Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lamin | 0.0027 | 0.0867 | 0.0439 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0867 | 0.0439 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0447 | 0.1341 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0867 | 0.0439 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0447 | 0.1341 |
Onchocerca volvulus | 0.0027 | 0.0867 | 1 | |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0021 | 0.0447 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0157 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0447 | 0.1341 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0157 | 1 | 0.5 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0021 | 0.0447 | 0.1341 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0867 | 0.0517 |
Brugia malayi | SWIRM domain containing protein | 0.0021 | 0.0447 | 0.1341 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0867 | 0.2597 |
Onchocerca volvulus | 0.0027 | 0.0867 | 1 | |
Toxoplasma gondii | cytochrome b | 0.0062 | 0.3337 | 1 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0136 | 0.8553 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0447 | 0.1341 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0021 | 0.0447 | 0.5 |
Echinococcus granulosus | lamin | 0.0027 | 0.0867 | 0.0517 |
Leishmania major | UDP-galactopyranose mutase | 0.0021 | 0.0447 | 0.5 |
Toxoplasma gondii | apocytochrome b, putative | 0.0062 | 0.3337 | 1 |
Brugia malayi | cytochrome b | 0.0062 | 0.3337 | 1 |
Schistosoma mansoni | cytochrome b | 0.0062 | 0.3337 | 0.3025 |
Schistosoma mansoni | cytochrome b | 0.0062 | 0.3337 | 0.3025 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0157 | 1 | 1 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0136 | 0.8553 | 1 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0157 | 1 | 1 |
Plasmodium falciparum | cytochrome b | 0.0062 | 0.3337 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0447 | 0.1341 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0062 | 0.3337 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0832 | 0.2494 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0867 | 0.2597 |
Loa Loa (eye worm) | cytochrome b | 0.0062 | 0.3337 | 1 |
Plasmodium vivax | cytochrome b | 0.0062 | 0.3337 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0867 | 0.0439 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0867 | 0.2597 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0867 | 0.2597 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0867 | 0.2597 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0447 | 0.1341 |
Echinococcus granulosus | cytochrome B | 0.0062 | 0.3337 | 0.3565 |
Schistosoma mansoni | lamin | 0.0027 | 0.0867 | 0.0439 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0867 | 0.0517 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0447 | 0.1341 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0867 | 0.0439 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2 mM | Concentration at which the compound inhibits half of the response of N-methyl-D-aspartic acid (NMDA) | ChEMBL. | 6827527 |
IC50 (functional) | = 3 mM | Concentration at which the compound inhibits half of the response of kainic acid (KA) | ChEMBL. | 6827527 |
Response (functional) | < 36 % | Percentage response to 30 microM of N-methyl-D-aspartic acid (NMDA) at 3 mM of the compound in rat striatum slices. | ChEMBL. | 6827527 |
Response (functional) | < 50 % | Percentage response to 0.1 mM of kainic acid (KA) at 3 mM of the compound in rat striatum slices. | ChEMBL. | 6827527 |
Response (functional) | = 94 % | Percentage response to 0.1 mM of quisqualic acid at 3 mM of the compound in rat striatum slices. | ChEMBL. | 6827527 |
Response (functional) | = 106 % | Percentage response to 0.5 mM of L-Glutamic acid at 3 mM of the compound in rat striatum slices. | ChEMBL. | 6827527 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.