Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0717 | 0.3699 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0138 | 0.056 | 0.1514 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.1879 | 1 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0 | 0.5 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0292 | 0.1394 | 0.3768 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0717 | 0.3699 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.005 | 0.0083 | 0.0223 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0041 | 0.0034 | 0.0092 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0717 | 0.3699 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0292 | 0.1394 | 0.3768 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0222 | 0.1017 | 0.1017 |
Brugia malayi | beta-lactamase | 0.0035 | 0 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0041 | 0.0034 | 0.0092 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0041 | 0.0034 | 0.0092 |
Plasmodium falciparum | peptide deformylase | 0.1879 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0154 | 0.0645 | 0.0645 |
Toxoplasma gondii | hypothetical protein | 0.0047 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0154 | 0.0645 | 0.0645 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.1879 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0138 | 0.056 | 0.1514 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.1879 | 1 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0292 | 0.1394 | 0.3768 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0 | 0.5 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0138 | 0.056 | 0.1514 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0717 | 0.3699 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0717 | 0.3699 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0717 | 0.3699 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0717 | 0.3699 | 1 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0041 | 0.0034 | 0.0092 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0292 | 0.1394 | 0.3768 |
Treponema pallidum | polypeptide deformylase (def) | 0.1879 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.1879 | 1 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.1879 | 1 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.1879 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.8 ug ml-1 | Antibacterial activity of the compound against Escherichia coli (vogel) | ChEMBL. | 3005575 |
MIC (functional) | = 0.8 ug ml-1 | Antibacterial activity of the compound against Escherichia coli (vogel) | ChEMBL. | 3005575 |
MIC (functional) | = 1.6 ug ml-1 | Antibacterial activity against Klebsiella pneumonia (MGH-2) | ChEMBL. | 3005575 |
MIC (functional) | = 1.6 ug ml-1 | Antibacterial activity against Klebsiella pneumonia (MGH-2) | ChEMBL. | 3005575 |
MIC (functional) | = 25 ug ml-1 | Antibacterial activity of the compound against Escherichia coli (H560) | ChEMBL. | 3005575 |
MIC (functional) | = 25 ug ml-1 | Antibacterial activity of the compound against Escherichia coli (H560) | ChEMBL. | 3005575 |
MIC (functional) | = 50 ug ml-1 | MIC of the compound at which cleaved DNA (linear) is observed at an intensity relative to oxolinic acid at 10 microg/mL by using Gyrase Induced DNA-Cleavage assay | ChEMBL. | 3005575 |
MIC (functional) | = 50 ug ml-1 | MIC of the compound at which cleaved DNA (linear) is observed at an intensity relative to oxolinic acid at 10 microg/mL by using Gyrase Induced DNA-Cleavage assay | ChEMBL. | 3005575 |
MIC (functional) | > 100 ug ml-1 | Antibacterial activity of the compound against Pseudomonas aeruginosa (UI-18) | ChEMBL. | 3005575 |
MIC (functional) | > 100 ug ml-1 | Antibacterial activity of the compound against Staphylococcus aureus (H228) | ChEMBL. | 3005575 |
MIC (functional) | > 100 ug ml-1 | Antibacterial activity of the compound against Streptococcus pneumoniae (SV-1) | ChEMBL. | 3005575 |
MIC (functional) | > 100 ug ml-1 | Antibacterial activity of the compound against Pseudomonas aeruginosa (UI-18) | ChEMBL. | 3005575 |
MIC (functional) | > 100 ug ml-1 | Antibacterial activity of the compound against Staphylococcus aureus (H228) | ChEMBL. | 3005575 |
MIC (functional) | > 100 ug ml-1 | Antibacterial activity of the compound against Streptococcus pneumoniae (SV-1) | ChEMBL. | 3005575 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.