Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0179 | 0 | 0.5 |
Chlamydia trachomatis | glutamine binding protein | 0.0179 | 0 | 0.5 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.031 | 0.2319 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.031 | 0.2319 | 0.5 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.031 | 0.2319 | 0.1229 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0179 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0493 | 0.5571 | 0.4234 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.031 | 0.2319 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0493 | 0.5571 | 0.4943 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0742 | 1 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0179 | 0 | 0.5 |
Toxoplasma gondii | fructose-bisphospatase II | 0.031 | 0.2319 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0529 | 0.6209 | 0.5064 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0179 | 0 | 0.5 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.031 | 0.2319 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0529 | 0.6209 | 0.5671 |
Leishmania major | 0.031 | 0.2319 | 0.5 | |
Schistosoma mansoni | glutamate receptor NMDA | 0.0599 | 0.7451 | 1 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0179 | 0 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.031 | 0.2319 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 2.1 uM | Cytotoxicity against HT-29 cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 2.1 uM | Cytotoxicity against HT-29 cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 2.4 uM | Cytotoxicity against A-498 cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 2.4 uM | Cytotoxicity against A-498 cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 5.6 uM | Cytotoxicity against MCF-7 cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 5.6 uM | Cytotoxicity against MCF-7 cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 6.5 uM | Cytotoxicity against MCF-7R cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 6.5 uM | Cytotoxicity against MCF-7R cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 13 uM | Cytotoxicity against MCF-7ADR cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 13 uM | Cytotoxicity against MCF-7ADR cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 17 uM | Cytotoxicity against A-549 cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 17 uM | Cytotoxicity against A-549 cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 23 uM | Cytotoxicity against PACA-2 cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 23 uM | Cytotoxicity against PACA-2 cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 43 uM | Cytotoxicity against PC-3 cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
ED50 (functional) | = 43 uM | Cytotoxicity against PC-3 cell line in the purdue cell culture screen was determined | ChEMBL. | 10091695 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.