | 0.1173 | 0.3043 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0435 | 0.3041 | 0.2895 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0194 | 0.1091 | 1 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.0164 | 0.0847 | 0.2787 |
Loa Loa (eye worm) | endoprotease bli-4 | 0.0435 | 0.3041 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0085 | 0.0209 | 0.0003 |
Plasmodium falciparum | plasmepsin II | 0.0194 | 0.1091 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 4.6 uM | In vitro inhibitory concentration that relaxes KCL induced contraction in rat detrusor strips by 50% | ChEMBL. | 10737752 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.