Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | aspartyl protease ASP1 | 0.0163 | 0.0625 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.0625 | 0.1533 |
Echinococcus multilocularis | Furin 1 | 0.0173 | 0.0685 | 0.0229 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0163 | 0.0625 | 0.045 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0349 | 0.1754 | 0.16 |
Plasmodium vivax | plasmepsin IV, putative | 0.0163 | 0.0625 | 1 |
Echinococcus multilocularis | 0.0591 | 0.3219 | 1 | |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0209 | 0.0903 | 0.0733 |
Schistosoma mansoni | furin-1 (S08 family) | 0.0318 | 0.1568 | 0.1411 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0209 | 0.0903 | 0.0804 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.046 | 0.2427 | 0.6948 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0163 | 0.0625 | 0.1533 |
Giardia lamblia | High cysteine membrane protein Group 2 | 0.0272 | 0.1286 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.0681 | 0.1671 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0173 | 0.0685 | 0.1032 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0209 | 0.0903 | 0.107 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0732 | 0.4078 | 0.3968 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0163 | 0.0625 | 1 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.009 | 0.0183 | 0.0448 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0173 | 0.0685 | 0.1032 |
Echinococcus granulosus | Furin 1 | 0.0173 | 0.0685 | 0.0172 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.009 | 0.0183 | 0.0448 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0173 | 0.0685 | 0.1032 |
Brugia malayi | endoprotease bli-4 precursor | 0.0732 | 0.4078 | 1 |
Plasmodium falciparum | plasmepsin II | 0.0163 | 0.0625 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0349 | 0.1754 | 0.16 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0173 | 0.0685 | 0.1032 |
Brugia malayi | proprotein convertase 2 | 0.046 | 0.2427 | 0.5952 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0445 | 0.2336 | 1 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0163 | 0.0625 | 1 |
Loa Loa (eye worm) | endoprotease bli-4 | 0.0732 | 0.4078 | 1 |
Echinococcus granulosus | neuroendocrine convertase 2 | 0.046 | 0.2427 | 0.5219 |
Schistosoma mansoni | hypothetical protein | 0.0142 | 0.0495 | 0.0318 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.009 | 0.0183 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0732 | 0.4078 | 1 |
Loa Loa (eye worm) | proprotein convertase 2 | 0.0173 | 0.0685 | 0.1679 |
Brugia malayi | Pepsin A precursor | 0.009 | 0.0183 | 0.0448 |
Echinococcus granulosus | proprotein convertase subtilisin:kexin type 5 | 0.0445 | 0.2336 | 0.4953 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.0903 | 0.2213 |
Echinococcus multilocularis | proprotein convertase subtilisin:kexin type 5 | 0.0445 | 0.2336 | 0.6595 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0173 | 0.0685 | 0.1032 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.009 | 0.0183 | 0.0448 |
Plasmodium falciparum | plasmepsin VI | 0.0163 | 0.0625 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0173 | 0.0685 | 0.1032 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0163 | 0.0625 | 0.0709 |
Onchocerca volvulus | CoRest homolog | 0.0172 | 0.0681 | 0.6028 |
Brugia malayi | SWIRM domain containing protein | 0.0227 | 0.101 | 0.2476 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.0168 | 0.0652 | 0.1598 |
Onchocerca volvulus | 0.0227 | 0.101 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.0903 | 0.2213 |
Brugia malayi | hypothetical protein | 0.009 | 0.0183 | 0.0448 |
Echinococcus granulosus | furin | 0.0732 | 0.4078 | 1 |
Schistosoma mansoni | subfamily S8B non-peptidase homologue (S08 family) | 0.0173 | 0.0685 | 0.0511 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.101 | 0.2476 |
Plasmodium falciparum | plasmepsin IV | 0.0163 | 0.0625 | 1 |
Brugia malayi | neuroendocrine convertase 1 precursor | 0.046 | 0.2427 | 0.5952 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 0.1378 | 0.3379 |
Plasmodium falciparum | plasmepsin I | 0.0163 | 0.0625 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0183 | 0.0448 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.009 | 0.0183 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0183 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0652 | 0.1598 |
Brugia malayi | hypothetical protein | 0.009 | 0.0183 | 0.0448 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0445 | 0.2336 | 1 |
Brugia malayi | celfurPC protein | 0.0591 | 0.3219 | 0.7893 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED30 (functional) | = 3.6 mg kg-1 | Antiinflammatory activity assessed by inhibition of carrageenan-induced edema in rats at a dose of 15 mg/kg | ChEMBL. | 2724294 |
ED50 (functional) | = 6 mg kg-1 | Analgesic activity of the compound was assessed from the ability of the compound to inhibit phenylquinone-induced writhing in mouse at a dose of 70 mg/kg | ChEMBL. | 2724294 |
ED50 (functional) | = 6 mg kg-1 | Analgesic activity of the compound was assessed from the ability of the compound to inhibit phenylquinone-induced writhing in mouse at a dose of 70 mg/kg | ChEMBL. | 2724294 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.