Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) | Chorismate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0007 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0007 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0007 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0007 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0007 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0007 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0007 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0007 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0007 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0007 | 0 | 0.5 |
Toxoplasma gondii | chorismate synthase, putative | 0.0216 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0007 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0007 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0007 | 0 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0007 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0007 | 0 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0007 | 0 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0007 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0007 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0007 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0007 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0007 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0007 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0007 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0007 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) | 0.0106 | 0.4752 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0007 | 0 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0007 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0007 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0007 | 0 | 0.5 |
Mycobacterium ulcerans | chorismate synthase | 0.0216 | 1 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0007 | 0 | 0.5 |
Plasmodium falciparum | chorismate synthase | 0.0216 | 1 | 0.5 |
Mycobacterium leprae | Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). | 0.0106 | 0.4752 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0007 | 0 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0007 | 0 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0007 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0007 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0007 | 0 | 0.5 |
Plasmodium vivax | chorismate synthase | 0.0216 | 1 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0007 | 0 | 0.5 |
Onchocerca volvulus | 0.0007 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0007 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0007 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0007 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0007 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0007 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.8 uM | Inhibitory concentration against Streptococcus pneumoniae chorismate synthase | ChEMBL. | 12565943 |
IC50 (binding) | = 0.8 uM | Inhibitory concentration against Streptococcus pneumoniae chorismate synthase | ChEMBL. | 12565943 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.