Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Cholesteryl ester transfer protein | Starlite/ChEMBL | References |
Homo sapiens | cholesteryl ester transfer protein, plasma | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.5 uM | Concentration required for 50% inhibition of cholesteryl ester transfer protein in presence of buffer. | ChEMBL. | 12190312 |
IC50 (binding) | = 1.5 uM | Inhibition of CETP | ChEMBL. | 17604633 |
IC50 (binding) | = 1.5 uM | Concentration required for 50% inhibition of cholesteryl ester transfer protein in presence of buffer. | ChEMBL. | 12190312 |
IC50 (binding) | = 1.5 uM | Inhibition of CETP | ChEMBL. | 17604633 |
IC50 (binding) | = 1.5 uM | Inhibition of CETP in rabbit serum after 1 hr by fluorescent cholesteryl esters transfer assay | ChEMBL. | 20116902 |
IC50 (binding) | = 46 uM | Concentration required for 50% Inhibition against Cholesteryl ester transfer protein in presence of human serum | ChEMBL. | 12190312 |
IC50 (binding) | = 46 uM | Concentration required for 50% Inhibition against Cholesteryl ester transfer protein in presence of human serum | ChEMBL. | 12190312 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.