Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0448 | 0.0433 |
Leishmania major | pentamidine resistance protein 1 | 0.0078 | 0.0448 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 5, putative | 0.0078 | 0.0448 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0078 | 0.0448 | 0.5 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0078 | 0.0448 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 2, putative | 0.0078 | 0.0448 | 0.5 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0078 | 0.0448 | 1 |
Giardia lamblia | ABC transporter, putative | 0.0078 | 0.0448 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0078 | 0.0448 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.0078 | 0.0448 | 1 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.0078 | 0.0448 | 1 |
Trypanosoma brucei | p-glycoprotein | 0.0078 | 0.0448 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0078 | 0.0448 | 0.5 |
Leishmania major | ABC-thiol transporter | 0.0078 | 0.0448 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0433 | 0.0418 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.0078 | 0.0448 | 0.0433 |
Schistosoma mansoni | multidrug resistance protein | 0.0078 | 0.0448 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.0078 | 0.0448 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0078 | 0.0448 | 0.5 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.0078 | 0.0448 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0078 | 0.0448 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0448 | 0.0433 |
Trypanosoma brucei | multidrug resistance protein E | 0.0078 | 0.0448 | 0.5 |
Brugia malayi | multidrug resistance related protein 1 | 0.0078 | 0.0448 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0464 | 1 | 1 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.0078 | 0.0448 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0464 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0078 | 0.0448 | 0.5 |
Leishmania major | p-glycoprotein e | 0.0078 | 0.0448 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0078 | 0.0448 | 0.5 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.0078 | 0.0448 | 1 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0078 | 0.0448 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 6, putative | 0.0078 | 0.0448 | 0.5 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.0078 | 0.0448 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0464 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0464 | 1 | 1 |
Entamoeba histolytica | ABC transporter, putative | 0.0078 | 0.0448 | 0.5 |
Giardia lamblia | MRP-like ABC transporter | 0.0078 | 0.0448 | 1 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0078 | 0.0448 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0078 | 0.0448 | 0.5 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0078 | 0.0448 | 0.5 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0078 | 0.0448 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 1, putative | 0.0078 | 0.0448 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 0.3 uM | Antiproliferative activity against human ovarian OVCAR-3 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 0.3 uM | Antiproliferative activity against human ovarian OVCAR-3 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 0.51 uM | Antiproliferative activity against human colon HCT-116 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 0.51 uM | Antiproliferative activity against human colon HCT-116 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 0.54 uM | Antiproliferative activity against human CNS SF-539 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 0.54 uM | Antiproliferative activity against human CNS SF-539 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 0.6 uM | Antiproliferative activity against human breast MDA-MB-435 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 0.6 uM | Antiproliferative activity against human breast MDA-MB-435 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 1.13 uM | Antiproliferative activity against human melanoma UACC-62 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 1.13 uM | Antiproliferative activity against human melanoma UACC-62 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 1.8 uM | Antiproliferative activity against human lung HOP-62 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 1.8 uM | Antiproliferative activity against human lung HOP-62 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 1.97 uM | Antiproliferative activity against human prostate DU-145 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 1.97 uM | Antiproliferative activity against human prostate DU-145 cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 2.19 uM | Antiproliferative activity against human renal SN12C cancer cell line | ChEMBL. | 11689077 |
GI50 (functional) | = 2.19 uM | Antiproliferative activity against human renal SN12C cancer cell line | ChEMBL. | 11689077 |
MGM (functional) | = 0.695 uM | Mean graph midpoint value for cytotoxic activity against human cancer cell lines | ChEMBL. | 11689077 |
MGM (functional) | = 0.695 uM | Mean graph midpoint value for cytotoxic activity against human cancer cell lines | ChEMBL. | 11689077 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.