Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cathepsin l1 | 0.0075 | 0.0709 | 0.0709 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0075 | 0.0709 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0075 | 0.0709 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0075 | 0.0709 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0075 | 0.0709 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0075 | 0.0709 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0075 | 0.0709 | 0.0709 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0075 | 0.0709 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0075 | 0.0709 | 1 |
Onchocerca volvulus | 0.0075 | 0.0709 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0075 | 0.0709 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0075 | 0.0709 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 0.0709 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0075 | 0.0709 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 0.0709 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.284 | 0.284 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0075 | 0.0709 | 1 |
Onchocerca volvulus | 0.0075 | 0.0709 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0075 | 0.0709 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0075 | 0.0709 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0075 | 0.0709 | 1 |
Onchocerca volvulus | 0.0075 | 0.0709 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0075 | 0.0709 | 0.5 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.04 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0075 | 0.0709 | 1 |
Leishmania major | cathepsin L-like protease | 0.0075 | 0.0709 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0075 | 0.0709 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.04 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0075 | 0.0709 | 1 |
Onchocerca volvulus | 0.0075 | 0.0709 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0075 | 0.0709 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0075 | 0.0709 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0075 | 0.0709 | 0.5 |
Loa Loa (eye worm) | ctsf protein | 0.0075 | 0.0709 | 0.0709 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0075 | 0.0709 | 0.5 |
Onchocerca volvulus | Cathepsin F homolog | 0.0075 | 0.0709 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0075 | 0.0709 | 1 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0316 | 0.7605 | 0.7605 |
Loa Loa (eye worm) | cysteine protease | 0.0075 | 0.0709 | 0.0709 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0075 | 0.0709 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0075 | 0.0709 | 1 |
Onchocerca volvulus | 0.0075 | 0.0709 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0075 | 0.0709 | 1 |
Schistosoma mansoni | calcium-activated potassium channel | 0.04 | 1 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0075 | 0.0709 | 0.0709 |
Plasmodium vivax | vivapain-2 | 0.0075 | 0.0709 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0075 | 0.0709 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 0.0709 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0075 | 0.0709 | 1 |
Onchocerca volvulus | 0.0075 | 0.0709 | 1 | |
Onchocerca volvulus | 0.0075 | 0.0709 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0075 | 0.0709 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0075 | 0.0709 | 0.5 |
Plasmodium vivax | vivapain-2 | 0.0075 | 0.0709 | 0.5 |
Toxoplasma gondii | cathepsin CPL | 0.0075 | 0.0709 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0075 | 0.0709 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0075 | 0.0709 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0075 | 0.0709 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 0.0709 | 0.5 |
Onchocerca volvulus | Cathepsin L homolog | 0.0075 | 0.0709 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0075 | 0.0709 | 0.0709 |
Onchocerca volvulus | Cathepsin L homolog | 0.0075 | 0.0709 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 0.0709 | 0.5 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0075 | 0.0709 | 0.0709 |
Brugia malayi | Cathepsin L-like precursor | 0.0075 | 0.0709 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0075 | 0.0709 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0075 | 0.0709 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.3329 | 0.3329 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0075 | 0.0709 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 0.0709 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 0.0709 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0495 | 0.0495 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0075 | 0.0709 | 1 |
Leishmania major | cathepsin L-like protease | 0.0075 | 0.0709 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 0.0709 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0075 | 0.0709 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0075 | 0.0709 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0075 | 0.0709 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 0.0709 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0709 | 0.0709 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0075 | 0.0709 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0075 | 0.0709 | 0.0709 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 0.0709 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0075 | 0.0709 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0075 | 0.0709 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 0.0709 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0075 | 0.0709 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0075 | 0.0709 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0075 | 0.0709 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0075 | 0.0709 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0075 | 0.0709 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0075 | 0.0709 | 0.0709 |
Leishmania major | cathepsin L-like protease | 0.0075 | 0.0709 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.04 | 1 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0075 | 0.0709 | 0.0709 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.94 uM | Inhibition of after-hyperpolarization (AHP) in cultured rat sympathetic neurons | ChEMBL. | 8863802 |
Ratio (functional) | = 1.46 | Equi-effective molar ratio expressed as the ratio of tested compound concentration to that of dequalinium that cause 50% inhibition of the AHP in rat sympathetic neurons | ChEMBL. | 8863802 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.