Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 13 | Starlite/ChEMBL | References |
Homo sapiens | mitogen-activated protein kinase 12 | References | |
Homo sapiens | mitogen-activated protein kinase 11 | References | |
Homo sapiens | mitogen-activated protein kinase 14 | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 14 | 360 aa | 336 aa | 33.3 % |
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 11 | 364 aa | 361 aa | 33.0 % |
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 12 | 357 aa | 362 aa | 30.1 % |
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 13 | 365 aa | 366 aa | 30.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | DNA polymerase I (polA) | 0.0054 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase I | 0.0054 | 0 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1065 | 0.2629 | 1 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0054 | 0 | 0.5 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.1065 | 0.2629 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0457 | 0.1046 | 1 |
Chlamydia trachomatis | DNA polymerase I | 0.0054 | 0 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0457 | 0.1046 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.2835 | 0.723 | 1 |
Schistosoma mansoni | hypothetical protein | 0.034 | 0.0743 | 0.5 |
Schistosoma mansoni | copper/topaquinone oxidase | 0.034 | 0.0743 | 0.5 |
Mycobacterium ulcerans | DNA polymerase I | 0.0054 | 0 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0457 | 0.1046 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0457 | 0.1046 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1065 | 0.2629 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0457 | 0.1046 | 1 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.0054 | 0 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0457 | 0.1046 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.1065 | 0.2629 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.1065 | 0.2629 | 0.5 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.1065 | 0.2629 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0457 | 0.1046 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.1065 | 0.2629 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.1065 | 0.2629 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change (functional) | = -43 % | In vivo inhibition of LPS-induced TNF production in mice 50 mg/Kg. | ChEMBL. | 8831759 |
Change (functional) | = -43 % | In vivo inhibition of LPS-induced TNF production in mice 50 mg/Kg. | ChEMBL. | 8831759 |
IC50 (binding) | = 0.07 uM | In vitro inhibitory concentration against radioligand [3H]-SB-202,190 binding to CSBP kinase in human monocytic cell line, THP-1 | ChEMBL. | 8831759 |
IC50 (binding) | = 0.07 uM | In vitro inhibitory concentration against radioligand [3H]-SB-202,190 binding to CSBP kinase in human monocytic cell line, THP-1 | ChEMBL. | 8831759 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.