Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | chitinase I | 0.0074 | 0.2393 | 0.2331 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0156 | 0.7265 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0131 | 0.5802 | 0.5815 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0156 | 0.7265 | 1 |
Echinococcus granulosus | dual specificity | 0.0156 | 0.7265 | 0.7324 |
Brugia malayi | hypothetical protein | 0.02 | 0.9919 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.02 | 0.9919 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0083 | 0.2931 | 0.2052 |
Echinococcus multilocularis | serine:threonine protein kinase NLK | 0.0036 | 0.0081 | 0.0082 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.02 | 0.9919 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.02 | 0.9919 | 0.9918 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.02 | 0.9919 | 1 |
Schistosoma mansoni | hypothetical protein | 0.02 | 0.9919 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.02 | 0.9919 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0156 | 0.7265 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.02 | 0.9919 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0131 | 0.5802 | 0.5849 |
Echinococcus multilocularis | dual specificity | 0.0156 | 0.7265 | 0.7324 |
Echinococcus granulosus | acetylcholinesterase | 0.0131 | 0.5802 | 0.5849 |
Onchocerca volvulus | Putative endochitinase | 0.0083 | 0.2931 | 0.2052 |
Brugia malayi | endochitinase | 0.0074 | 0.2393 | 0.235 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0156 | 0.7265 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0131 | 0.5802 | 0.5849 |
Echinococcus granulosus | Cell division cycle 2 protein kinase | 0.0036 | 0.0081 | 0.0082 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0118 | 0.5016 | 0.5057 |
Entamoeba histolytica | chitinase, putative | 0.0074 | 0.2393 | 0.3293 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0156 | 0.7265 | 1 |
Plasmodium falciparum | conserved protein, unknown function | 0.0118 | 0.5016 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 15 | 0.0036 | 0.0081 | 0.0082 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0036 | 0.0081 | 0.0082 |
Onchocerca volvulus | 0.0118 | 0.5016 | 1 | |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0156 | 0.7265 | 1 |
Echinococcus granulosus | serine:threonine protein kinase NLK | 0.0036 | 0.0081 | 0.0082 |
Brugia malayi | Endochitinase | 0.0083 | 0.2931 | 0.2897 |
Echinococcus granulosus | acetylcholinesterase | 0.0131 | 0.5802 | 0.5849 |
Loa Loa (eye worm) | haspin protein kinase | 0.02 | 0.9919 | 0.9918 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0036 | 0.0081 | 0.0082 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0118 | 0.5016 | 0.5016 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0156 | 0.7265 | 1 |
Mycobacterium tuberculosis | Possible chitinase | 0.0064 | 0.1735 | 0.5 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0156 | 0.7265 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.5016 | 0.4975 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0156 | 0.7265 | 0.7302 |
Schistosoma mansoni | protein kinase | 0.0036 | 0.0081 | 0.0082 |
Entamoeba histolytica | protein kinase, putative | 0.0156 | 0.7265 | 1 |
Echinococcus multilocularis | dual specificity | 0.0156 | 0.7265 | 0.7324 |
Schistosoma mansoni | serine/threonine kinase | 0.0036 | 0.0081 | 0.0082 |
Echinococcus granulosus | dual specificity | 0.0156 | 0.7265 | 0.7324 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0036 | 0.0081 | 0.0111 |
Loa Loa (eye worm) | carboxylesterase | 0.0131 | 0.5802 | 0.5768 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0074 | 0.2393 | 0.2331 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1735 | 0.1668 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0036 | 0.0081 | 0.0082 |
Echinococcus multilocularis | Cell division cycle 2 protein kinase | 0.0036 | 0.0081 | 0.0082 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0036 | 0.0081 | 0.0111 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0131 | 0.5802 | 0.5768 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.5016 | 0.4975 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.5802 | 0.5768 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0156 | 0.7265 | 0.7243 |
Echinococcus granulosus | carboxylesterase 5A | 0.0131 | 0.5802 | 0.5849 |
Schistosoma mansoni | hypothetical protein | 0.0118 | 0.5016 | 0.5057 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0156 | 0.7265 | 1 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0118 | 0.5016 | 0.5057 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0156 | 0.7265 | 1 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0156 | 0.7265 | 1 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0156 | 0.7265 | 1 |
Echinococcus granulosus | dual specificity | 0.0156 | 0.7265 | 0.7324 |
Leishmania major | chitinase | 0.0074 | 0.2393 | 0.3218 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0064 | 0.1735 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0156 | 0.7265 | 0.7324 |
Brugia malayi | GSG2 | 0.02 | 0.9919 | 1 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0064 | 0.1735 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0118 | 0.5016 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0131 | 0.5802 | 0.5849 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.5802 | 0.5768 |
Brugia malayi | Carboxylesterase family protein | 0.0131 | 0.5802 | 0.5815 |
Echinococcus multilocularis | dual specificity | 0.0156 | 0.7265 | 0.7324 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0072 | 0.2273 | 0.221 |
Onchocerca volvulus | Putative endochitinase | 0.0083 | 0.2931 | 0.2052 |
Onchocerca volvulus | 0.0118 | 0.5016 | 1 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0131 | 0.5802 | 0.5849 |
Brugia malayi | endochitinase | 0.0083 | 0.2931 | 0.2897 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.21 uM | Electrophysiological assays in Xenopus oocytes expressing cloned NMDA receptor (NR1A/2C) | ChEMBL. | No reference |
Kb (binding) | = 0.095 uM | Binding affinity towards rat brain NMDA receptor glycine site expressed in Xenopus oocyte | ChEMBL. | 7473565 |
Kb (binding) | = 0.095 uM | Evaluated for antagonistic activity against NMDA receptor glycine sites in rat brain cortical membranes using [3H]-DCKA binding assay | ChEMBL. | No reference |
Kb (binding) | = 0.095 uM | Binding affinity towards rat brain NMDA receptor glycine site expressed in Xenopus oocyte | ChEMBL. | 7473565 |
Kb (binding) | = 0.095 uM | Evaluated for antagonistic activity against NMDA receptor glycine sites in rat brain cortical membranes using [3H]-DCKA binding assay | ChEMBL. | No reference |
Kb (binding) | = 4.11 uM | Binding affinity against rat brain Non N-methyl-D-aspartate glutamate receptor glutamate site expressed in Xenopus oocyte | ChEMBL. | 7473565 |
Kb (binding) | = 4.11 uM | Binding affinity against rat brain Non N-methyl-D-aspartate glutamate receptor glutamate site expressed in Xenopus oocyte | ChEMBL. | 7473565 |
Selectivity (binding) | = 43 | Selectivity for glycine site | ChEMBL. | 7473565 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.