Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.0402 | 1 | 1 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0402 | 1 | 1 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0071 | 0.0862 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0062 | 0.0613 | 0.0298 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0076 | 0.0999 | 0.0588 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0402 | 1 | 1 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0095 | 0.1534 | 0.1534 |
Onchocerca volvulus | 0.0055 | 0.0436 | 0.5 | |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.04 | 0.9935 | 0.9933 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0051 | 0.0327 | 0.0002 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0095 | 0.1534 | 0.125 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0081 | 0.115 | 0.0853 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0402 | 1 | 1 |
Trypanosoma brucei | macrophage infectivity potentiator, precursor, putative | 0.0055 | 0.0436 | 0.0436 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0402 | 1 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0055 | 0.0436 | 0.0436 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0402 | 1 | 1 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0095 | 0.1534 | 0.1147 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.3504 | 0.3208 |
Schistosoma mansoni | immunophilin | 0.0402 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0056 | 0.0462 | 0.0142 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0076 | 0.0999 | 0.0999 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0055 | 0.0436 | 0.5 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0402 | 1 | 1 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0095 | 0.1534 | 0.1147 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0076 | 0.0997 | 0.0695 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0095 | 0.1534 | 0.1147 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0045 | 0.0151 | 0.0151 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0347 | 0.8474 | 0.8404 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0095 | 0.1534 | 0.1147 |
Echinococcus granulosus | small conductance calcium activated potassium | 0.04 | 0.9935 | 0.9933 |
Schistosoma mansoni | calcium-activated potassium channel | 0.04 | 0.9935 | 0.9933 |
Trichomonas vaginalis | immunophilin, putative | 0.0402 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0071 | 0.0862 | 0.0555 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.3033 | 0.2715 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0095 | 0.1534 | 0.1147 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0055 | 0.0436 | 0.0115 |
Leishmania major | fk506-binding protein 1-like protein | 0.0402 | 1 | 1 |
Giardia lamblia | GTOR | 0.0095 | 0.1534 | 0.1147 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0071 | 0.0862 | 0.0555 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0095 | 0.1534 | 0.125 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0056 | 0.0462 | 0.0142 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0071 | 0.0862 | 0.0555 |
Trichomonas vaginalis | fk506 binding protein, putative | 0.0055 | 0.0436 | 0.0115 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0402 | 1 | 1 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0402 | 1 | 1 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0095 | 0.1534 | 0.1147 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0402 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0095 | 0.1534 | 0.1147 |
Loa Loa (eye worm) | hypothetical protein | 0.04 | 0.9935 | 0.9933 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0064 | 0.067 | 0.0357 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0095 | 0.1534 | 0.1147 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0055 | 0.0436 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0402 | 1 | 1 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0316 | 0.7626 | 0.7518 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0095 | 0.1534 | 0.1147 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0076 | 0.0999 | 0.0588 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0402 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0057 | 0.0478 | 0.0158 |
Schistosoma mansoni | hypothetical protein | 0.04 | 0.9935 | 0.9933 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0055 | 0.0436 | 0.0115 |
Trypanosoma brucei | FKBP-type peptidylprolyl cis-trans isomerase, putative | 0.0055 | 0.0436 | 0.0436 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0095 | 0.1534 | 0.1147 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0076 | 0.0997 | 0.0695 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0095 | 0.1534 | 0.1534 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0051 | 0.0327 | 0.0002 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0055 | 0.0436 | 0.5 |
Onchocerca volvulus | 0.0055 | 0.0436 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0773 | 0.0351 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0071 | 0.0862 | 0.0555 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 0.8474 | 0.8404 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0402 | 1 | 1 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0055 | 0.0436 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0071 | 0.0862 | 0.0555 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0095 | 0.1534 | 0.1147 |
Schistosoma mansoni | immunophilin | 0.0402 | 1 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0402 | 1 | 1 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0402 | 1 | 1 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0402 | 1 | 1 |
Echinococcus multilocularis | fk506 binding protein | 0.0402 | 1 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0402 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0051 | 0.0327 | 0.0002 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0076 | 0.0997 | 0.0695 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0055 | 0.0436 | 0.0115 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0055 | 0.0436 | 0.0436 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0055 | 0.0436 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0055 | 0.0436 | 0.0115 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0051 | 0.0327 | 0.0002 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0057 | 0.0478 | 0.0158 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0071 | 0.0862 | 0.0555 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0076 | 0.0997 | 0.0695 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0402 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0076 | 0.0997 | 0.0695 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0402 | 1 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0402 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0402 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0095 | 0.1534 | 0.125 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0347 | 0.8474 | 0.8404 |
Schistosoma mansoni | immunophilin | 0.0347 | 0.8474 | 0.8404 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0057 | 0.0478 | 0.0158 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0071 | 0.0862 | 0.0555 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0402 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.9 uM | Inhibition of after-hyperpolarization (AHP) in cultured rat sympathetic neurons | ChEMBL. | 8863802 |
Ratio (functional) | = 2.3 | Equi-effective molar ratio expressed as the ratio of tested compound concentration to that of dequalinium that cause 50% inhibition of the AHP in rat sympathetic neurons | ChEMBL. | 8863802 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.