Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Voltage-gated L-type calcium channel alpha-1S subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.0094 | 0.5605 | 1 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0093 | 0.5535 | 0.5535 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0093 | 0.5535 | 0.5535 |
Leishmania major | 0.0142 | 1 | 0.5 | |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0053 | 0.186 | 0.186 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0142 | 1 | 1 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0053 | 0.186 | 0.186 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0142 | 1 | 1 |
Trypanosoma brucei | beta lactamase | 0.0045 | 0.1152 | 0.1152 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0142 | 1 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0142 | 1 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.5535 | 0.5535 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0053 | 0.186 | 0.186 |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.0094 | 0.5605 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | calcium channel | 0.0093 | 0.5535 | 0.5535 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0142 | 1 | 1 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0053 | 0.186 | 0.186 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0142 | 1 | 1 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0093 | 0.5535 | 0.5535 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0045 | 0.1152 | 0.5 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0093 | 0.5535 | 0.5535 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0053 | 0.186 | 0.186 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Fold reversion (functional) | = 59 | MDR-reversal property tested in vitro on P388/VCR-20 cells, resistance was induced by vincristine | ChEMBL. | 8831775 |
Fold reversion (functional) | = 121 | MDR-reversal property tested in vitro on KB-A1 cells, resistance was induced by adriamycin | ChEMBL. | 8831775 |
Ki (binding) | = 5 nM | Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscle | ChEMBL. | 8831775 |
Ki (binding) | = 5 nM | Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscle | ChEMBL. | 8831775 |
T/V (functional) | = 1.49 | Ratio of survival time of mice treated with VCR (0.25 mg/kg ip)+modulator given at the optimal dose of 100 mg/kg po/survival time of mice treated with VCR alone. | ChEMBL. | 8831775 |
Viability (functional) | = 95 % | Percent of cell viability of P388/VCR-20 murine leukemia cells remaining after inoculation with the modulator alone | ChEMBL. | 8831775 |
Viability (functional) | = 95 % | Percent of cell viability of P388/VCR-20 murine leukemia cells remaining after inoculation with the modulator alone | ChEMBL. | 8831775 |
Viability (functional) | = 120 % | Percent of cell viability of KB-A1 human epidermoid carcinoma remaining after inoculation with the modulator alone | ChEMBL. | 8831775 |
Viability (functional) | = 120 % | Percent of cell viability of KB-A1 human epidermoid carcinoma remaining after inoculation with the modulator alone | ChEMBL. | 8831775 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.