Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Homo sapiens | Coagulation factor VII/tissue factor | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor III (thromboplastin, tissue factor) | References | |
Homo sapiens | coagulation factor VII (serum prothrombin conversion accelerator) | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | glycoprotein Antigen 5 | coagulation factor VII (serum prothrombin conversion accelerator) | 466 aa | 384 aa | 23.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0154 | 0.017 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.0259 | 1 |
Chlamydia trachomatis | phosphoshikimate 1-carboxyl vinyltransferase | 0.0346 | 0.0957 | 1 |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0211 | 0.0405 | 0.5 |
Mycobacterium leprae | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS | 0.0346 | 0.0957 | 0.0873 |
Mycobacterium ulcerans | malate synthase G | 0.2556 | 1 | 1 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0346 | 0.0957 | 0.5 |
Chlamydia trachomatis | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0211 | 0.0405 | 0.3627 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.0346 | 0.0957 | 0.0873 |
Mycobacterium tuberculosis | Malate synthase G GlcB | 0.2556 | 1 | 1 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0211 | 0.0405 | 0.0317 |
Schistosoma mansoni | 3-dehydroquinate synthase | 0.0135 | 0.0092 | 1 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0172 | 0.0242 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0195 | 0.7359 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0211 | 0.0405 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.89 uM | Inhibitory activity against thrombin (IIa) was determined | ChEMBL. | 12954058 |
IC50 (binding) | = 0.89 uM | Inhibitory activity against thrombin (IIa) was determined | ChEMBL. | 12954058 |
IC50 (binding) | = 1 uM | Inhibitory activity against tissue coagulation factor VII complex was determined (TF/VIIa complex) | ChEMBL. | 12954058 |
IC50 (binding) | = 1 uM | Inhibitory activity against tissue coagulation factor VII complex was determined (TF/VIIa complex) | ChEMBL. | 12954058 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.