Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Glutamate receptor ionotropic, AMPA | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0119 | 0.5812 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0119 | 0.5812 | 0.5 |
Onchocerca volvulus | 0.0119 | 0.5812 | 0.5 | |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0106 | 0.4666 | 0.3536 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.5812 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0119 | 0.5812 | 0.4925 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0119 | 0.5812 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.5812 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0119 | 0.5812 | 0.3278 |
Chlamydia trachomatis | glutamine binding protein | 0.0052 | 0 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0052 | 0 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0106 | 0.4666 | 0.1439 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0119 | 0.5812 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0145 | 0.8068 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.5812 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0052 | 0 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0119 | 0.5812 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0167 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.377 | 0.245 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.9 uM | Binding selectivity towards Ionotropic glutamate receptor AMPA was determined by using [3H]- AMPA | ChEMBL. | 12954059 |
Ki (binding) | = 1.9 uM | Binding selectivity towards Ionotropic glutamate receptor AMPA was determined by using [3H]- AMPA | ChEMBL. | 12954059 |
Ki (binding) | = 19 uM | Binding selectivity towards N-methyl-D-aspartate glutamate receptor 1 was determined by using [3H]- glycine/NMDA | ChEMBL. | 12954059 |
Ki (binding) | = 19 uM | Binding selectivity towards N-methyl-D-aspartate glutamate receptor 1 was determined by using [3H]- glycine/NMDA | ChEMBL. | 12954059 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.