Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin E2 | Starlite/ChEMBL | References |
Homo sapiens | cyclin B3 | Starlite/ChEMBL | References |
Homo sapiens | cyclin B2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | cyclin B, putative | 0.0094 | 0.0145 | 1 |
Trichomonas vaginalis | cyclin A, putative | 0.0094 | 0.0145 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0873 | 0.2619 | 1 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0094 | 0.0145 | 0.0371 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0873 | 0.2619 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0094 | 0.0145 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0094 | 0.0145 | 1 |
Schistosoma mansoni | cyclin B3 | 0.0199 | 0.0476 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.2323 | 0.7226 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0094 | 0.0145 | 1 |
Schistosoma mansoni | cyclin B | 0.0094 | 0.0145 | 0.2232 |
Trichomonas vaginalis | cyclin B, putative | 0.0094 | 0.0145 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0094 | 0.0145 | 1 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0199 | 0.0476 | 1 |
Entamoeba histolytica | cyclin, putative | 0.0094 | 0.0145 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0094 | 0.0145 | 1 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0199 | 0.0476 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0873 | 0.2619 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0094 | 0.0145 | 1 |
Echinococcus multilocularis | cyclin B | 0.0094 | 0.0145 | 0.2232 |
Echinococcus granulosus | cyclin B | 0.0094 | 0.0145 | 0.2232 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0199 | 0.0476 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0873 | 0.2619 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0873 | 0.2619 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0873 | 0.2619 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0873 | 0.2619 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0199 | 0.0476 | 0.0468 |
Giardia lamblia | Telomerase catalytic subunit | 0.0873 | 0.2619 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.14 uM | Inhibitory activity against baculovirus expressed Cyclin dependent kinase 2-cyclinE | ChEMBL. | 12190313 |
IC50 (binding) | = 0.14 uM | Inhibitory activity against baculovirus expressed Cyclin dependent kinase 1-cyclinB | ChEMBL. | 12190313 |
IC50 (binding) | = 0.14 uM | Inhibitory activity against baculovirus expressed Cyclin dependent kinase 2-cyclinE | ChEMBL. | 12190313 |
IC50 (binding) | = 0.14 uM | Inhibitory activity against baculovirus expressed Cyclin dependent kinase 1-cyclinB | ChEMBL. | 12190313 |
IC50 (binding) | > 25 uM | Inhibitory activity against baculovirus expressed Cyclin dependent kinase 4-cyclinD1 | ChEMBL. | 12190313 |
IC50 (binding) | > 25 uM | Inhibitory activity against baculovirus expressed Cyclin dependent kinase 4-cyclinD1 | ChEMBL. | 12190313 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.