Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sodium channel, voltage-gated, type I, alpha subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0229 | 0.3638 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0229 | 0.3638 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0124 | 0.1694 | 0.4655 |
Plasmodium falciparum | carbonic anhydrase | 0.0124 | 0.1694 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.022 | 0.3471 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0124 | 0.1694 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0124 | 0.1694 | 0.1694 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0116 | 0.1536 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0068 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.1694 | 0.4655 |
Leishmania major | ribonuclease H1, putative | 0.0116 | 0.1536 | 0.1515 |
Leishmania major | carbonic anhydrase-like protein | 0.0229 | 0.3638 | 0.3964 |
Brugia malayi | RNase H family protein | 0.0116 | 0.1536 | 0.4222 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0289 | 0.4744 | 1 |
Trypanosoma brucei | unspecified product | 0.0128 | 0.1776 | 0.0284 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0229 | 0.3638 | 0.2483 |
Echinococcus granulosus | carbonic anhydrase | 0.0124 | 0.1694 | 0.4655 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0229 | 0.3638 | 0.3638 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0229 | 0.3638 | 1 |
Brugia malayi | RNase H family protein | 0.0116 | 0.1536 | 0.4222 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0068 | 0.0068 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0509 | 0.8818 | 1 |
Echinococcus granulosus | ribonuclease H1 | 0.0116 | 0.1536 | 0.4222 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0229 | 0.3638 | 0.3638 |
Schistosoma mansoni | phosphoglucomutase | 0.0116 | 0.1536 | 0.1536 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0509 | 0.8818 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0128 | 0.1776 | 0.0284 |
Echinococcus multilocularis | carbonic anhydrase | 0.0124 | 0.1694 | 0.4655 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0509 | 0.8818 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0124 | 0.1694 | 0.1694 |
Schistosoma mansoni | phosphoglucomutase | 0.0116 | 0.1536 | 0.1536 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0068 | 0.0187 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0124 | 0.1694 | 0.4655 |
Echinococcus granulosus | carbonic anhydrase | 0.0124 | 0.1694 | 0.4655 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0378 | 0.104 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0509 | 0.8818 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.1694 | 0.4655 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0124 | 0.1694 | 0.4655 |
Schistosoma mansoni | phosphoglucomutase | 0.0116 | 0.1536 | 0.1536 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0124 | 0.1694 | 0.1694 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.1694 | 0.4655 |
Echinococcus multilocularis | carbonic anhydrase | 0.0124 | 0.1694 | 0.4655 |
Giardia lamblia | Ribonuclease H | 0.0116 | 0.1536 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.0229 | 0.3638 | 1 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0128 | 0.1776 | 0.0284 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0229 | 0.3638 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0124 | 0.1694 | 0.4655 |
Echinococcus granulosus | sodium channel protein | 0.0045 | 0.0236 | 0.0648 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0378 | 0.104 |
Brugia malayi | RNase H family protein | 0.0116 | 0.1536 | 0.4222 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.1694 | 0.1694 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0116 | 0.1536 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0378 | 0.104 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0229 | 0.3638 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0509 | 0.8818 | 0.8818 |
Echinococcus multilocularis | ribonuclease H1 | 0.0116 | 0.1536 | 0.4222 |
Echinococcus multilocularis | sodium channel protein | 0.0045 | 0.0236 | 0.0648 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0124 | 0.1694 | 0.4655 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0128 | 0.1776 | 0.0284 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0124 | 0.1694 | 0.4655 |
Trichomonas vaginalis | conserved hypothetical protein | 0.022 | 0.3471 | 1 |
Schistosoma mansoni | amine GPCR | 0.0184 | 0.2798 | 0.2798 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0116 | 0.1536 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0124 | 0.1694 | 0.4655 |
Trypanosoma brucei | RNA helicase, putative | 0.0573 | 1 | 1 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0128 | 0.1776 | 0.0284 |
Schistosoma mansoni | carbonic anhydrase | 0.0124 | 0.1694 | 0.1694 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0229 | 0.3638 | 1 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0045 | 0.0236 | 0.0648 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0229 | 0.3638 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0124 | 0.1694 | 0.4655 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0378 | 0.104 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7 uM | Inhibition of binding of Batrachotoxinin [3H]-BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex | ChEMBL. | 2579237 |
IC50 (binding) | = 7 uM | Inhibition of binding of Batrachotoxinin [3H]-BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex | ChEMBL. | 2579237 |
Inhibition (binding) | = 54.9 % | Inhibition of binding of Batrachotoxinin [3H]-BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex at 10 microM | ChEMBL. | 2579237 |
Inhibition (binding) | = 54.9 % | Inhibition of binding of Batrachotoxinin [3H]-BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex at 10 microM | ChEMBL. | 2579237 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.