Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nuclear hormone receptor | 0.0041 | 0.0109 | 0.0358 |
Echinococcus granulosus | expressed conserved protein | 0.0092 | 0.0425 | 0.1582 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0026 | 0.0017 | 0.0064 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0184 | 0.0995 | 0.3826 |
Schistosoma mansoni | thyroid hormone receptor | 0.0304 | 0.1738 | 0.6662 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0041 | 0.0109 | 0.0358 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0041 | 0.0109 | 0.0419 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0443 | 0.2601 | 0.2588 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0041 | 0.0109 | 0.0419 |
Leishmania major | chloride channel protein, putative | 0.0026 | 0.0017 | 0.0064 |
Brugia malayi | CHE-14 protein | 0.0042 | 0.0115 | 0.0441 |
Brugia malayi | nuclear receptor NHR-88 | 0.0041 | 0.0109 | 0.0419 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0443 | 0.2601 | 1 |
Leishmania major | CBS domain protein, conserved | 0.0026 | 0.0017 | 0.0064 |
Schistosoma mansoni | thyroid hormone receptor | 0.0304 | 0.1738 | 0.6662 |
Giardia lamblia | Manganese-dependent inorganic pyrophosphatase, putative | 0.0026 | 0.0017 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0076 | 0.1641 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0443 | 0.2601 | 1 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.021 | 0.1158 | 0.4454 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0233 | 0.1296 | 0.4983 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0041 | 0.0109 | 0.0419 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0109 | 0.0419 |
Mycobacterium leprae | conserved hypothetical protein | 0.0026 | 0.0017 | 0.0064 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.0115 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0041 | 0.0109 | 0.0419 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0098 | 0.0462 | 0.1724 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0041 | 0.0109 | 0.1096 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0109 | 0.0419 |
Mycobacterium tuberculosis | Conserved protein | 0.0026 | 0.0017 | 0.0064 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0041 | 0.0109 | 0.0358 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0098 | 0.0462 | 1 |
Mycobacterium ulcerans | cystathionine beta-synthase | 0.0026 | 0.0017 | 0.0064 |
Leishmania major | chloride channel protein, putative | 0.0026 | 0.0017 | 0.0064 |
Mycobacterium leprae | Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) | 0.0026 | 0.0017 | 0.0064 |
Loa Loa (eye worm) | chloride channel 3 | 0.0026 | 0.0017 | 0.0064 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0417 | 0.2437 | 0.9373 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0041 | 0.0109 | 0.1096 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0109 | 0.0419 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0443 | 0.2601 | 1 |
Mycobacterium ulcerans | transcriptional regulator | 0.0026 | 0.0017 | 0.0064 |
Brugia malayi | chloride channel protein 7 | 0.0026 | 0.0017 | 0.0064 |
Giardia lamblia | 5-AMP-activated protein kinase, gamma-1 subunit | 0.0026 | 0.0017 | 0.5 |
Chlamydia trachomatis | CBS domain-containing protein | 0.0026 | 0.0017 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0041 | 0.0109 | 0.0419 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0041 | 0.0109 | 0.0358 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0041 | 0.0109 | 0.0419 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0041 | 0.0109 | 0.0419 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0041 | 0.0109 | 0.0358 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0041 | 0.0109 | 0.0093 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0443 | 0.2601 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0041 | 0.0109 | 0.0419 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0041 | 0.0109 | 0.0419 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0076 | 0.023 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0076 | 0.0059 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0017 | 0.0064 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.014 | 0.0723 | 0.0708 |
Toxoplasma gondii | IMP dehydrogenas | 0.0443 | 0.2601 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0109 | 0.0419 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0105 | 0.0343 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0076 | 0.1641 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0041 | 0.0109 | 0.0358 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0041 | 0.0109 | 0.0419 |
Brugia malayi | CBS domain containing protein | 0.0026 | 0.0017 | 0.0064 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0098 | 0.0462 | 0.0446 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0098 | 0.0462 | 0.1777 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0109 | 0.0419 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0041 | 0.0109 | 0.0093 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0041 | 0.0109 | 0.0358 |
Treponema pallidum | hemolysin (tlyC) | 0.0026 | 0.0017 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0263 | 0.1482 | 0.5673 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0041 | 0.0109 | 0.0419 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0041 | 0.0109 | 0.0093 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0443 | 0.2601 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0042 | 0.0115 | 0.0441 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0233 | 0.1296 | 0.4983 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0417 | 0.2437 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0076 | 0.023 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0042 | 0.0115 | 0.038 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0041 | 0.0109 | 0.0419 |
Loa Loa (eye worm) | loechrig isoform VII | 0.0026 | 0.0017 | 0.0064 |
Trypanosoma cruzi | GMP reductase | 0.0443 | 0.2601 | 1 |
Treponema pallidum | Mg2+ transport protein (mgtE) | 0.0026 | 0.0017 | 0.5 |
Echinococcus multilocularis | protein patched | 0.0042 | 0.0115 | 0.0098 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0041 | 0.0109 | 0.0419 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0026 | 0.0017 | 0.0064 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0076 | 0.1641 |
Trypanosoma cruzi | GMP reductase | 0.0443 | 0.2601 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0041 | 0.0109 | 0.0358 |
Leishmania major | guanosine monophosphate reductase | 0.0443 | 0.2601 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0105 | 0.0343 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0017 | 0.0064 |
Brugia malayi | Voltage gated chloride channel family protein | 0.0026 | 0.0017 | 0.0064 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0443 | 0.2601 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0115 | 0.0441 |
Mycobacterium tuberculosis | Conserved protein | 0.0026 | 0.0017 | 0.0064 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0443 | 0.2601 | 1 |
Echinococcus multilocularis | expressed conserved protein | 0.0092 | 0.0425 | 0.0409 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0041 | 0.0109 | 0.0358 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0017 | 0.0064 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0026 | 0.0017 | 0.0064 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0041 | 0.0109 | 0.0093 |
Mycobacterium tuberculosis | Hypoxic response protein 1 Hrp1 | 0.0026 | 0.0017 | 0.0064 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0041 | 0.0109 | 0.0419 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0041 | 0.0109 | 0.0358 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0041 | 0.0109 | 0.0419 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0259 | 0.146 | 0.5615 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0443 | 0.2601 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0041 | 0.0109 | 0.0419 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.1446 | 0.5559 |
Echinococcus multilocularis | protein dispatched 1 | 0.0048 | 0.0152 | 0.0135 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0041 | 0.0109 | 0.0358 |
Echinococcus granulosus | FTZ F1 alpha | 0.0041 | 0.0109 | 0.0358 |
Giardia lamblia | Hypothetical protein | 0.0026 | 0.0017 | 0.5 |
Onchocerca volvulus | Putative GMP reductase | 0.0184 | 0.0995 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0105 | 0.0343 |
Schistosoma mansoni | patched 1 | 0.0042 | 0.0115 | 0.038 |
Loa Loa (eye worm) | chloride channel protein 7 | 0.0026 | 0.0017 | 0.0064 |
Schistosoma mansoni | hypothetical protein | 0.0263 | 0.1482 | 0.5673 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0041 | 0.0109 | 0.0358 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0041 | 0.0109 | 0.0358 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0259 | 0.146 | 0.5615 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0017 | 0.0064 |
Schistosoma mansoni | coup transcription factor | 0.0041 | 0.0109 | 0.0358 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0041 | 0.0109 | 0.0358 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0041 | 0.0109 | 0.0093 |
Brugia malayi | ecdysteroid receptor | 0.0041 | 0.0109 | 0.0419 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0259 | 0.146 | 0.5615 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0041 | 0.0109 | 0.0419 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0041 | 0.0109 | 0.0358 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.014 | 0.0723 | 0.2735 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0105 | 0.0343 |
Mycobacterium tuberculosis | Probable conserved transmembrane alanine and leucine rich protein | 0.0026 | 0.0017 | 0.0064 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0041 | 0.0109 | 0.0419 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0041 | 0.0109 | 0.0093 |
Brugia malayi | nuclear hormone receptor | 0.0041 | 0.0109 | 0.0419 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0109 | 0.0419 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0041 | 0.0109 | 0.0093 |
Brugia malayi | GMP reductase | 0.0184 | 0.0995 | 0.3826 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0173 | 0.0667 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0184 | 0.0995 | 0.3826 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0041 | 0.0109 | 0.0358 |
Chlamydia trachomatis | Mg++ transporter | 0.0026 | 0.0017 | 0.5 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0042 | 0.0115 | 0.0098 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0017 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0462 | 0.1777 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0109 | 0.0419 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0041 | 0.0109 | 0.0419 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0443 | 0.2601 | 1 |
Mycobacterium tuberculosis | Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) | 0.0026 | 0.0017 | 0.0064 |
Brugia malayi | ancient conserved domain protein 4 | 0.0026 | 0.0017 | 0.0064 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0041 | 0.0109 | 0.0419 |
Onchocerca volvulus | 0.0026 | 0.0017 | 0.0166 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0041 | 0.0109 | 0.0419 |
Brugia malayi | steroid hormone receptor | 0.0041 | 0.0109 | 0.0419 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0042 | 0.0115 | 0.038 |
Onchocerca volvulus | 0.0041 | 0.0109 | 0.1096 | |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0017 | 0.0064 |
Mycobacterium leprae | PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) | 0.021 | 0.1158 | 0.4454 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0017 | 0.0064 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0263 | 0.1482 | 0.1468 |
Mycobacterium tuberculosis | Conserved protein | 0.0026 | 0.0017 | 0.0064 |
Giardia lamblia | Manganese-dependent inorganic pyrophosphatase, putative | 0.0026 | 0.0017 | 0.5 |
Brugia malayi | ancient conserved domain protein 2 | 0.0026 | 0.0017 | 0.0064 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0041 | 0.0109 | 0.0358 |
Trypanosoma brucei | GMP reductase | 0.0443 | 0.2601 | 1 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0443 | 0.2601 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0304 | 0.1738 | 0.1724 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0076 | 0.023 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0443 | 0.2601 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0109 | 0.0419 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0041 | 0.0109 | 0.0093 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0443 | 0.2601 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0076 | 0.1641 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0443 | 0.2601 | 1 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0076 | 0.0292 |
Brugia malayi | loechrig isoform VII | 0.0026 | 0.0017 | 0.0064 |
Brugia malayi | CLC chloride channel protein | 0.0026 | 0.0017 | 0.0064 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0041 | 0.0109 | 0.0419 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0417 | 0.2437 | 1 |
Chlamydia trachomatis | GutQ/KpsF family sugar-phosphate isomerase | 0.0026 | 0.0017 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0041 | 0.0109 | 0.0358 |
Loa Loa (eye worm) | GMP reductase | 0.0184 | 0.0995 | 0.3826 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0041 | 0.0109 | 0.0419 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0041 | 0.0109 | 0.1096 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.01 | 0.0472 | 0.1761 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0017 | 0.0064 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0279 | 0.1581 | 0.6079 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | NA 0 mM | Inhibition of Trypanosoma brucei phosphoglycerate kinase (PGK); inactive at 4 mM | ChEMBL. | 11063610 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.