Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | isoleucine--tRNA ligase | 0.013 | 0.1331 | 0.1005 |
Mycobacterium ulcerans | isoleucyl-tRNA synthetase | 0.013 | 0.1331 | 0.2031 |
Mycobacterium ulcerans | formamidopyrimidine-DNA glycosylase | 0.0381 | 0.5134 | 1 |
Trichomonas vaginalis | leucyl-tRNA synthetase, putative | 0.0085 | 0.0655 | 0.4459 |
Trypanosoma cruzi | leucyl-tRNA synthetase, putative | 0.0085 | 0.0655 | 0.4921 |
Entamoeba histolytica | isoleucyl-tRNA synthetase, putative | 0.013 | 0.1331 | 1 |
Plasmodium falciparum | valine--tRNA ligase, putative | 0.0066 | 0.0362 | 0.0151 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0085 | 0.0655 | 0.0304 |
Brugia malayi | isoleucyl-tRNA synthetase | 0.013 | 0.1331 | 1 |
Mycobacterium tuberculosis | Isoleucyl-tRNA synthetase IleS | 0.007 | 0.0425 | 0.0132 |
Trypanosoma brucei | isoleucyl-tRNA synthetase, putative | 0.013 | 0.1331 | 1 |
Plasmodium falciparum | isoleucine--tRNA ligase, putative | 0.044 | 0.604 | 1 |
Echinococcus granulosus | leucyl tRNA synthetase | 0.0085 | 0.0655 | 0.0391 |
Chlamydia trachomatis | isoleucine--tRNA ligase | 0.013 | 0.1331 | 1 |
Trypanosoma cruzi | isoleucyl-tRNA synthetase, putative | 0.013 | 0.1331 | 1 |
Schistosoma mansoni | isoleucine--tRNA ligase | 0.013 | 0.1331 | 0.1005 |
Entamoeba histolytica | leucyl-tRNA synthetase, putative | 0.0085 | 0.0655 | 0.3023 |
Plasmodium vivax | isoleucine--tRNA ligase, putative | 0.013 | 0.1331 | 1 |
Mycobacterium ulcerans | formamidopyrimidine-DNA glycosylase | 0.0381 | 0.5134 | 1 |
Giardia lamblia | Valine-tRNA ligase | 0.0066 | 0.0362 | 0.2059 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0702 | 1 | 1 |
Mycobacterium leprae | Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA GLYCOSYLASE) | 0.0381 | 0.5134 | 1 |
Echinococcus multilocularis | valyl tRNA synthetase | 0.0066 | 0.0362 | 0.009 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0702 | 1 | 1 |
Brugia malayi | leucyl-tRNA synthetase | 0.0085 | 0.0655 | 0.3599 |
Loa Loa (eye worm) | hypothetical protein | 0.0702 | 1 | 1 |
Echinococcus multilocularis | isoleucyl tRNA synthetase, cytoplasmic | 0.013 | 0.1331 | 0.1086 |
Mycobacterium leprae | isoleucyl-tRNA synthetase IleS | 0.013 | 0.1331 | 0.2031 |
Loa Loa (eye worm) | isoleucyl-tRNA synthetase | 0.013 | 0.1331 | 0.1331 |
Wolbachia endosymbiont of Brugia malayi | valyl-tRNA synthetase | 0.0066 | 0.0362 | 0.018 |
Onchocerca volvulus | 0.0094 | 0.0787 | 1 | |
Trichomonas vaginalis | leucyl-tRNA synthetase, putative | 0.0066 | 0.0362 | 0.2059 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0787 | 0.0787 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0085 | 0.0655 | 0.0391 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0702 | 1 | 1 |
Echinococcus granulosus | valyl tRNA synthetase | 0.0066 | 0.0362 | 0.009 |
Trypanosoma brucei | leucyl-tRNA synthetase, putative | 0.0085 | 0.0655 | 0.3023 |
Wolbachia endosymbiont of Brugia malayi | isoleucyl-tRNA synthetase | 0.013 | 0.1331 | 0.2174 |
Brugia malayi | Valyl-tRNA synthetase | 0.0066 | 0.0362 | 0.0827 |
Brugia malayi | isoleucyl-tRNA synthetase family protein | 0.013 | 0.1331 | 1 |
Mycobacterium tuberculosis | Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase) | 0.0381 | 0.5134 | 1 |
Toxoplasma gondii | isoleucyl-tRNA synthetase family protein | 0.013 | 0.1331 | 1 |
Leishmania major | isoleucyl-tRNA synthetase, putative | 0.013 | 0.1331 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.1331 | 0.1331 |
Trypanosoma cruzi | valyl-tRNA synthetase, putative | 0.0066 | 0.0362 | 0.272 |
Toxoplasma gondii | leucyl-tRNA synthetase | 0.0085 | 0.0655 | 0.3599 |
Toxoplasma gondii | valyl-tRNA synthetase | 0.0066 | 0.0362 | 0.0827 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0293 | 0.0293 |
Mycobacterium tuberculosis | Possible DNA glycosylase | 0.0381 | 0.5134 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0111 | 0.0111 |
Loa Loa (eye worm) | hypothetical protein | 0.0702 | 1 | 1 |
Plasmodium falciparum | isoleucine--tRNA ligase, putative | 0.013 | 0.1331 | 0.1832 |
Giardia lamblia | Isoleucyl-tRNA synthetase | 0.013 | 0.1331 | 1 |
Echinococcus granulosus | isoleucyl tRNA synthetase, cytoplasmic | 0.013 | 0.1331 | 0.1086 |
Plasmodium falciparum | leucine--tRNA ligase, putative | 0.0085 | 0.0655 | 0.0659 |
Echinococcus multilocularis | isoleucyl tRNA synthetase, mitochondrial | 0.0094 | 0.0787 | 0.0527 |
Trypanosoma cruzi | leucyl-tRNA synthetase, putative | 0.0049 | 0.0111 | 0.0833 |
Echinococcus multilocularis | valyl tRNA synthetase | 0.0066 | 0.0362 | 0.009 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0702 | 1 | 1 |
Echinococcus granulosus | isoleucyl trna synthetase mitochondrial | 0.0094 | 0.0787 | 0.0527 |
Echinococcus granulosus | valyl tRNA synthetase | 0.0066 | 0.0362 | 0.009 |
Leishmania major | leucyl-tRNA synthetase, putative | 0.0085 | 0.0655 | 0.3023 |
Trichomonas vaginalis | isoleucyl tRNA synthetase, putative | 0.013 | 0.1331 | 1 |
Treponema pallidum | isoleucyl-tRNA synthetase | 0.013 | 0.1331 | 1 |
Wolbachia endosymbiont of Brugia malayi | formamidopyrimidine-DNA glycosylase | 0.0381 | 0.5134 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0085 | 0.0655 | 0.3023 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0275 | 0.0275 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CTS (functional) | = 5.1 | Calcitonin (CT) secretion/RIA assay to measure the ability of compound to increase cellular levels and secretion of human CT. | ChEMBL. | 10737755 |
Rolipram activity (binding) | = 33 % | PDE4 30 assay to measure the percent rolipram activity of the PDE4 assay at 30 micro M concentration of the compound. | ChEMBL. | 10737755 |
Rolipram activity (binding) | = 33 % | PDE4 30 assay to measure the percent rolipram activity of the PDE4 assay at 30 micro M concentration of the compound. | ChEMBL. | 10737755 |
TAR (functional) | = 1.8 | CT-luci reporter gene assay to measure the ability to increase transcription of a luciferase receptor gene linked to the human CT gene. | ChEMBL. | 10737755 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.