Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Sus scrofa | ADAM17 | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Schistosoma japonicum | ko:K06059 a disintegrin and metalloproteinase domain 17, putative | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus granulosus | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | disintegrin and metalloproteinase | ADAM17 | 112 aa | 99 aa | 42.4 % |
Trypanosoma congolense | hypothetical protein, conserved | ADAM17 | 112 aa | 100 aa | 29.0 % |
Echinococcus multilocularis | disintegrin and metalloproteinase | ADAM17 | 112 aa | 99 aa | 42.4 % |
Onchocerca volvulus | Putative glutaminase 3 | ADAM17 | 112 aa | 105 aa | 45.7 % |
Plasmodium yoelii | A/G-specific adenine glycosylase, putative | ADAM17 | 112 aa | 109 aa | 24.8 % |
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Onchocerca volvulus | ADAM17 | 112 aa | 98 aa | 41.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.3511 | 1 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0557 | 1 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0152 | 0 | 0.5 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0263 | 0.2747 | 0.0466 |
Echinococcus multilocularis | adam 17 protease | 0.0557 | 1 | 1 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0294 | 0.3511 | 0.147 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0263 | 0.2747 | 1 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0263 | 0.2747 | 0.0466 |
Loa Loa (eye worm) | matrixin family protein | 0.0165 | 0.0337 | 0.0961 |
Onchocerca volvulus | Matrilysin homolog | 0.0152 | 0 | 0.5 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0294 | 0.3511 | 0.147 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1 nM | In vitro binding affinity against porcine TACE | ChEMBL. | 14643313 |
IC50 (binding) | = 1 nM | In vitro binding affinity against porcine TACE | ChEMBL. | 14643313 |
IC50 (functional) | = 1.3 uM | In vitro inhibition of TNF-alpha production was determined by using LPS-stimulated human whole blood assay (WBA) | ChEMBL. | 14643313 |
IC50 (functional) | = 1.3 uM | In vitro inhibition of TNF-alpha production was determined by using LPS-stimulated human whole blood assay (WBA) | ChEMBL. | 14643313 |
Ki (binding) | > 2128 nM | Inhibitory activity against matrix metalloproteinase-9 (MMP-9) | ChEMBL. | 14643313 |
Ki (binding) | > 2128 nM | Inhibitory activity against matrix metalloproteinase-9 (MMP-9) | ChEMBL. | 14643313 |
Ki (binding) | > 3333 nM | Inhibitory activity against matrix metalloproteinase-2 (MMP-2) | ChEMBL. | 14643313 |
Ki (binding) | > 3333 nM | Inhibitory activity against matrix metalloproteinase-2 (MMP-2) | ChEMBL. | 14643313 |
Ki (binding) | > 4949 nM | Inhibitory activity of the compound against matrix metalloproteinase-1(MMP-1) | ChEMBL. | 14643313 |
Ki (binding) | > 4949 nM | Inhibitory activity of the compound against matrix metalloproteinase-1(MMP-1) | ChEMBL. | 14643313 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 14643313 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.