Detailed information for compound 2242743

Basic information

Technical information
  • TDR Targets ID: 2242743
  • Name: ethyl 4-[(4-methoxyphenyl)-methylamino]quinaz oline-2-carboxylate
  • MW: 337.143 | Formula: C19H19N3O3
  • H donors: 0 H acceptors: 3 LogP: 4.08 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 0
  • SMILES: CCOC(=O)c1nc(N(c2ccc(cc2)OC)C)c2c(n1)cccc2
  • InChi: InChI=1S/C19H19N3O3/c1-4-25-19(23)17-20-16-8-6-5-7-15(16)18(21-17)22(2)13-9-11-14(24-3)12-10-13/h5-12H,4H2,1-3H3
  • InChiKey: OAKTULBXWVWETK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 4-[(4-methoxyphenyl)-methyl-amino]quinazoline-2-carboxylate
  • 4-[(4-methoxyphenyl)-methylamino]-2-quinazolinecarboxylic acid ethyl ester
  • 4-[(4-methoxyphenyl)-methyl-amino]quinazoline-2-carboxylic acid ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Kinesin motor domain containing protein 0.0053 0.0875 0.1919
Trichomonas vaginalis rotamase, putative 0.004 0.0544 0.0872
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0237 0.0275
Loa Loa (eye worm) kinesin-like protein KLP2 0.0053 0.0875 0.1919
Loa Loa (eye worm) hypothetical protein 0.0028 0.0237 0.052
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.052 1
Schistosoma mansoni hypothetical protein 0.0041 0.0565 0.0654
Schistosoma mansoni ap endonuclease 0.0023 0.0094 0.0108
Trichomonas vaginalis set domain proteins, putative 0.0225 0.5259 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.052 1
Trichomonas vaginalis rotamase, putative 0.0039 0.052 0.0825
Echinococcus multilocularis kinesin family 1 0.041 1 1
Schistosoma mansoni rotamase 0.004 0.0544 0.063
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0094 0.5
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0094 0.0205
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.052 1
Entamoeba histolytica kinesin, putative 0.0053 0.0875 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0028 0.0237 0.0237
Plasmodium vivax SET domain protein, putative 0.0028 0.0237 0.1835
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1052 0.2307
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0565 0.1239
Brugia malayi Pre-SET motif family protein 0.0028 0.0237 0.052
Schistosoma mansoni hypothetical protein 0.0205 0.4745 0.5493
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.052 1
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0544 0.1193
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0028 0.0237 0.0237
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0094 0.5
Plasmodium vivax kinesin-5 0.0053 0.0875 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0094 0.5
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0197 0.4561 1
Schistosoma mansoni kinesin eg-5 0.0053 0.0875 0.1013
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0028 0.0237 0.0275
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1052 0.2307
Onchocerca volvulus 0.0225 0.5259 1
Echinococcus granulosus geminin 0.0205 0.4745 0.4745
Schistosoma mansoni hypothetical protein 0.0357 0.8638 1
Schistosoma mansoni ap endonuclease 0.0023 0.0094 0.0108
Echinococcus multilocularis geminin 0.0205 0.4745 0.4745
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0094 0.0205
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.052 0.5454
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0237 0.0275
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0094 0.5
Loa Loa (eye worm) hypothetical protein 0.006 0.1052 0.2307
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.052 0.5454
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0094 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0544 0.0872
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1052 0.2307
Schistosoma mansoni hypothetical protein 0.0205 0.4745 0.5493
Loa Loa (eye worm) hypothetical protein 0.0041 0.0565 0.1239
Toxoplasma gondii kinesin motor domain-containing protein 0.0053 0.0875 1
Echinococcus multilocularis expressed protein 0.004 0.0544 0.0544
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.021 0.021
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0094 0.0094
Plasmodium falciparum kinesin-5 0.0053 0.0875 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0237 0.0275
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0544 0.1193
Brugia malayi Pre-SET motif family protein 0.0197 0.4561 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0028 0.0237 0.1835
Echinococcus granulosus expressed protein 0.004 0.0544 0.0544
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0028 0.0237 0.0237
Giardia lamblia Kinesin-5 0.0053 0.0875 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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