Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | AMP deaminase, putative | 0.2019 | 0.4008 | 1 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.2019 | 0.4008 | 0.1519 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.44 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.2019 | 0.4008 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.44 | 1 | 1 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.2019 | 0.4008 | 0.1519 |
Mycobacterium ulcerans | adenosine deaminase | 0.44 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.44 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.44 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.2019 | 0.4008 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.44 | 1 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.44 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2807 | 0.5992 | 0.5992 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2019 | 0.4008 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.2019 | 0.4008 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2019 | 0.4008 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2019 | 0.4008 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.44 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.44 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.44 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.2019 | 0.4008 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2807 | 0.5992 | 0.5992 |
Leishmania major | adenine aminohydrolase | 0.44 | 1 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.2019 | 0.4008 | 0.4008 |
Leishmania major | AMP deaminase, putative | 0.2019 | 0.4008 | 0.1519 |
Loa Loa (eye worm) | hypothetical protein | 0.2807 | 0.5992 | 0.5992 |
Loa Loa (eye worm) | hypothetical protein | 0.1592 | 0.2935 | 0.2935 |
Schistosoma mansoni | adenosine deaminase-related | 0.44 | 1 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.44 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.2019 | 0.4008 | 1 |
Treponema pallidum | adenosine deaminase | 0.44 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.44 | 1 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.44 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.44 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.2019 | 0.4008 | 0.5 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.2019 | 0.4008 | 0.1519 |
Loa Loa (eye worm) | hypothetical protein | 0.2807 | 0.5992 | 0.5992 |
Entamoeba histolytica | adenosine deaminase, putative | 0.44 | 1 | 1 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.2019 | 0.4008 | 0.1519 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2019 | 0.4008 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.44 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4 uM | Inhibitory activity against thrombin (IIa) was determined | ChEMBL. | 12954058 |
IC50 (binding) | = 4 uM | Inhibitory activity against thrombin (IIa) was determined | ChEMBL. | 12954058 |
IC50 (binding) | > 30 uM | Inhibitory activity against tissue coagulation factor VII complex was determined (TF/VIIa complex) | ChEMBL. | 12954058 |
IC50 (binding) | > 30 uM | Inhibitory activity against tissue coagulation factor VII complex was determined (TF/VIIa complex) | ChEMBL. | 12954058 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.