Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 18 (vesicular acetylcholine transporter), member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | vesicular acetylcholine transporter | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Schistosoma japonicum | ko:K08155 MFS transporter, DHA1 family, solute carrier family 18 (vesicular, putative | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Echinococcus multilocularis | vesicular acetylcholine transporter | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Echinococcus granulosus | vesicular acetylcholine transporter | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Abnormal catecholamine distribution protein 1 | solute carrier family 18 (vesicular acetylcholine transporter), member 3 | 532 aa | 504 aa | 34.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0429 | 0.0429 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0267 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0429 | 0.0429 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0429 | 0.0429 |
Brugia malayi | PAS domain containing protein | 0.0049 | 0.0557 | 0.0557 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0037 | 0.0001 | 0.0001 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.587 | 0.587 |
Echinococcus granulosus | geminin | 0.0172 | 0.587 | 0.587 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0267 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0429 | 0.0429 |
Mycobacterium ulcerans | putative regulatory protein | 0.0037 | 0.0001 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0429 | 0.0429 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0429 | 0.0429 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0267 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0429 | 0.0429 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0429 | 0.0429 |
Schistosoma mansoni | single-minded | 0.0049 | 0.0557 | 0.0557 |
Brugia malayi | hypoxia-induced factor 1 | 0.0153 | 0.504 | 0.504 |
Echinococcus granulosus | single minded 2 | 0.0037 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.5596 | 0.5398 |
Brugia malayi | bHLH-PAS transcription factor | 0.0037 | 0.0001 | 0.0001 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0267 | 1 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0267 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0172 | 0.587 | 0.587 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0165 | 0.5596 | 0.5596 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0153 | 0.504 | 0.4817 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.587 | 0.587 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0049 | 0.0557 | 0.0557 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2000 nM | Inhibition of active transport of [3H]-Acetylcholine using purified Torpedo californica synaptic vesicles | ChEMBL. | 2724295 |
IC50 (binding) | = 2000 nM | Inhibition of active transport of [3H]-Acetylcholine using purified Torpedo californica synaptic vesicles | ChEMBL. | 2724295 |
LD50 (ADMET) | > 200 uM kg-1 | Lethal dose of the compound, when administered intraperitoneally in mice | ChEMBL. | 2724295 |
LD50 (ADMET) | > 200 uM kg-1 | Lethal dose of the compound, when administered intraperitoneally in mice | ChEMBL. | 2724295 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.