Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 18 (vesicular acetylcholine transporter), member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | vesicular acetylcholine transporter unc-17 | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Schistosoma mansoni | vesicular acetylcholine transporter | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Echinococcus granulosus | vesicular acetylcholine transporter | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Echinococcus multilocularis | vesicular acetylcholine transporter | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Schistosoma japonicum | ko:K08155 MFS transporter, DHA1 family, solute carrier family 18 (vesicular, putative | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Abnormal catecholamine distribution protein 1 | solute carrier family 18 (vesicular acetylcholine transporter), member 3 | 532 aa | 504 aa | 34.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0534 | 1 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0445 | 0.7088 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0534 | 1 | 1 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0534 | 1 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0445 | 0.7088 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0445 | 0.7088 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.7088 | 0.7088 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0534 | 1 | 0.5 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0534 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 300 nM | Inhibition of active transport of [3H]-Acetylcholine using purified Torpedo californica synaptic vesicles | ChEMBL. | 2724295 |
IC50 (binding) | = 300 nM | Inhibition of active transport of [3H]-Acetylcholine using purified Torpedo californica synaptic vesicles | ChEMBL. | 2724295 |
LD50 (ADMET) | > 180 uM kg-1 | Lethal dose of the compound, when administered intraperitoneally in mice | ChEMBL. | 2724295 |
LD50 (ADMET) | > 180 uM kg-1 | Lethal dose of the compound, when administered intraperitoneally in mice | ChEMBL. | 2724295 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.