Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Giardia intestinalis | Putative fructose-1,6-bisphosphate aldolase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | fructose-bisphosphate aldolase | Putative fructose-1,6-bisphosphate aldolase | 323 aa | 358 aa | 22.6 % |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | Putative fructose-1,6-bisphosphate aldolase | 323 aa | 361 aa | 26.9 % |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | Putative fructose-1,6-bisphosphate aldolase | 323 aa | 361 aa | 25.5 % |
Candida albicans | fructose-bisphosphate aldolase | Putative fructose-1,6-bisphosphate aldolase | 323 aa | 358 aa | 22.6 % |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | Putative fructose-1,6-bisphosphate aldolase | 323 aa | 361 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.2734 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0353 | 0.2734 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.2734 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.2734 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.0833 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX | 0.0833 | 1 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0353 | 0.2734 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.2734 | 0.5 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0353 | 0.2734 | 1 |
Mycobacterium ulcerans | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.0833 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.2734 | 0.5 |
Chlamydia trachomatis | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.0317 | 0.2183 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.2734 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.2734 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.2734 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0353 | 0.2734 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Broncho selectivity (functional) | = 1 | Ratio of stimulatory activity in right atrium to relaxant activity in tracheal muscle | ChEMBL. | 1331453 |
EC15 (functional) | > 100 uM | Positive chronotropic effect on isolated guinea pig right atrium (heart stimulation). | ChEMBL. | 1331453 |
EC15 (functional) | > 100 uM | Positive chronotropic effect on isolated guinea pig right atrium (heart stimulation). | ChEMBL. | 1331453 |
EC50 (functional) | > 100 uM | Relexant activity on the spontaneous tone of isolated guinea pig tracheal ring chains. | ChEMBL. | 1331453 |
EC50 (functional) | > 100 uM | Relexant activity on the spontaneous tone of isolated guinea pig tracheal ring chains. | ChEMBL. | 1331453 |
Inhibition (binding) | = 24 % | Binding affinity at Adenosine A1 receptor in rat brain cortical membrane using [3H]- N6-R-phenylisopropyladenosine (R-PIA) at 100 uM | ChEMBL. | 8230124 |
Inhibition (binding) | = 24 % | Binding affinity at Adenosine A1 receptor in rat brain cortical membrane using [3H]- N6-R-phenylisopropyladenosine (R-PIA) at 100 uM | ChEMBL. | 8230124 |
Inhibition (ADMET) | = 95.52892741 % | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | ChEMBL. | 23571415 |
Inhibition (ADMET) | = 101.5344276 % | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | ChEMBL. | 23571415 |
K ass (binding) | = 10 M-1 | Binding affinity to DNA intercalator Acridine orange. | ChEMBL. | 11741482 |
Ki (binding) | = 35 uM | Inhibition of 1 nM [3H]- N6-(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat cerebral cortical membranes | ChEMBL. | 2724296 |
Ki (binding) | = 35 uM | Inhibition of 1 nM [3H]- N6-(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat cerebral cortical membranes | ChEMBL. | 2724296 |
Ki (binding) | = 59 uM | Binding affinity against Adenosine A2 receptor in rat striatal membranes using [3H]-5''-N-ethylcarboxamidoadenosine (NECA) as the ligand | ChEMBL. | 8230124 |
Ki (binding) | = 59 uM | Binding affinity against Adenosine A2 receptor in rat striatal membranes using [3H]-5''-N-ethylcarboxamidoadenosine (NECA) as the ligand | ChEMBL. | 8230124 |
Ki (binding) | = 133 uM | Affinity against adenosine A2 receptor in brain membranes by displacement of [3H]-CPX | ChEMBL. | 1331453 |
Ki (binding) | = 133 uM | Affinity against adenosine A2 receptor in brain membranes by displacement of [3H]-CPX | ChEMBL. | 1331453 |
Ki (binding) | = 156 uM | Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscle | ChEMBL. | 1331453 |
Ki (binding) | = 156 uM | Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscle | ChEMBL. | 1331453 |
Ki (binding) | = 240 uM | Inhibition of the stimulation by 5'-(N-ethylcarbamoyl) adenosine of adenyl cyclase via adenosine A2 receptor in human platelet membranes. | ChEMBL. | 2724296 |
Ki (binding) | = 240 uM | Inhibition of the stimulation by 5'-(N-ethylcarbamoyl) adenosine of adenyl cyclase via adenosine A2 receptor in human platelet membranes. | ChEMBL. | 2724296 |
Potency (functional) | = 15.8114 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
5 literature references were collected for this gene.