Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate NMDA receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.114 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0297 | 0.2397 | 0.023 |
Schistosoma mansoni | hypothetical protein | 0.0297 | 0.2397 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0842 | 0.7315 | 0.655 |
Toxoplasma gondii | peptidase family M13 protein | 0.114 | 1 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0842 | 0.7315 | 0.655 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.114 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0297 | 0.2397 | 0.023 |
Schistosoma mansoni | hypothetical protein | 0.0297 | 0.2397 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0842 | 0.7315 | 0.655 |
Loa Loa (eye worm) | hypothetical protein | 0.0842 | 0.7315 | 0.655 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0575 | 0.4903 | 0.345 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0575 | 0.4903 | 0.345 |
Schistosoma mansoni | hypothetical protein | 0.0297 | 0.2397 | 0.023 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.114 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.114 | 1 | 1 |
Mycobacterium ulcerans | zinc metalloprotease | 0.114 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.114 | 1 | 0.5 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.114 | 1 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.114 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0862 | 0.7494 | 0.678 |
Loa Loa (eye worm) | hypothetical protein | 0.0862 | 0.7494 | 0.678 |
Loa Loa (eye worm) | hypothetical protein | 0.0565 | 0.4809 | 0.3329 |
Loa Loa (eye worm) | hypothetical protein | 0.0862 | 0.7494 | 0.678 |
Loa Loa (eye worm) | hypothetical protein | 0.114 | 1 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0575 | 0.4903 | 0.345 |
Schistosoma mansoni | neprilysin | 0.0297 | 0.2397 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0862 | 0.7494 | 0.678 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0575 | 0.4903 | 0.345 |
Loa Loa (eye worm) | hypothetical protein | 0.0862 | 0.7494 | 0.678 |
Loa Loa (eye worm) | hypothetical protein | 0.0862 | 0.7494 | 0.678 |
Schistosoma mansoni | hypothetical protein | 0.0297 | 0.2397 | 0.023 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0297 | 0.2397 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0842 | 0.7315 | 0.655 |
Onchocerca volvulus | 0.0565 | 0.4809 | 0.5 | |
Mycobacterium leprae | probable zinc metalloprotease | 0.114 | 1 | 0.5 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0575 | 0.4903 | 0.345 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0842 | 0.7315 | 0.655 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 6.9 mg kg-1 | Anticonvulsant activity measured by its ability to protect against audiogenic seizure in DBA/2 mice when dosed intraperitoneally 30 min prior to seizure induction. | ChEMBL. | 9406596 |
ED50 (functional) | = 6.9 mg kg-1 | Anticonvulsant activity measured by its ability to protect against audiogenic seizure in DBA/2 mice when dosed intraperitoneally 30 min prior to seizure induction. | ChEMBL. | 9406596 |
HSAI (binding) | = 11 | Human serum albumin index was measured by retention time of the compound on an HPLC column containing human albumin | ChEMBL. | 9406596 |
HSAI (binding) | = 11 | Human serum albumin index was measured by retention time of the compound on an HPLC column containing human albumin | ChEMBL. | 9406596 |
IC50 (binding) | = 352 nM | Affinity for the glycine binding site on rat N-methyl-D-aspartate glutamate receptor 1, determined by displacement of the glycine site antagonist [3H]L-689,560 from rat cortical membranes | ChEMBL. | 9406596 |
IC50 (binding) | = 352 nM | Affinity for the glycine binding site on rat N-methyl-D-aspartate glutamate receptor 1, determined by displacement of the glycine site antagonist [3H]L-689,560 from rat cortical membranes | ChEMBL. | 9406596 |
logP (ADMET) | = 1.45 | Partition coefficient (logP) | ChEMBL. | 9406596 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.