Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic | References | |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic | Starlite/ChEMBL | References |
Homo sapiens | trace amine associated receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic | References | |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic | References | |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Cation transporter family protein | 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic | 404 aa | 445 aa | 22.0 % |
Brugia malayi | Cation transporter family protein | 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic | 484 aa | 469 aa | 28.6 % |
Echinococcus multilocularis | sex peptide receptor | trace amine associated receptor 1 | 339 aa | 281 aa | 17.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0746 | 0.0522 | 0.0976 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0746 | 0.0522 | 0.0555 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0746 | 0.0522 | 0.0976 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0746 | 0.0522 | 0.088 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0746 | 0.0522 | 0.088 |
Loa Loa (eye worm) | hypothetical protein | 0.0746 | 0.0522 | 0.0555 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0746 | 0.0522 | 0.0976 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0746 | 0.0522 | 0.0555 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0746 | 0.0522 | 0.088 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0746 | 0.0522 | 0.088 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0746 | 0.0522 | 0.088 |
Loa Loa (eye worm) | hypothetical protein | 0.0746 | 0.0522 | 0.0555 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.4394 | 0.5938 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0746 | 0.0522 | 0.0555 |
Schistosoma mansoni | thyroid hormone receptor | 0.0746 | 0.0522 | 0.088 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0746 | 0.0522 | 0.0555 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.6736 | 0.9415 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0746 | 0.0522 | 0.0976 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0746 | 0.0522 | 0.0555 |
Loa Loa (eye worm) | hypothetical protein | 0.0746 | 0.0522 | 0.0555 |
Brugia malayi | nuclear hormone receptor | 0.0746 | 0.0522 | 0.0555 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0746 | 0.0522 | 0.0555 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0746 | 0.0522 | 0.088 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0746 | 0.0522 | 0.0555 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0746 | 0.0522 | 0.088 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.4394 | 0.5938 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0746 | 0.0522 | 0.088 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0746 | 0.0522 | 0.0976 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0746 | 0.0522 | 0.0555 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0746 | 0.0522 | 0.0555 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0746 | 0.0522 | 0.088 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0746 | 0.0522 | 0.088 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0746 | 0.0522 | 0.0555 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.4 | 0.5353 | 1 |
Brugia malayi | nuclear hormone receptor | 0.6736 | 0.9415 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0746 | 0.0522 | 0.0555 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0746 | 0.0522 | 0.088 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0746 | 0.0522 | 0.0555 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0746 | 0.0522 | 0.0555 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0746 | 0.0522 | 0.0555 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0746 | 0.0522 | 0.0555 |
Brugia malayi | ecdysteroid receptor | 0.0746 | 0.0522 | 0.0555 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0746 | 0.0522 | 0.0976 |
Loa Loa (eye worm) | hypothetical protein | 0.0746 | 0.0522 | 0.0555 |
Loa Loa (eye worm) | hypothetical protein | 0.0746 | 0.0522 | 0.0555 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0746 | 0.0522 | 0.0555 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0746 | 0.0522 | 0.0555 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0746 | 0.0522 | 0.088 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0746 | 0.0522 | 0.0555 |
Schistosoma mansoni | thyroid hormone receptor | 0.0746 | 0.0522 | 0.088 |
Loa Loa (eye worm) | hypothetical protein | 0.0746 | 0.0522 | 0.0555 |
Echinococcus granulosus | FTZ F1 alpha | 0.0746 | 0.0522 | 0.088 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0746 | 0.0522 | 0.0976 |
Loa Loa (eye worm) | hypothetical protein | 0.6384 | 0.8893 | 0.9445 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0746 | 0.0522 | 0.0976 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0746 | 0.0522 | 0.0555 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0746 | 0.0522 | 0.0555 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0746 | 0.0522 | 0.0555 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0746 | 0.0522 | 0.0555 |
Brugia malayi | nuclear receptor NHR-88 | 0.0746 | 0.0522 | 0.0555 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0746 | 0.0522 | 0.088 |
Loa Loa (eye worm) | hypothetical protein | 0.0746 | 0.0522 | 0.0555 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0746 | 0.0522 | 0.0555 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0746 | 0.0522 | 0.0555 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0746 | 0.0522 | 0.0976 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0746 | 0.0522 | 0.088 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0746 | 0.0522 | 0.088 |
Schistosoma mansoni | coup transcription factor | 0.0746 | 0.0522 | 0.088 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0746 | 0.0522 | 0.088 |
Loa Loa (eye worm) | hypothetical protein | 0.0746 | 0.0522 | 0.0555 |
Brugia malayi | steroid hormone receptor | 0.0746 | 0.0522 | 0.0555 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0719 | 0.0482 | 0.0812 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 501 nM | Agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal calcium mobilization by calcium 3 assay | ChEMBL. | 18602830 |
Emax (functional) | = 77 % | Agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal calcium mobilization by calcium 3 assay relative to 2-phenylethanamine | ChEMBL. | 18602830 |
Ki (binding) | > 10000 nM | Compound was tested for the inhibition of [3H]-GR-65,630 binding to 5-hydroxytryptamine 3 receptor expressed in NG 108-15 cells | ChEMBL. | 8831767 |
Ki (binding) | > 10000 nM | Compound was tested for the inhibition of [3H]-GR-65,630 binding to 5-hydroxytryptamine 3 receptor expressed in NG 108-15 cells | ChEMBL. | 8831767 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.