TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 457.192 | Formula: C25H31NO5S
H donors: 3 H acceptors: 4 LogP: 4.55 Rotable bonds: 4
Rule of 5 violations (Lipinski): 0
SMILES: Oc1ccc(cc1)C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCc2c1ccc(c2)OS(=O)(=O)N
InChi: InChI=1S/C25H31NO5S/c1-24-12-10-21-20-9-7-19(31-32(26,29)30)14-17(20)4-8-22(21)23(24)11-13-25(24,28)15-16-2-5-18(27)6-3-16/h2-3,5-7,9,14,21-23,27-28H,4,8,10-13,15H2,1H3,(H2,26,29,30)/t21-,22-,23+,24+,25-/m1/s1
InChiKey: VXGJGAFRYDZTOG-WJGLBBAVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	steroid sulfatase (microsomal), isozyme S		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	hypothetical protein	Get druggable targets OG5_130476	All targets in OG5_130476

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium ulcerans	arylsulfatase AtsB	steroid sulfatase (microsomal), isozyme S	583 aa	470 aa	23.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Aminotransferase class III	0.0044	0.0691	0.9863
Brugia malayi	follicle stimulating hormone receptor	0.0045	0.07	0.0684
Echinococcus granulosus	neuropeptide s receptor	0.0045	0.07	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0045	0.07	1
Echinococcus granulosus	orexin receptor type 2	0.0045	0.07	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0693	0.989
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0045	0.07	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0045	0.07	1
Brugia malayi	G-protein coupled receptor	0.0045	0.07	0.0684
Mycobacterium ulcerans	acetylornithine aminotransferase	0.0044	0.0691	0.091
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0045	0.07	1
Brugia malayi	larval opioid receptor	0.0045	0.07	0.0684
Echinococcus multilocularis	fmrfamide receptor	0.0045	0.07	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.07	1
Loa Loa (eye worm)	TYRA-2 protein	0.0045	0.07	0.0684
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0045	0.07	1
Brugia malayi	GnHR receptor homolog	0.0045	0.07	0.0684
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0045	0.07	1
Brugia malayi	Serotonin receptor	0.0045	0.07	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0693	0.989
Echinococcus granulosus	serotonin receptor	0.0045	0.07	1
Echinococcus granulosus	neuropeptide Y receptor	0.0045	0.07	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0045	0.07	1
Schistosoma mansoni	histamine h1 receptor	0.0045	0.07	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0045	0.07	0.0684
Loa Loa (eye worm)	G-protein coupled receptor	0.0045	0.07	0.0684
Schistosoma mansoni	neuropeptide receptor	0.0045	0.07	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0045	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0693	0.989
Brugia malayi	hypothetical protein	0.0045	0.07	0.0684
Schistosoma mansoni	hypothetical protein	0.0045	0.07	1
Echinococcus granulosus	neuropeptide receptor	0.0045	0.07	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0045	0.07	1
Brugia malayi	Dopamine receptor protein 1	0.0045	0.07	0.0684
Echinococcus multilocularis	neuropeptides capa receptor	0.0045	0.07	1
Echinococcus granulosus	voltage gated potassium channel	0.0012	0.0018	0.0258
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0045	0.07	0.0684
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0041	0.062	0.8849
Brugia malayi	hypothetical protein	0.0045	0.07	0.0684
Echinococcus multilocularis	neuropeptides capa receptor	0.0045	0.07	1
Wolbachia endosymbiont of Brugia malayi	acetylornithine transaminase protein	0.0044	0.0691	0.5
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0045	0.07	1
Echinococcus multilocularis	sex peptide receptor	0.0045	0.07	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0045	0.07	0.0684
Leishmania major	hypothetical protein, conserved	0.0025	0.028	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0045	0.07	1
Schistosoma mansoni	voltage-gated potassium channel	0.0012	0.0018	0.0258
Brugia malayi	putative neuropeptide receptor NPR1	0.0045	0.07	0.0684
Mycobacterium ulcerans	adenosylmethionine-8-amino-7-oxononanoate aminotransferase	0.0312	0.6232	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.07	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0045	0.07	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0045	0.07	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0045	0.07	1
Schistosoma mansoni	hypothetical protein	0.0045	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Brugia malayi	hypothetical protein	0.0045	0.07	0.0684
Schistosoma mansoni	amine GPCR	0.0045	0.07	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0045	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0044	0.0691	0.091
Schistosoma mansoni	opsin-like receptor	0.0045	0.07	1
Brugia malayi	putative neuropeptide receptor	0.0045	0.07	0.0684
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0045	0.07	0.0684
Brugia malayi	Cytochrome P450 family protein	0.0018	0.0136	0.0119
Echinococcus multilocularis	voltage gated potassium channel	0.0012	0.0018	0.0258
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.07	1
Echinococcus granulosus	g protein coupled receptor	0.0045	0.07	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0045	0.07	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0045	0.07	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.07	1
Trichomonas vaginalis	acetylornithine aminotransferase, putative	0.0312	0.6232	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0041	0.062	0.0603
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0045	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Brugia malayi	hypothetical protein	0.0045	0.07	0.0684
Schistosoma mansoni	amine GPCR	0.0045	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Echinococcus multilocularis	ornithine aminotransferase	0.0044	0.0691	0.9863
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0045	0.07	1
Echinococcus multilocularis	Aminotransferase class III	0.0044	0.0691	0.9863
Schistosoma mansoni	neuropeptide receptor	0.0045	0.07	1
Plasmodium falciparum	ornithine aminotransferase	0.0044	0.0691	1
Echinococcus granulosus	g protein coupled receptor	0.0045	0.07	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0045	0.07	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0025	0.028	0.0262
Schistosoma mansoni	growth hormone secretagogue receptor	0.0045	0.07	1
Brugia malayi	Dopamine receptor protein 2	0.0045	0.07	0.0684
Echinococcus granulosus	tm gpcr rhodopsin	0.0045	0.07	1
Schistosoma mansoni	amine GPCR	0.0045	0.07	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0045	0.07	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0045	0.07	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.07	1
Brugia malayi	hypothetical protein	0.0045	0.07	0.0684
Echinococcus granulosus	sex peptide receptor	0.0045	0.07	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.07	1
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.0698	0.996
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0045	0.07	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0045	0.07	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Mycobacterium ulcerans	glutamate-1-semialdehyde aminotransferase	0.0044	0.0691	0.091
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Brugia malayi	hypothetical protein	0.0045	0.07	0.0684
Schistosoma mansoni	neuropeptide f receptor 76f	0.0045	0.07	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0045	0.07	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0693	0.989
Echinococcus multilocularis	ornithine aminotransferase	0.0044	0.0691	0.9863
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Brugia malayi	neuropeptide F receptor	0.0045	0.07	0.0684
Brugia malayi	hypothetical protein	0.0016	0.01	0.0082
Loa Loa (eye worm)	neuropeptide F receptor	0.0045	0.07	0.0684
Echinococcus multilocularis	somatostatin receptor	0.0045	0.07	1
Echinococcus multilocularis	allatostatin A receptor	0.0045	0.07	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0045	0.07	0.0684
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.07	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0045	0.07	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0041	0.062	0.0603
Brugia malayi	Cytochrome P450 family protein	0.0018	0.0136	0.0119
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0693	0.989
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0045	0.07	1
Brugia malayi	RE15519p	0.0045	0.07	0.0684
Brugia malayi	4-aminobutyrate aminotransferase, mitochondrial precursor	0.0044	0.0691	0.0674
Loa Loa (eye worm)	neuropeptide F receptor	0.0045	0.07	0.0684
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0693	0.0676
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0045	0.07	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0045	0.07	1
Echinococcus granulosus	G protein coupled receptor 139	0.0045	0.07	1
Mycobacterium ulcerans	hypothetical protein	0.0312	0.6232	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0045	0.07	0.0684
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0045	0.07	1
Brugia malayi	hypothetical protein	0.0045	0.07	0.0684
Brugia malayi	G protein-coupled receptor F59B2.13	0.0045	0.07	0.0684
Echinococcus granulosus	ornithine aminotransferase	0.0044	0.0691	0.9863
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0045	0.07	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0045	0.07	1
Onchocerca volvulus		0.0495	1	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.07	1
Brugia malayi	Dopamine receptor	0.0045	0.07	0.0684
Brugia malayi	Melatonin receptor type 1A	0.0045	0.07	0.0684
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0693	0.989
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0012	0.0018	0.0258
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.07	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0045	0.07	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0045	0.07	1
Brugia malayi	hypothetical protein	0.0025	0.028	0.0262
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0045	0.07	1
Mycobacterium ulcerans	ornithine aminotransferase RocD1 and RocD2	0.0044	0.0691	0.091
Echinococcus granulosus	tm gpcr rhodopsin	0.0045	0.07	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0045	0.07	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0045	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Echinococcus granulosus	allatostatin A receptor	0.0045	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Mycobacterium tuberculosis	Probable aminotransferase	0.0312	0.6232	1
Schistosoma mansoni	biogenic amine receptor	0.0045	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Echinococcus multilocularis	g protein coupled receptor	0.0045	0.07	1
Echinococcus granulosus	neuropeptides capa receptor	0.0045	0.07	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0045	0.07	0.0684
Echinococcus granulosus	fmrfamide receptor	0.0045	0.07	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0045	0.07	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0045	0.07	1
Echinococcus granulosus	g-protein coupled receptor	0.0045	0.07	1
Echinococcus multilocularis	neuropeptide receptor	0.0045	0.07	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.07	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0045	0.07	1
Brugia malayi	neuropeptide F receptor	0.0045	0.07	0.0684
Echinococcus multilocularis	G protein coupled receptor 139	0.0045	0.07	1
Echinococcus multilocularis	g-protein coupled receptor	0.0045	0.07	1
Schistosoma mansoni	neuropeptide receptor	0.0045	0.07	1
Brugia malayi	AKH receptor	0.0045	0.07	0.0684
Schistosoma mansoni	biogenic amine receptor	0.0045	0.07	1
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0044	0.0691	0.091
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.07	1
Echinococcus granulosus	neuropeptide receptor A26	0.0045	0.07	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0045	0.07	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0018	0.0136	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0045	0.07	1
Mycobacterium tuberculosis	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA	0.0312	0.6232	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0045	0.07	0.0684
Echinococcus multilocularis	orexin receptor type 2	0.0045	0.07	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0045	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0147	0.2812	0.2799
Schistosoma mansoni	hypothetical protein	0.0045	0.07	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0045	0.07	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.07	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.07	1
Brugia malayi	Serotonin receptor	0.0045	0.07	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Brugia malayi	sulfakinin receptor protein	0.0045	0.07	0.0684
Toxoplasma gondii	ornithine aminotransferase, mitochondrial precursor, putative	0.0044	0.0691	1
Brugia malayi	ORL1-like opioid receptor	0.0045	0.07	0.0684
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.028	1
Echinococcus multilocularis	fmrfamide receptor	0.0045	0.07	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0045	0.07	1
Schistosoma mansoni	opsin-like receptor	0.0045	0.07	1
Echinococcus multilocularis	neuropeptide receptor	0.0045	0.07	1
Mycobacterium leprae	PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA	0.0312	0.6232	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0045	0.07	0.0684
Schistosoma mansoni	ornithine--oxo-acid transaminase	0.0044	0.0691	0.9863
Schistosoma mansoni	myosin xvIII	0.0045	0.07	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0045	0.07	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Echinococcus granulosus	hypothetical protein	0.0045	0.07	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0018	0.0136	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Echinococcus granulosus	somatostatin receptor	0.0045	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Echinococcus granulosus	neuropeptide receptor	0.0045	0.07	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0045	0.07	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0045	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Schistosoma mansoni	adenoreceptor	0.0045	0.07	1
Schistosoma mansoni	neuropeptide receptor	0.0045	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Schistosoma mansoni	amine GPCR	0.0045	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Echinococcus granulosus	neuropeptides capa receptor	0.0045	0.07	1
Brugia malayi	hypothetical protein	0.0045	0.07	0.0684
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0045	0.07	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0045	0.07	0.0684
Brugia malayi	hypothetical protein	0.0045	0.07	0.0684
Chlamydia trachomatis	glutamate-1-semialdehyde-2,1-aminomutase	0.0044	0.0691	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0045	0.07	1
Brugia malayi	G protein-coupled receptor	0.0045	0.07	0.0684
Echinococcus granulosus	neuropeptide Y receptor	0.0045	0.07	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0045	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Echinococcus multilocularis	g protein coupled receptor	0.0045	0.07	1
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.0698	0.996
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.028	1
Echinococcus multilocularis	g protein coupled receptor	0.0045	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.028	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.07	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0045	0.07	0.0684
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0693	0.0676
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0045	0.07	1
Brugia malayi	G-protein coupled receptor	0.0045	0.07	0.0684
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0045	0.07	1
Schistosoma mansoni	amine GPCR	0.0045	0.07	1
Schistosoma mansoni	biogenic amine receptor	0.0045	0.07	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0693	0.989
Schistosoma mansoni	voltage-gated potassium channel	0.0012	0.0018	0.0258
Echinococcus multilocularis	serotonin receptor	0.0045	0.07	1
Echinococcus multilocularis	serotonin receptor	0.0045	0.07	1
Schistosoma mansoni	hypothetical protein	0.0045	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0045	0.07	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0045	0.07	1
Plasmodium vivax	ornithine aminotransferase, putative	0.0044	0.0691	1
Mycobacterium ulcerans	L-lysine aminotransferase	0.0044	0.0691	0.091
Loa Loa (eye worm)	pax transcription factor protein 2	0.0495	1	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0041	0.062	0.8849
Echinococcus granulosus	7tm_1 domain containing protein	0.0045	0.07	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0012	0.0018	0.0258
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.07	1
Echinococcus granulosus	g protein coupled receptor	0.0045	0.07	1
Brugia malayi	hypothetical protein	0.0045	0.07	0.0684
Schistosoma mansoni	opsin-like receptor	0.0045	0.07	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.07	1
Brugia malayi	hypothetical protein	0.0347	0.6952	0.6947
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.07	0.0684
Loa Loa (eye worm)	CYP4Cod1	0.0018	0.0136	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0508	0.0491
Echinococcus multilocularis	neuropeptide s receptor	0.0045	0.07	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.03 uM	Inhibition of estrone sulfatase in human JEG-3 cells using [3H]-estrone sulphate as substrate incubated for 1 hr by liquid scintillation counting method	ChEMBL.	26974384

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3806088

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 2202280