Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 18 (vesicular acetylcholine transporter), member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K08155 MFS transporter, DHA1 family, solute carrier family 18 (vesicular, putative | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Echinococcus granulosus | vesicular acetylcholine transporter | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Echinococcus multilocularis | vesicular acetylcholine transporter | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Schistosoma mansoni | vesicular acetylcholine transporter | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Abnormal catecholamine distribution protein 1 | solute carrier family 18 (vesicular acetylcholine transporter), member 3 | 532 aa | 504 aa | 34.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | c src tyrosine kinase | 0.0013 | 0.0181 | 0.0181 |
Brugia malayi | SRC-1 | 0.0013 | 0.0181 | 0.022 |
Schistosoma mansoni | tyrosine kinase | 0.0013 | 0.0181 | 0.0184 |
Schistosoma mansoni | tyrosine kinase | 0.0013 | 0.0181 | 0.0184 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0012 | 0.0129 | 0.0156 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0013 | 0.0181 | 0.0181 |
Brugia malayi | Variant SH3 domain containing protein | 0.0012 | 0.0129 | 0.0156 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0013 | 0.0181 | 0.0181 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0013 | 0.0181 | 0.0181 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0267 | 0.8243 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0009 | 0.0044 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0317 | 0.9819 | 1 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0267 | 0.8243 | 0.8243 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0013 | 0.0181 | 0.022 |
Brugia malayi | Variant SH3 domain containing protein | 0.0012 | 0.0129 | 0.0156 |
Echinococcus granulosus | NCK adaptor protein | 0.0012 | 0.0129 | 0.0129 |
Brugia malayi | Variant SH3 domain containing protein | 0.0009 | 0.0049 | 0.006 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0013 | 0.0181 | 0.0181 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0013 | 0.0181 | 0.0181 |
Echinococcus multilocularis | arf GAP with SH3 domain, ANK repeat and PH | 0.0009 | 0.0044 | 0.0044 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0013 | 0.0181 | 0.0181 |
Echinococcus granulosus | arf GAP with SH3 domain ANK repeat and PH | 0.0009 | 0.0044 | 0.0044 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0012 | 0.0129 | 0.0131 |
Schistosoma mansoni | vav2 | 0.0009 | 0.0049 | 0.005 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0013 | 0.0181 | 0.0181 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0013 | 0.0181 | 0.0181 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0013 | 0.0181 | 0.0184 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0013 | 0.0181 | 0.0181 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0009 | 0.0049 | 0.006 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0013 | 0.0181 | 0.0181 |
Loa Loa (eye worm) | SRC-1 | 0.0013 | 0.0181 | 0.022 |
Schistosoma mansoni | development and differentiation-enhancing factor ddef | 0.0009 | 0.0044 | 0.0045 |
Echinococcus multilocularis | NCK adaptor protein | 0.0012 | 0.0129 | 0.0129 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0129 | 0.0156 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0012 | 0.0129 | 0.0129 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0013 | 0.0181 | 0.0181 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0267 | 0.8243 | 0.8395 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0013 | 0.0181 | 0.0181 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0013 | 0.0181 | 0.0181 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0012 | 0.0129 | 0.0129 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0322 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0049 | 0.006 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0013 | 0.0181 | 0.0181 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0012 | 0.0129 | 0.0131 |
Schistosoma mansoni | adapter molecule crk | 0.0012 | 0.0129 | 0.0131 |
Schistosoma mansoni | nck2/grb4 | 0.0012 | 0.0129 | 0.0131 |
Schistosoma mansoni | tyrosine kinase | 0.0013 | 0.0181 | 0.0184 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0267 | 0.8243 | 1 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0013 | 0.0181 | 0.0181 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0013 | 0.0181 | 0.0181 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0013 | 0.0181 | 0.0181 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0013 | 0.0181 | 0.0181 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0012 | 0.0129 | 0.0131 |
Schistosoma mansoni | tyrosine kinase | 0.0013 | 0.0181 | 0.0184 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0267 | 0.8243 | 0.8243 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0012 | 0.0129 | 0.0156 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0013 | 0.0181 | 0.0181 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0012 | 0.0129 | 0.0156 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0267 | 0.8243 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 500 nM | Inhibition of active transport of [3H]-Acetylcholine using purified Torpedo californica synaptic vesicles | ChEMBL. | 2724295 |
IC50 (binding) | = 500 nM | Inhibition of active transport of [3H]-Acetylcholine using purified Torpedo californica synaptic vesicles | ChEMBL. | 2724295 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.