Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Voltage-gated L-type calcium channel alpha-1S subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0084 | 0.0255 | 1 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0093 | 0.0351 | 1 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0093 | 0.0351 | 0.0572 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0062 | 0 | 0.5 |
Schistosoma mansoni | voltage-gated cation channel | 0.0093 | 0.0351 | 0.0572 |
Loa Loa (eye worm) | hypothetical protein | 0.0866 | 0.905 | 0.905 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0 | 0.5 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0927 | 0.9745 | 1 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0093 | 0.0351 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0062 | 0 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0062 | 0 | 0.5 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0093 | 0.0351 | 0.0572 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0093 | 0.0351 | 0.0361 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0062 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0062 | 0 | 0.5 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0093 | 0.0351 | 1 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0062 | 0 | 0.5 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0608 | 0.6146 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.063 | 0.6401 | 0.6401 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0084 | 0.0255 | 1 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0093 | 0.0351 | 1 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0062 | 0 | 0.5 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0093 | 0.0351 | 0.0361 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0093 | 0.0351 | 0.0361 |
Loa Loa (eye worm) | calcium channel | 0.0093 | 0.0351 | 0.0351 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0062 | 0 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0062 | 0 | 0.5 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0093 | 0.0351 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0093 | 0.0351 | 0.0361 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0093 | 0.0351 | 0.0361 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0093 | 0.0351 | 0.0361 |
Onchocerca volvulus | 0.0062 | 0 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0351 | 0.0351 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0062 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0062 | 0 | 0.5 |
Leishmania major | glutaminyl cyclase, putative | 0.0062 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Fold reversion (functional) | = 189 | MDR-reversal property tested in vitro on KB-A1 cells, resistance was induced by adriamycin | ChEMBL. | 8831775 |
Fold reversion (functional) | = 193 | MDR-reversal property tested in vitro on P388/VCR-20 cells, resistance was induced by vincristine | ChEMBL. | 8831775 |
Ki (binding) | = 90 nM | Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscle | ChEMBL. | 8831775 |
Ki (binding) | = 90 nM | Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscle | ChEMBL. | 8831775 |
T/V (functional) | = 1.17 | Ratio of survival time of mice treated with VCR (0.25 mg/kg ip)+modulator given at the optimal dose of 100 mg/kg po/survival time of mice treated with VCR alone. | ChEMBL. | 8831775 |
Viability (functional) | = 102 % | Percent of cell viability of KB-A1 human epidermoid carcinoma remaining after inoculation with the modulator alone | ChEMBL. | 8831775 |
Viability (functional) | = 102 % | Percent of cell viability of KB-A1 human epidermoid carcinoma remaining after inoculation with the modulator alone | ChEMBL. | 8831775 |
Viability (functional) | = 119 % | Percent of cell viability of P388/VCR-20 murine leukemia cells remaining after inoculation with the modulator alone | ChEMBL. | 8831775 |
Viability (functional) | = 119 % | Percent of cell viability of P388/VCR-20 murine leukemia cells remaining after inoculation with the modulator alone | ChEMBL. | 8831775 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.