TDR Targets

Basic information

Technical information

TDR Targets ID: 222280
Name: N-(2,4-dichloro-5-methoxyphenyl)-6,7-dimethox yquinazolin-4-amine
MW: 380.225 | Formula: C17H15Cl2N3O3
H donors: 1 H acceptors: 2 LogP: 4.59 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc2c(ncnc2cc1OC)Nc1cc(OC)c(cc1Cl)Cl
InChi: 1S/C17H15Cl2N3O3/c1-23-14-7-13(10(18)5-11(14)19)22-17-9-4-15(24-2)16(25-3)6-12(9)20-8-21-17/h4-8H,1-3H3,(H,20,21,22)
InChiKey: PRWLJVUZPGQTGF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2,4-dichloro-5-methoxy-phenyl)-6,7-dimethoxy-quinazolin-4-amine
N-(2,4-dichloro-5-methoxyphenyl)-6,7-dimethoxy-4-quinazolinamine
(2,4-dichloro-5-methoxy-phenyl)-(6,7-dimethoxyquinazolin-4-yl)amine
quinazoline deriv. 3b

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SRC proto-oncogene, non-receptor tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.0036	0.0312
Echinococcus granulosus	tyrosine protein kinase HCK	0.0036	0.0891	0.7806
Brugia malayi	Protein kinase domain containing protein	0.0006	0.0036	0.0049
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0006	0.0036	0.0312
Onchocerca volvulus		0.0006	0.0036	0.0036
Schistosoma mansoni	tyrosine kinase	0.0006	0.0036	0.0312
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0006	0.0036	0.0312
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0009	0.0124	0.1083
Onchocerca volvulus		0.0006	0.0036	0.0036
Brugia malayi	Protein kinase domain containing protein	0.0006	0.0036	0.0049
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0006	0.0036	0.04
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.004	0.0982	0.8605
Schistosoma mansoni	tyrosine kinase	0.0045	0.1142	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.001	0.0159	0.1395
Echinococcus granulosus	tyrosine protein kinase Src42A	0.004	0.0982	0.8605
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0045	0.1142	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0009	0.0124	0.1083
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.1142	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.001	0.0159	0.1395
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	0.1142	1
Brugia malayi	hypothetical protein	0.0006	0.0036	0.0049
Schistosoma mansoni	tyrosine kinase	0.0045	0.1142	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.0036	0.0312
Echinococcus multilocularis	tyrosine protein kinase shark	0.0006	0.0036	0.0312
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.0036	0.0312
Brugia malayi	protein-tyrosine kinase	0.0041	0.1018	0.1407
Echinococcus multilocularis	tyrosine kinase	0.0006	0.0036	0.0312
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.0036	0.0312
Trypanosoma brucei	telomerase reverse transcriptase	0.0099	0.2639	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0041	0.1018	0.8917
Echinococcus granulosus	growth factor receptor bound protein 2	0.0009	0.0124	0.1083
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.1142	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.0036	0.0312
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0041	0.1018	0.8917
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0041	0.1018	0.8917
Echinococcus granulosus	tyrosine kinase	0.0041	0.1018	0.8917
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0009	0.0124	0.1083
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.0036	0.0312
Schistosoma mansoni	adapter molecule crk	0.0009	0.0124	0.1083
Schistosoma mansoni	nck2/grb4	0.0009	0.0124	0.1083
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0036	0.0891	0.7806
Echinococcus granulosus	tyrosine protein kinase shark	0.0006	0.0036	0.0312
Echinococcus multilocularis	tyrosine protein kinase Abl	0.001	0.0159	0.1395
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0124	0.1083
Brugia malayi	Protein kinase domain containing protein	0.0006	0.0036	0.0049
Brugia malayi	Protein kinase domain containing protein	0.0006	0.0036	0.0049
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0045	0.1142	1
Schistosoma mansoni	tyrosine kinase	0.001	0.0159	0.1395
Schistosoma mansoni	tyrosine kinase	0.001	0.0159	0.1395
Loa Loa (eye worm)	TK protein kinase	0.0036	0.0891	0.7806
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0045	0.1142	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.0036	0.0312
Loa Loa (eye worm)	SRC-1	0.0045	0.1142	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0006	0.0036	0.0312
Echinococcus multilocularis	NCK adaptor protein	0.0009	0.0124	0.1083
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0045	0.1142	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0045	0.1142	1
Plasmodium vivax	telomerase reverse transcriptase, putative	0.0099	0.2639	0.5
Leishmania major	telomerase reverse transcriptase, putative	0.0099	0.2639	0.5
Giardia lamblia	Telomerase catalytic subunit	0.0099	0.2639	0.5
Schistosoma mansoni	tyrosine kinase	0.0006	0.0036	0.0312
Toxoplasma gondii	RNA-directed DNA polymerase	0.0099	0.2639	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0006	0.0036	0.0312
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0045	0.1142	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.0036	0.0312
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0045	0.1142	1
Brugia malayi	Variant SH3 domain containing protein	0.0009	0.0124	0.0171
Loa Loa (eye worm)	TK protein kinase	0.0041	0.1018	0.8917
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0045	0.1142	1
Echinococcus granulosus	c src tyrosine kinase	0.001	0.0159	0.1395
Echinococcus granulosus	tyrosine kinase	0.0006	0.0036	0.0312
Echinococcus granulosus	tyrosine protein kinase Blk	0.0041	0.1018	0.8917
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0045	0.1142	1
Brugia malayi	Sex muscle abnormal protein 5	0.0009	0.0124	0.0171
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	0.1142	1
Plasmodium falciparum	telomerase reverse transcriptase	0.0099	0.2639	0.5
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0099	0.2639	0.5
Brugia malayi	SRC-1	0.0045	0.1142	0.1578
Brugia malayi	Telomerase reverse transcriptase	0.0264	0.7234	1
Onchocerca volvulus		0.0006	0.0036	0.0036
Onchocerca volvulus		0.0006	0.0036	0.0036
Brugia malayi	Variant SH3 domain containing protein	0.0009	0.0124	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0036	0.0312
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0032	0.0284
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0009	0.0124	0.1083
Onchocerca volvulus		0.0006	0.0036	0.0036
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.1142	1
Onchocerca volvulus		0.0006	0.0036	0.0036
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.0036	0.0312
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0099	0.2639	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0041	0.1018	0.8917
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0045	0.1142	1
Echinococcus granulosus	NCK adaptor protein	0.0009	0.0124	0.1083
Entamoeba histolytica	protein kinase, putative	0.0036	0.0891	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	0.1142	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0009	0.0124	0.1083
Schistosoma mansoni	growth factor receptor-bound protein	0.0009	0.0124	0.1083
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0006	0.0036	0.0312
Echinococcus multilocularis	c src tyrosine kinase	0.001	0.0159	0.1395
Brugia malayi	SH2 domain containing protein	0.0006	0.0036	0.0049
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0006	0.0036	0.0312
Brugia malayi	Tyrosine-protein kinase abl-1	0.001	0.0159	0.022
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0045	0.1142	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.001	0.0159	0.1395
Brugia malayi	SH2 domain containing protein	0.0006	0.0036	0.0049
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.0036	0.0312
Brugia malayi	Protein kinase domain containing protein	0.0006	0.0036	0.0049

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 390 nM	Inhibition against Src kinase	ChEMBL.	11689083
IC50 (binding)	= 390 nM	Inhibition against Src kinase	ChEMBL.	11689083

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 5328928

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 222280