Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | adenosine deaminase | 0.4439 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3378 | 0.4617 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.4439 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.4439 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.4439 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.4439 | 1 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.3378 | 0.4617 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.4439 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.3378 | 0.4617 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3378 | 0.4617 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.4439 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.4439 | 1 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.4439 | 1 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.3378 | 0.4617 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4439 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3378 | 0.4617 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.4439 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3378 | 0.4617 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.4439 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.3378 | 0.4617 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.4439 | 1 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.3378 | 0.4617 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.4439 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.3378 | 0.4617 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.4439 | 1 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.4439 | 1 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.3378 | 0.4617 | 0.5 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.4439 | 1 | 0.5 |
Loa Loa (eye worm) | AMP deaminase | 0.3378 | 0.4617 | 0.4617 |
Entamoeba histolytica | adenosine deaminase, putative | 0.4439 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.4439 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | Concentration required to produce 50% reduction in the rate of proliferation of L1210 cells | ChEMBL. | 3339610 |
IC50 (functional) | > 100 uM | Concentration required to produce 50% reduction in cloning of H.Ep.No.2 cells by 50% | ChEMBL. | 3339610 |
IC50 (functional) | > 100 uM | Concentration required to produce 50% reduction in the rate of proliferation of L1210 cells | ChEMBL. | 3339610 |
IC50 (functional) | > 100 uM | Concentration required to produce 50% reduction in cloning of H.Ep.No.2 cells by 50% | ChEMBL. | 3339610 |
Virus rating (functional) | = 0 | Virus rating on vaccinia virus measured as the degree of inhibition of virus induced cytopathogenic effect in L929 cells | ChEMBL. | 3339610 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.