Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0187 | 1 | 1 |
Schistosoma mansoni | integrin alpha | 0.0158 | 0.7358 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0187 | 1 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0141 | 0.5765 | 0.5765 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0158 | 0.7358 | 0.7358 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0187 | 1 | 1 |
Echinococcus granulosus | integrin alpha 3 | 0.0121 | 0.3996 | 0.3996 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.5765 | 0.5765 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.5765 | 0.5765 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0187 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0141 | 0.5765 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0141 | 0.5765 | 0.5765 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0141 | 0.5765 | 0.7835 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.5765 | 0.5765 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0158 | 0.7358 | 0.7358 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0141 | 0.5765 | 0.5765 |
Echinococcus multilocularis | serotonin transporter | 0.0141 | 0.5765 | 0.5765 |
Onchocerca volvulus | 0.0141 | 0.5765 | 0.5765 | |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0901 | 0.0901 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0141 | 0.5765 | 0.5765 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0187 | 1 | 1 |
Echinococcus multilocularis | integrin alpha 3 | 0.0121 | 0.3996 | 0.3996 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0141 | 0.5765 | 0.7835 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.4263 | 0.4263 |
Onchocerca volvulus | Putative nachr subunit | 0.0187 | 1 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0141 | 0.5765 | 0.5765 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 100 mg kg-1 | Tested for analgesic activity using tail flick assay in mice | ChEMBL. | 7381841 |
ED50 (functional) | > 100 mg kg-1 | Tested for analgesic activity using tail pinch assay in mice | ChEMBL. | 7381841 |
ED50 (functional) | > 100 mg kg-1 | Tested for sedation using inclined screen test in mice | ChEMBL. | 7381841 |
ED50 (functional) | > 100 mg kg-1 | Tested for analgesic activity using HCl writhe assay in mice in mice | ChEMBL. | 7381841 |
ED50 (functional) | > 100 mg kg-1 | Tested for narcotic antagonistic property using tail-flick procedure in mice after giving subcutaneous dose of 6.3 mg/kg of morphine sulphate | ChEMBL. | 7381841 |
ED50 (functional) | > 100 mg kg-1 | Tested for analgesic activity using tail flick assay in mice | ChEMBL. | 7381841 |
ED50 (functional) | > 100 mg kg-1 | Tested for analgesic activity using tail pinch assay in mice | ChEMBL. | 7381841 |
ED50 (functional) | > 100 mg kg-1 | Tested for sedation using inclined screen test in mice | ChEMBL. | 7381841 |
ED50 (functional) | > 100 mg kg-1 | Tested for analgesic activity using HCl writhe assay in mice in mice | ChEMBL. | 7381841 |
ED50 (functional) | > 100 mg kg-1 | Tested for narcotic antagonistic property using tail-flick procedure in mice after giving subcutaneous dose of 6.3 mg/kg of morphine sulphate | ChEMBL. | 7381841 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.