Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | fad oxidoreductase | 0.0131 | 0.0797 | 0.0794 |
Schistosoma mansoni | intermediate filament proteins | 0.0011 | 0.0034 | 0.0031 |
Trypanosoma brucei | FAD dependent oxidoreductase, putative | 0.0131 | 0.0797 | 0.5 |
Entamoeba histolytica | NAD(FAD)-dependent dehydrogenase, putative | 0.0131 | 0.0797 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0054 | 0.005 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0099 | 0.0592 | 0.0592 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.011 | 0.0665 | 1 |
Echinococcus granulosus | glycerol 3 phosphate dehydrogenase | 0.0131 | 0.0797 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0004 | 0.0004 |
Echinococcus granulosus | lamin | 0.0011 | 0.0034 | 0.0385 |
Brugia malayi | follicle stimulating hormone receptor | 0.0099 | 0.0592 | 0.7429 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.011 | 0.0665 | 1 |
Echinococcus multilocularis | FAD dependent oxidoreductase domain containing protein | 0.0131 | 0.0797 | 1 |
Schistosoma mansoni | glycerol-3-phosphate dehydrogenase | 0.0131 | 0.0797 | 0.0794 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.1567 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0131 | 0.0797 | 0.5 |
Leishmania major | glycerol-3-phosphate dehydrogenase-like protein | 0.0131 | 0.0797 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0011 | 0.0034 | 0.0385 |
Trypanosoma brucei | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0131 | 0.0797 | 0.5 |
Trypanosoma brucei | electron transfer flavoprotein-ubiquinone oxidoreductase, putative | 0.0131 | 0.0797 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0011 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0034 | 0.0034 |
Echinococcus granulosus | lamin dm0 | 0.0011 | 0.0034 | 0.0385 |
Onchocerca volvulus | Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog | 0.0131 | 0.0797 | 1 |
Chlamydia trachomatis | D-amino acid dehydrogenase | 0.0131 | 0.0797 | 0.5 |
Echinococcus multilocularis | glycerol 3 phosphate dehydrogenase | 0.0131 | 0.0797 | 1 |
Brugia malayi | RE18450p | 0.0131 | 0.0797 | 1 |
Brugia malayi | intermediate filament protein | 0.0011 | 0.0034 | 0.0428 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0011 | 0.0034 | 0.0034 |
Toxoplasma gondii | FAD-dependent glycerol-3-phosphate dehydrogenase | 0.0131 | 0.0797 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0011 | 0.0034 | 0.0428 |
Schistosoma mansoni | ATP:guanidino kinase (Smc74) | 0.0131 | 0.0797 | 0.0794 |
Trypanosoma brucei | glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial | 0.0131 | 0.0797 | 0.5 |
Schistosoma mansoni | d-amino acid oxidase | 0.1567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0097 | 0.0097 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0797 | 0.0797 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.1437 | 0.9163 | 1 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0131 | 0.0797 | 0.5 |
Loa Loa (eye worm) | glycerol-3-phosphate dehydrogenase | 0.0131 | 0.0797 | 0.0797 |
Brugia malayi | pyruvate dehydrogenase phosphatase regulatory subunit precursor | 0.0131 | 0.0797 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0072 | 0.0423 | 0.5092 |
Plasmodium falciparum | FAD-dependent glycerol-3-phosphate dehydrogenase, putative | 0.0131 | 0.0797 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0015 | 0.0054 | 0.0672 |
Brugia malayi | dimethylglycine dehydrogenase, mitochondrial precursor, putative | 0.0131 | 0.0797 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.011 | 0.0665 | 1 |
Entamoeba histolytica | anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative | 0.0131 | 0.0797 | 0.5 |
Trypanosoma brucei | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0131 | 0.0797 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0131 | 0.0797 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0007 | 0.0004 | 0.0045 |
Schistosoma mansoni | lamin | 0.0011 | 0.0034 | 0.0031 |
Schistosoma mansoni | fad oxidoreductase | 0.0131 | 0.0797 | 0.0794 |
Schistosoma mansoni | NAD dehydrogenase | 0.0131 | 0.0797 | 0.0794 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.011 | 0.0665 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.011 | 0.0665 | 0.834 |
Giardia lamblia | Glycerol-3-phosphate dehydrogenase | 0.0131 | 0.0797 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0033 | 0.0033 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.011 | 0.0665 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0007 | 0.0004 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0797 | 0.0797 |
Trypanosoma cruzi | FAD dependent oxidoreductase, putative | 0.0131 | 0.0797 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0021 | 0.0097 | 0.1211 |
Onchocerca volvulus | Dimethylglycine dehydrogenase, mitochondrial homolog | 0.0131 | 0.0797 | 1 |
Trypanosoma cruzi | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0131 | 0.0797 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0797 | 0.0797 |
Echinococcus multilocularis | lamin | 0.0011 | 0.0034 | 0.0385 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.011 | 0.0665 | 0.0665 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0021 | 0.0097 | 0.0097 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase, putative | 0.0131 | 0.0797 | 0.5 |
Echinococcus multilocularis | musashi | 0.0011 | 0.0034 | 0.0385 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.011 | 0.0665 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0131 | 0.0797 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0011 | 0.0034 | 0.0385 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.1567 | 1 | 1 |
Brugia malayi | cDNA sequence BC016226 | 0.0131 | 0.0797 | 1 |
Plasmodium vivax | FAD-dependent glycerol-3-phosphate dehydrogenase, putative | 0.0131 | 0.0797 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0054 | 0.0054 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 20 | 0.0131 | 0.0797 | 0.5 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0131 | 0.0797 | 0.5 |
Echinococcus granulosus | FAD dependent oxidoreductase domain containing protein | 0.0131 | 0.0797 | 1 |
Trypanosoma cruzi | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0131 | 0.0797 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0007 | 0.0004 | 0.0004 |
Onchocerca volvulus | Putative fad oxidoreductase | 0.0131 | 0.0797 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0021 | 0.0097 | 0.1211 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0076 | 0.0448 | 0.1027 |
Schistosoma mansoni | lamin | 0.0011 | 0.0034 | 0.0031 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0076 | 0.0448 | 0.1027 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 14 % | In vitro inhibitory activity against H1N9 strain of Influenza neuraminidase (membrane) at 7 mM concentration | ChEMBL. | 9406595 |
Inhibition (binding) | = 14 % | In vitro inhibitory activity against H1N9 strain of Influenza neuraminidase (membrane) at 7 mM concentration | ChEMBL. | 9406595 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.