Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0787 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0787 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0787 | 1 | 1 |
Onchocerca volvulus | 0.0787 | 1 | 1 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0772 | 0.9593 | 0.9593 |
Plasmodium vivax | vivapain-2 | 0.0787 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0787 | 1 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0787 | 1 | 1 |
Onchocerca volvulus | 0.0787 | 1 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0787 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0787 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0787 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0787 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0787 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0787 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0533 | 0.3182 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0787 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0787 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0787 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0533 | 0.3182 | 0.3182 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0772 | 0.9593 | 0.9593 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0787 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0787 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0787 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0787 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0772 | 0.9593 | 0.9593 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0787 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0772 | 0.9593 | 0.9593 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0787 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0787 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0787 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0772 | 0.9593 | 0.9593 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0787 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0787 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0787 | 1 | 1 |
Onchocerca volvulus | 0.0787 | 1 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0787 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0533 | 0.3182 | 0.3182 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0787 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0787 | 1 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0787 | 1 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0787 | 1 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0772 | 0.9593 | 0.9593 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0533 | 0.3182 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0787 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0787 | 1 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0787 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0787 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0787 | 1 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0772 | 0.9593 | 0.9593 |
Onchocerca volvulus | Cathepsin L homolog | 0.0787 | 1 | 1 |
Onchocerca volvulus | 0.0787 | 1 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0787 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0787 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0787 | 1 | 1 |
Onchocerca volvulus | 0.0787 | 1 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0787 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0787 | 1 | 1 |
Onchocerca volvulus | 0.0787 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0787 | 1 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0533 | 0.3182 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0787 | 1 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0787 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0787 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0787 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0787 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0787 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0787 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0787 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0787 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0787 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0787 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0787 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0787 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0772 | 0.9593 | 0.9593 |
Loa Loa (eye worm) | cysteine protease | 0.0787 | 1 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0787 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0772 | 0.9593 | 0.9403 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0787 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0787 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0533 | 0.3182 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0787 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0772 | 0.9593 | 0.9593 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0787 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0787 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0787 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0787 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0787 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0787 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0787 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0787 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0787 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0533 | 0.3182 | 0.3182 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0787 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0787 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0787 | 1 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0787 | 1 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0533 | 0.3182 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0787 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0787 | 1 | 0.5 |
Entamoeba histolytica | cysteine protease, putative | 0.0787 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0787 | 1 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0787 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0533 | 0.3182 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0787 | 1 | 1 |
Onchocerca volvulus | 0.0787 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0787 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0787 | 1 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0533 | 0.3182 | 0.3182 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0787 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0787 | 1 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0787 | 1 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0772 | 0.9593 | 0.9593 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Antibacterial activity (functional) | = 0.2 | In vitro antibacterial activity against Escherichia coli NIHJ JC-2. | ChEMBL. | 11814802 |
Antibacterial activity (functional) | < 0.025 | In vitro antibacterial activity against Staphylococcus aureus 209P JC-1. | ChEMBL. | 11814802 |
Antibacterial activity (functional) | = 0.2 | In vitro antibacterial activity against Escherichia coli NIHJ JC-2. | ChEMBL. | 11814802 |
Antibacterial activity (functional) | = 0.39 | In vitro antibacterial activity against Ps. auruginosa 26. | ChEMBL. | 11814802 |
Antibacterial activity (functional) | = 1.56 | In vitro antibacterial activity against Proteus vulgaris IAM 1025. | ChEMBL. | 11814802 |
Antibacterial activity (functional) | = 12.5 | In vitro antibacterial activity against Staphylococcus aureus 3004 Methicillin-resistant S. aureus. | ChEMBL. | 11814802 |
Recovery (ADMET) | = 50 % | Tested for urinary recovery in mice after subcutaneous administration of 20 mg/Kg | ChEMBL. | 11814802 |
Recovery (ADMET) | = 50 % | Tested for urinary recovery in mice after subcutaneous administration of 20 mg/Kg | ChEMBL. | 11814802 |
Stability (functional) | = 0.084 | Tested for stability of compound to swine renal DHP-1 relative to imipenem (IMP) | ChEMBL. | 11814802 |
Stability (functional) | = 0.28 | Compound stability against human renal DHP-1 relative to imipenem (IMP) | ChEMBL. | 11814802 |
Stability (functional) | = 0.084 | Tested for stability of compound to swine renal DHP-1 relative to imipenem (IMP) | ChEMBL. | 11814802 |
Stability (functional) | = 0.28 | Compound stability against human renal DHP-1 relative to imipenem (IMP) | ChEMBL. | 11814802 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.