AUC (ADMET)
|
= 14.41 ug hr ml-1
|
Area under curve of the compound was determined at 0-8 hr in IRC mice after peroral administration
|
ChEMBL.
|
14592510
|
AUC (ADMET)
|
= 14.41 ug hr ml-1
|
Area under curve of the compound was determined at 0-8 hr in IRC mice after peroral administration
|
ChEMBL.
|
14592510
|
Cmax (ADMET)
|
= 4.43 ug ml-1
|
Cmax value of the compound was determined in IRC mice
|
ChEMBL.
|
14592510
|
Cmax (ADMET)
|
= 4.430000000000002 ug ml-1
|
Cmax value of the compound was determined in IRC mice
|
ChEMBL.
|
14592510
|
Cmax (ADMET)
|
= 10.24 uM
|
Cmax value of the compound was determined in IRC mice
|
ChEMBL.
|
14592510
|
Cmax (ADMET)
|
= 10.24 uM
|
Cmax value of the compound was determined in IRC mice
|
ChEMBL.
|
14592510
|
EC50 (functional)
|
= 0.7 nM
|
In vitro agonistic activity against PPAR gamma along with 100 nM BRL49653
|
ChEMBL.
|
14592510
|
EC50 (functional)
|
= 0.7 nM
|
In vitro agonistic activity against PPAR gamma along with 100 nM BRL49653
|
ChEMBL.
|
14592510
|
EC50 (functional)
|
= 92 nM
|
In vitro agonistic activity against RXR alpha in CV-1 cells
|
ChEMBL.
|
14592510
|
EC50 (functional)
|
= 92 nM
|
In vitro agonistic activity against RXR alpha in CV-1 cells
|
ChEMBL.
|
14592510
|
EC50 (functional)
|
= 99 nM
|
In vitro agonist efficacy against PPAR gamma along with 100 nM BRL49653
|
ChEMBL.
|
14592510
|
EC50 (functional)
|
= 99 nM
|
In vitro agonist efficacy against PPAR gamma along with 100 nM BRL49653
|
ChEMBL.
|
14592510
|
Efficacy (functional)
|
= 39 nM
|
In vitro anatagonist efficacy against RXR alpha in CV-1 cells
|
ChEMBL.
|
14592510
|
Efficacy (functional)
|
= 39 nM
|
In vitro anatagonist efficacy against RXR alpha in CV-1 cells
|
ChEMBL.
|
14592510
|
Efficacy (functional)
|
= 44 nM
|
In vitro agonist efficacy against RXR alpha in CV-1 cells
|
ChEMBL.
|
14592510
|
Efficacy (functional)
|
= 44 nM
|
In vitro agonist efficacy against RXR alpha in CV-1 cells
|
ChEMBL.
|
14592510
|
IC50 (functional)
|
= 5.3 nM
|
In vitro anatagonist activity against RXR alpha in CV-1 cells
|
ChEMBL.
|
14592510
|
IC50 (functional)
|
= 5.3 nM
|
In vitro anatagonist activity against RXR alpha in CV-1 cells
|
ChEMBL.
|
14592510
|
Ki (binding)
|
= 6.3 nM
|
Binding affinity against RXR alpha receptor using [3H]-9-cis-RA as radioligand in CV-1 cells
|
ChEMBL.
|
14592510
|
Ki (binding)
|
= 6.3 nM
|
Binding affinity against RXR alpha receptor using [3H]-9-cis-RA as radioligand in CV-1 cells
|
ChEMBL.
|
14592510
|
Ki (binding)
|
= 7.7 nM
|
Binding affinity against RXR gamma receptor using [3H]-9-cis-RA as radioligand in CV-1 cells
|
ChEMBL.
|
14592510
|
Ki (binding)
|
= 7.7 nM
|
Binding affinity against RXR gamma receptor using [3H]-9-cis-RA as radioligand in CV-1 cells
|
ChEMBL.
|
14592510
|
Ki (binding)
|
= 8.5 nM
|
Displacement of [3H]-9-cis-RA from RXR beta receptor in CV-1 cells
|
ChEMBL.
|
14592510
|
Ki (binding)
|
= 8.5 nM
|
Displacement of [3H]-9-cis-RA from RXR beta receptor in CV-1 cells
|
ChEMBL.
|
14592510
|
Ki (binding)
|
> 10000 nM
|
Binding affinity against RAR alpha receptor using [3H]-ATRA as radioligand in CV-1 cells
|
ChEMBL.
|
14592510
|
Ki (binding)
|
> 10000 nM
|
Binding affinity against RAR beta receptor using [3H]-ATRA as radioligand in CV-1 cells
|
ChEMBL.
|
14592510
|
Ki (binding)
|
> 10000 nM
|
Binding affinity against RAR gamma receptor using [3H]-ATRA as radioligand in CV-1 cells
|
ChEMBL.
|
14592510
|
Ki (binding)
|
> 10000 nM
|
Binding affinity against RAR alpha receptor using [3H]-ATRA as radioligand in CV-1 cells
|
ChEMBL.
|
14592510
|
Ki (binding)
|
> 10000 nM
|
Binding affinity against RAR beta receptor using [3H]-ATRA as radioligand in CV-1 cells
|
ChEMBL.
|
14592510
|
Ki (binding)
|
> 10000 nM
|
Binding affinity against RAR gamma receptor using [3H]-ATRA as radioligand in CV-1 cells
|
ChEMBL.
|
14592510
|
Synergy (functional)
|
= 2.8 nM
|
Agonist synergy against RAR alpha was tested along with 3 nM TTNPB
|
ChEMBL.
|
14592510
|
Synergy (functional)
|
= 2.8 nM
|
Agonist synergy against RAR alpha was tested along with 3 nM TTNPB
|
ChEMBL.
|
14592510
|
T max (ADMET)
|
= 1 hr
|
Tmax value of the compound was determined in IRC mice
|
ChEMBL.
|
14592510
|
Tmax (ADMET)
|
= 1 hr
|
Tmax value of the compound was determined in IRC mice
|
ChEMBL.
|
14592510
|