Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 5 (sodium/glucose cotransporter), member 2 | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transient receptor potential cation channel subfamily A member | 0.0177 | 0.9478 | 0.97 |
Schistosoma mansoni | inositol transporter | 0.0181 | 0.9771 | 1 |
Echinococcus granulosus | solute carrier family 5 | 0.0181 | 0.9771 | 0.9771 |
Echinococcus multilocularis | ankyrin repeat protein | 0.0177 | 0.9478 | 0.9478 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0076 | 0.2121 | 1 |
Onchocerca volvulus | 0.0046 | 0 | 0.5 | |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0185 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.2121 | 1 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0181 | 0.9771 | 0.9771 |
Echinococcus granulosus | carboxylesterase 5A | 0.0076 | 0.2121 | 0.2121 |
Echinococcus granulosus | acetylcholinesterase | 0.0076 | 0.2121 | 0.2121 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0181 | 0.9771 | 0.9771 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0181 | 0.9771 | 0.9771 |
Echinococcus multilocularis | acetylcholinesterase | 0.0076 | 0.2121 | 0.2121 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.2121 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0076 | 0.2121 | 0.2121 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0181 | 0.9771 | 0.9771 |
Brugia malayi | Carboxylesterase family protein | 0.0076 | 0.2121 | 1 |
Echinococcus granulosus | ankyrin repeat protein | 0.0177 | 0.9478 | 0.9478 |
Echinococcus multilocularis | acetylcholinesterase | 0.0076 | 0.2121 | 0.2121 |
Echinococcus granulosus | acetylcholinesterase | 0.0076 | 0.2121 | 0.2121 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0046 | 0 | 0.5 |
Schistosoma mansoni | inositol transporter | 0.0181 | 0.9771 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0076 | 0.2121 | 0.2171 |
Loa Loa (eye worm) | carboxylesterase | 0.0076 | 0.2121 | 1 |
Echinococcus multilocularis | solute carrier family 5 | 0.0181 | 0.9771 | 0.9771 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.0181 | 0.9771 | 0.9771 |
Brugia malayi | Carboxylesterase family protein | 0.0076 | 0.2121 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 14 nM | Inhibition Assay | BINDINGDB. | No reference |
IC50 (binding) | = 14 nM | Inhibition Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.