Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kelch-like ECH-associated protein 1 | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Kelch motif family protein | kelch-like ECH-associated protein 1 | 624 aa | 565 aa | 31.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0001 | 0.0000037143 | 0.013 |
Echinococcus multilocularis | kelch protein 10 | 0.0001 | 0.0003 | 0.0003 |
Brugia malayi | BTB/POZ domain containing protein | 0.0001 | 0.0000037143 | 0.013 |
Onchocerca volvulus | 0.0001 | 0.0000037143 | 1 | |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0001 | 0.0003 | 1 |
Brugia malayi | hypothetical protein | 0.0001 | 0.0000037143 | 0.013 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0000037143 | 0.0000037143 |
Brugia malayi | Kelch motif family protein | 0.0001 | 0.0003 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0229 | 1 | 1 |
Echinococcus granulosus | kelch protein 18 | 0.0001 | 0.0003 | 0.0003 |
Brugia malayi | Btbd7 protein | 0.0001 | 0.0000037143 | 0.013 |
Echinococcus multilocularis | kelch protein 18 | 0.0001 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0.0001 | 0.0000037143 | 1 | |
Onchocerca volvulus | 0.0001 | 0.0000037143 | 1 | |
Brugia malayi | hypothetical protein | 0.0001 | 0.0000037143 | 0.013 |
Echinococcus granulosus | kelch ECH associated protein 1 | 0.0228 | 0.9972 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0001 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0003 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0003 | 0.0003 |
Brugia malayi | BTB/POZ domain containing protein | 0.0001 | 0.0003 | 1 |
Schistosoma mansoni | btb/poz domain containing protein | 0.0001 | 0.0000037143 | 0.0000037143 |
Loa Loa (eye worm) | Btbd6 protein | 0.0001 | 0.0000037143 | 0.013 |
Loa Loa (eye worm) | Klhl5 protein | 0.0001 | 0.0003 | 1 |
Trichomonas vaginalis | ankyrin repeat-containing protein, putative | 0.0001 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0001 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0003 | 0.0003 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0001 | 0 | 0.5 |
Loa Loa (eye worm) | ring canal kelch protein | 0.0001 | 0.0003 | 1 |
Brugia malayi | Kelch motif family protein | 0.0001 | 0.0003 | 1 |
Echinococcus granulosus | kelch protein 10 | 0.0001 | 0.0003 | 0.0003 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0228 | 0.9972 | 0.9972 |
Brugia malayi | Armadillo/beta-catenin-like repeat family protein | 0.0001 | 0.0000037143 | 0.013 |
Echinococcus granulosus | kelch protein 12 | 0.0001 | 0.0003 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0003 | 0.0003 |
Brugia malayi | BTB/POZ domain containing protein 2 | 0.0001 | 0.0000037143 | 0.013 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | BTB/POZ domain-containing protein 9 | 0.0001 | 0.0000037143 | 0.013 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0001 | 0 | 0.5 |
Echinococcus multilocularis | ectoderm neural cortex protein 1 | 0.0001 | 0.0003 | 0.0003 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0228 | 0.9972 | 0.9972 |
Brugia malayi | BTB/POZ domain containing protein | 0.0001 | 0.0000037143 | 0.013 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0228 | 0.9972 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0001 | 0.0000037143 | 0.013 |
Echinococcus granulosus | ectoderm neural cortex protein 1 | 0.0001 | 0.0003 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0003 | 0.0003 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0228 | 0.9972 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0001 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0001 | 0.0000037143 | 0.013 |
Brugia malayi | hypothetical protein | 0.0001 | 0.0000037143 | 0.013 |
Trichomonas vaginalis | ankyrin repeat domain protein, putative | 0.0001 | 0 | 0.5 |
Loa Loa (eye worm) | BTB/POZ domain-containing protein 2 | 0.0001 | 0.0000037143 | 0.013 |
Brugia malayi | BTB/POZ domain containing protein 9 | 0.0001 | 0.0000037143 | 0.013 |
Trichomonas vaginalis | multiple ankyrin repeats single kh domain protein, putative | 0.0001 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0001 | 0 | 0.5 |
Echinococcus multilocularis | kelch protein 12 | 0.0001 | 0.0003 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0001 | 0.0000037143 | 0.013 |
Brugia malayi | Kelch-like protein X | 0.0001 | 0.0003 | 1 |
Echinococcus granulosus | kelch protein 3 | 0.0001 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0.0001 | 0.0000037143 | 1 | |
Brugia malayi | BTB/POZ domain containing protein | 0.0001 | 0.0000037143 | 0.013 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0001 | 0.0000037143 | 0.013 |
Echinococcus multilocularis | kelch protein 3 | 0.0001 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | Btbd7 protein | 0.0001 | 0.0000037143 | 0.013 |
Loa Loa (eye worm) | hypothetical protein | 0.0001 | 0.0000037143 | 0.013 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.2 uM | Inhibition of human Keap1 kelch domain (Ala321 to Thr609 residues) binding to fluorescent labeled Nrf2 peptide preincubated for 15 mins followed by Nrf2 peptide addition measured after 30 mins by fluorescence polarization assay | ChEMBL. | 27437072 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.