Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.0086 | 0.2397 | 0.2105 |
Trypanosoma brucei | polo-like protein kinase | 0.0086 | 0.2397 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0086 | 0.2397 | 0.2105 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0049 | 0.0651 | 0.2717 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0058 | 0.1075 | 0.4483 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0086 | 0.2397 | 0.2105 |
Echinococcus granulosus | CREB binding protein | 0.0046 | 0.0509 | 0.2123 |
Echinococcus multilocularis | ectonucleotide | 0.0049 | 0.0651 | 0.2717 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0058 | 0.1075 | 0.4483 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0049 | 0.0651 | 0.2717 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0086 | 0.2397 | 0.2397 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0125 | 0.4193 | 0.3997 |
Echinococcus granulosus | ectonucleotide | 0.0049 | 0.0651 | 0.2717 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0086 | 0.2397 | 0.2105 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0058 | 0.1075 | 0.1075 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0086 | 0.2397 | 0.2105 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0651 | 0.0335 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0125 | 0.4193 | 0.4193 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0086 | 0.2397 | 0.2105 |
Mycobacterium ulcerans | glutaminase | 0.025 | 1 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0042 | 0.0327 | 0.1364 |
Onchocerca volvulus | 0.0125 | 0.4193 | 1 | |
Echinococcus multilocularis | CREB binding protein | 0.0046 | 0.0509 | 0.2123 |
Trichomonas vaginalis | glutaminase, putative | 0.025 | 1 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0058 | 0.1075 | 0.4483 |
Loa Loa (eye worm) | glutaminase 2 | 0.025 | 1 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0086 | 0.2397 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0058 | 0.1075 | 0.4483 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0058 | 0.1075 | 0.1075 |
Schistosoma mansoni | CREB-binding protein 2 | 0.0046 | 0.0509 | 0.0509 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0042 | 0.0327 | 0.1364 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1075 | 0.0773 |
Loa Loa (eye worm) | glutaminase | 0.025 | 1 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0058 | 0.1075 | 0.1075 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0058 | 0.1075 | 0.4483 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.0046 | 0.0509 | 0.0509 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0058 | 0.1075 | 0.4483 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1075 | 0.0773 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1075 | 0.0773 |
Schistosoma mansoni | kinase | 0.0044 | 0.0423 | 0.0423 |
Giardia lamblia | Kinase, PLK | 0.0086 | 0.2397 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0086 | 0.2397 | 0.2105 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0086 | 0.2397 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0058 | 0.1075 | 0.4483 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | CBP-B | 0.0046 | 0.0509 | 0.0188 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0058 | 0.1075 | 0.1075 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0042 | 0.0327 | 0.1364 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0042 | 0.0327 | 0.0327 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0042 | 0.0327 | 0.0327 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0086 | 0.2397 | 0.4241 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.4193 | 0.4193 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0086 | 0.2397 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0058 | 0.1075 | 0.4483 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0086 | 0.2397 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0086 | 0.2397 | 0.2397 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0058 | 0.1075 | 0.4483 |
Echinococcus granulosus | CREB binding protein | 0.0046 | 0.0509 | 0.2123 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0042 | 0.0327 | 0.0327 |
Schistosoma mansoni | glutaminase | 0.025 | 1 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0058 | 0.1075 | 0.4483 |
Brugia malayi | TAZ zinc finger family protein | 0.0046 | 0.0509 | 0.0509 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0058 | 0.1075 | 0.4483 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0086 | 0.2397 | 0.214 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0042 | 0.0327 | 0.1364 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0086 | 0.2397 | 0.5 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0086 | 0.2397 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0058 | 0.1075 | 0.1075 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0042 | 0.0327 | 0.0327 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 1 ug ml-1 | Antibacterial activity against Methicillin-resistant Staphylococcus epidermidis UC12084 (S. e) | ChEMBL. | 14623000 |
MIC (functional) | = 1 ug ml-1 | Antibacterial activity against Streptococcus pneumoniae UC9912 (S.p) | ChEMBL. | 14623000 |
MIC (functional) | = 2 ug ml-1 | Antibacterial activity against Enterococcus faecalis UC9217 (E. f) | ChEMBL. | 14623000 |
MIC (functional) | = 4 ug ml-1 | Antibacterial activity against Methicillin-suceptible Staphylococcus aureus UC9218 | ChEMBL. | 14623000 |
MIC (functional) | > 64 ug ml-1 | Antibacterial activity against Haemophilus influenzae UC30063 (H. influenzae) | ChEMBL. | 14623000 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.